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Found 104 clinical trials
PROACT: Can we Prevent Chemotherapy-related Heart Damage in Patients With Breast Cancer and Lymphoma?

PROACT will establish the effectiveness of the angiotensin-converting enzyme inhibitor (ACEI) enalapril maleate (enalapril) in preventing cardiotoxicity in patients with breast cancer and non-Hodgkin lymphoma undergoing adjuvant epirubicin-based chemotherapy.

doxorubicin
immunostimulant
hodgkin's disease
epirubicin
her2/neu-positive breast cancer
  • 18 views
  • 24 Jan, 2021
  • 1 location
ACH-TH vs EC-TH as Neoadjuvant Therapy for HER2-positive EBC

Breast cancer is the most common malignant tumor in women. EC-TH is one of the standard chemotherapy regimens for HER-2 positive early breast cancer(EBC). Earlier use of trastuzumab may improve DFS rate. In this study, the investigators want to find out whether ACH-TH regimen compared with the EC-TH regimen in …

doxorubicin
her2/neu-positive breast cancer
cyclophosphamide
erbb2
adjuvant therapy
  • 2 views
  • 23 Jan, 2021
Atezolizumab Combined With Immunogenic Chemotherapy in Patients With Metastatic Triple-negative Breast Cancer

This is a randomized, double-blind, placebo-controlled phase II study evaluating the safety and efficacy of Atezolizumab when combined with immunogenic chemotherapy in subjects with metastatic triple-negative breast cancer. Atezolizumab, pegylated liposomal doxorubicin and cyclophosphamide are the Investigational Medicinal Products (IMPs).

doxorubicin
anthracyclines
epidermal growth factor receptor
epidermal growth factor
growth factor
  • 392 views
  • 07 May, 2021
  • 7 locations
A Trial of Doxil and Multiday Vinorelbine in Patients With Metastatic Breast Cancer

This is a phase II trial of Doxil on day 1 and vinorelbine on days 1 and 2 in women with metastatic breast cancer. Administered every 28 days. A study to assess the safety and efficacy of Doxil and vinorelbine in metastatic breast cancer.

breast cancer
neutrophil count
measurable disease
vinorelbine
advanced breast cancer
  • 13 views
  • 07 Nov, 2020
  • 2 locations
Albumin-bound Paclitaxel and Carboplatin Versus Epirubicin and Docetaxel for Triple-negative Breast Cancer

To investigate the efficacy of albumin-bound paclitaxel combined with carboplatin versus epirubicin combined with docetaxel as neoadjuvant therapy for triple-negative breast cancer.

progesterone receptor
estrogen
erbb2
mammogram
carboplatin
  • 0 views
  • 31 Jul, 2021
  • 7 locations
Improving Exercise Capacity With Tailored Physical Activity in Lymphoma & Breast Cancer Patients Undergoing Tx

To provide critical participant enrollment data necessary to complete a larger definitive clinical trial in the future.

hodgkin's disease
anthracyclines
chemotherapy regimen
aromatase inhibitor
cancer
  • 0 views
  • 27 Jan, 2021
  • 2 locations
Improving the Outcome of High-risk Aggressive B-cell Lymphoma Patients With Nivolumab Maintenance Therapy

This trial is designed as a unicenter, single arm phase II trial. The aim of the trial is to test whether prognosis of high-risk Aggressive B cell Lymphoma (ABCL) patients who are in complete remission (CR) post immunochemotherapy can be improved by 2year nivolumab maintenance therapy. Participants will be recruited …

neutrophil count
blood transfusion
remission
diffuse large b-cell lymphoma
anthracyclines
  • 2 views
  • 23 Jan, 2021
  • 1 location
Adjuvant Chemotherapy for Triple Negative Breast Cancer Patients With Residual Disease After Neoadjuvant Chemotherapy

This study will evaluate the efficacy and safety of antharcycline-based adjuvant chemotherapy compared with observation in triple negative breast cancer (TNBC) patients with residual invasive disease after platinum and taxanes based neoadjuvant chemotherapy.

breast cancer
adenocarcinoma
cyclophosphamide
erbb2
adjuvant chemotherapy
  • 35 views
  • 25 Jan, 2021
  • 1 location
Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses

The present study aims to investigate the chronic effect of treatment with doxorubicin and cyclophosphamide on neurovascular control and blood pressure in women undergoing adjuvant treatment for breast cancer.

adjuvant chemotherapy
cancer
doxorubicin
anthracyclines
cyclophosphamide
  • 0 views
  • 25 Jan, 2021
  • 1 location
Pilot Study of an NTproBNP Guided Strategy of Cardioprotection

Investigators will evaluate the safety and feasibility of a biomarker-guided cardioprotection strategy using NTproBNP, as compared to usual care, in breast cancer and lymphoma patients treated with anthracyclines.

  • 0 views
  • 18 Mar, 2021
  • 1 location