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Found 104 clinical trials
Study for Patients With Newly Diagnosed High-risk Acute Promyelocytic Leukemia

". Despite the dramatic progress achieved in frontline therapy of APL with ATRA plus anthracycline-based regimens, relapses still occur in approximately 20% of patients. Moreover, these regimens

methotrexate
anthracyclines
secondary mds
arsenic
tretinoin
  • 0 views
  • 26 Aug, 2021
  • 8 locations
Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Solid Tumors

This trial will evaluate safety and efficacy of human engineered T-cell therapies, in participants with advanced tumors.

sarcoma
anthracyclines
measurable disease
cyclophosphamide
primary cancer
  • 4 views
  • 15 Jun, 2021
  • 31 locations
Phase III Trial of Anlotinib Catequentinib in Advanced Alveolar Soft Part Sarcoma Leiomyosarcoma Synovial Sarcoma (APROMISS)

This study evaluates the safety and efficacy of AL3818 (anlotinib) hydrochloride in the treatment of metastatic or advanced alveolar soft part sarcoma (ASPS), leiomyosarcoma (LMS), and synovial sarcoma (SS). All participants with ASPS will receive open-label AL3818. In participants with LMS or SS, AL3818 will be compared to IV dacarbazine. …

neutrophil count
anthracyclines
angiogenesis
measurable disease
systemic therapy
  • 323 views
  • 02 Sep, 2021
  • 23 locations
Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

The trial is open to all patients with a diagnosis of acute promyelocytic leukemia (APL) who are PCR-positive for the PML-RAR transcript and less than 18 years of age.

  • 0 views
  • 21 Mar, 2021
  • 29 locations
To Reduce the Use of Chemotherapy in Postmenopausal Patients With ER-positive and HER2-positive Breast Cancer (TOUCH)

This is a phase II open-label, multicentre, randomized trial. The study assesses the treatment of postmenopausal patients with hormone receptor positive/HER2 positive early breast cancer with neoadjuvant palbociclib in combination with hormonal therapy and HER2 blockade, versus the treatment with paclitaxel in combination with HER2 blockade.

estrogen receptor
estradiol
neutrophil count
mammogram
trastuzumab
  • 17 views
  • 17 Sep, 2021
  • 63 locations
Molecular Testing and Imaging in Improving Response in Patients With Stage I-III Triple-Negative Breast Cancer Receiving Chemotherapy MDACC Breast Moonshot Initiative

This clinical trial assesses whether a newly designed algorithm which looks at the genomic signature of each patient's tumor to predict their sensitivity to standard of care treatment verses being placed on a personally designed treatment trial can improve the responses in patients with newly diagnosed triple-negative breast cancer (TNBC). …

immunohistochemistry
neutrophil count
triple-negative breast cancer
absolute neutrophil count
anthracyclines
  • 3 views
  • 31 May, 2021
  • 11 locations
A Treatment Study Protocol for Participants 1-45 Years With Acute Lymphoblastic Leukaemia

ALLTogether collects the experience of previously successful treatment of children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several randomised …

imatinib
dexamethasone
vincristine
inotuzumab
doxorubicin
  • 28 views
  • 27 Jan, 2021
  • 102 locations
Ivabradine to Prevent Anthracycline-induced Cardiotoxicity

heart failure and angina. The aim of this study is to evaluate whether ivabradine might prevent anthracycline-induced cardiotoxicity.

  • 0 views
  • 23 Jan, 2021
  • 1 location
AuTophagy Activation for Cardiomyopathy Due to Anthracycline tReatment (ATACAR)Trial

Researchers are comparing two drug therapy plans to treat heart function changes after anthracycline-based treatment for lymphoma.

  • 0 views
  • 16 May, 2021
  • 1 location
Low-dose CT-based Method for Detection of Subclinical Anthracycline-induced Cardiotoxicity

Prospective single arm study to evaluate a low-dose CT-based protocol for early detection of myocardial dysfunction in 50 cancer patients undergoing anthracycline-based chemotherapy.

bilateral oophorectomy
primary cancer
anthracyclines
  • 1 views
  • 25 Jan, 2021
  • 1 location