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Found 43 clinical trials
Vortioxetine for Post-COVID-19 Condition

A randomized, double-blinded, placebo-controlled trial will be conducted to evaluate vortioxetine, an antidepressant with established pro-cognitive properties, for the treatment of cognitive deficits which develop during or after an infection consistent with COVID-19, continue for 2+ months, and are not explained by an alternative diagnosis (i.e., post-COVID-19 condition). Participants (aged …

  • 24 Jul, 2022
  • 1 location
A Neurosteroid Intervention for Menopausal and Perimenopausal Depression

HYPOTHESIS Pregnenolone administration will be associated with greater reduction in depressive symptom severity than placebo in women with current mMDD. STUDY AIMS: Primary Aim: Determine if pregnenolone is associated with greater reduction in depressive symptom severity than placebo in women with mMDD, as measured by MADRS. Secondary Aims: Determine if …

hot flashes
follicle stimulating hormone
menstrual period
  • 14 Jul, 2022
  • 1 location
The Role of Dopamine in the Central Neural Signature of Chronic Pain

Chronic pain is associated with plasticity in the brain limbic system composed mainly of the amygdala, hippocampus, ventral striatum, and cingulate cortex (ACC) /medial prefrontal cortex (mPFC). These brain areas, especially the ventral striatum, receive dopaminergic input from the ventral-tegmental area (VTA). Although there is a significant literature now showing …

  • 20 Sep, 2022
  • 1 location
Brexpiprazole Treatment for Bipolar I Depression

Bipolar disorder (BD) is a frequent and lifelong recurrent mood disorder with treatment-resistant depressive episodes. Importantly, depressive symptoms and cognitive decline are major determinants of functionality and quality of life in this clinical population. There is robust evidence that individuals with BD have neurocognitive deficits (especially in memory and executive …

Accepts healthy volunteers
mood disorder
psychiatric disorder
adjunctive treatment
depressive symptoms
  • 13 Apr, 2022
  • 1 location
Can Neural Network Instability in Schizophrenia be Improved With a Very Low Carbohydrate Ketogenic Diet?

Cognitive deficits are major drivers of functional decline and poor outcomes in people with schizophrenia (SZ). In the search for interventions targeting underlying cognitive impairment in schizophrenia, we look to the potential role of dysfunctional systemic metabolism. Disrupted insulin and glucose metabolism are seen in medication-naïve first-episode SZ, suggesting that …

  • 20 Aug, 2022
  • 1 location
Increased Emotional-motivational Processing in Patients With Chronic Pain and Its Neural Correlates

Chronic pain causes immense suffering and reductions in quality of life as well as enormous socioeconomic costs. Very many chronic pain patients fall into the category of unspecific pain, i.e. pain without clear medical explanation, with lacking effective treatments. It is assumed that a negative hedonic shift, characterized by excessive …

Accepts healthy volunteers
cancer pain
  • 26 Apr, 2022
  • 1 location
The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease

REM Behavior Sleep Disorder (RBD) is a sleep disorder causing people to 'act out' their dreams. A high percentage of individuals with idiopathic RBD (iRBD) are known to develop conditions affecting the neurons in the brain such as Parkinson's disease (PD). Based on the increased risk to develop PD, individuals …

parkinson's disease
sleep disorder
  • 17 Sep, 2022
  • 1 location
Adjunct Treatment With Cariprazine for Adults With Attention-deficit/Hyperactivity Disorder

According to the Canadian ADHD Practice Guidelines, psychostimulants are the preferred treatment of attention-deficit/hyperactivity disorder (ADHD), especially for those that require urgent care. Specifically, long-acting psychostimulants are considered the gold-standard pharmacological treatment for ADHD. Using extended-release formulations, long-acting psychostimulants provide an extended duration of daily symptom relief in addition to …

  • 19 Dec, 2021
  • 1 location
The Interplay Between Addiction to Tobacco Smoking and Sleep Quality Among Healthy Adults

Tobacco smoking is a major health problem, leading to considerable morbidity and mortality due to cancer, impaired pulmonary function, and cardiovascular diseases. Chronic nicotine consumption related to smoking may affect pulmonary function and can cause neuronal alterations leading to increased emotional distress and decreased cognitive functioning, especially when the smoker …

nicotine dependence
Accepts healthy volunteers
smoke tobacco
tobacco use disorder
  • 26 Feb, 2022
  • 1 location
First choIce Antidepressants: General Practitioner's Treatment Approach in the Czech Republic (FIAT)

practice and MDD management in primary care - aimed to evaluate effectiveness of the treatments in depression and related symptoms: insomnia, anxiety, anhedonia and sexual dysfunction. The primary

  • 10 Apr, 2022