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Found 43 clinical trials
Neural Correlates of Stress and Perceived Control in Adolescent Depression

control as a predictor of "real world" expressions of maladaptive coping and anhedonia.

Accepts healthy volunteers
  • 0 views
  • 05 May, 2022
  • 1 location
Add-on MEmaNtine to Dopamine Antagonism to Improve Negative Symptoms at First Psychosis

, negative symptoms e.g. anhedonia, avolition, and social withdrawal, as well as cognitive deficits, are not sufficiently treated. Memantine is used to treat Alzheimer's disease and affects the

a 12
delusions
schizoaffective disorder
delusional disorder
hallucinations
  • 0 views
  • 05 Sep, 2021
  • 1 location
Effectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIV

, distress tolerance, and anhedonia) was tested against an enhanced standard of care in a pilot randomized controlled trial (NCT01393301). It was found that when compared to a brief enhanced treatment as

nicotine patch
anhedonia
nicotine product
a 10
treatment regimen
  • 92 views
  • 16 Feb, 2021
  • 2 locations
Neural Response to Inflammatory Challenge in Major Depressive Disorder

neurophysiological response to LPS. The main outcome variables are symptoms of anhedonia measured with the Snaith-Hamilton Pleasure Scale (SHAPS), cytokines (Il-6, IL-8, IL-10, and TNF), and BOLD signal change in

Accepts healthy volunteers
  • 0 views
  • 09 Jul, 2022
  • 1 location
EffectsOfTranscranialPulseStimulationOnDepression-PilotRCT

-TPS sessions (300 pulse in each session, total: 1800 pulse) in 2 weeks' time. Outcome measurements include depression, anhedonia, instrumental activities of daily living, cognition and neuroimaging

  • 0 views
  • 22 Aug, 2021
  • 1 location
Dorsomedial Prefrontal Neuromodulation in Treatment-resistant Depression

-state functional MRI (fMRI) demonstrated the abnormal functional connectivity from DMPFC. These abnormalities of networks were highly associated with several depressive symptoms such as anhedonia

  • 0 views
  • 30 Jun, 2022
  • 1 location
Sensitivity, Threshold, Tolerance and Pain Recognition in Schizophrenia Patients and Their Relatives.

hyperactivity in response to a novel environment were reported as correlated with positive symptoms . On the other hand, negative symptoms such as social interaction and anhedonia and cognitive processing (e.g

psychiatric symptoms
Accepts healthy volunteers
antipsychotics
quetiapine
  • 0 views
  • 12 May, 2022
  • 1 location
Inflammation-Induced CNS Glutamate Changes in Depression

Increased inflammation has been implicated in the pathophysiology of a number of neuropsychiatric illnesses including mood disorders, which affect almost 30 million adults in the United States alone. One mechanism by which inflammation may alter behavior is through increasing brain glutamate, a neurotransmitter that in excess has been implicated in …

antidepressants
suicidal
psychotropic drugs
mood disorder
scid
  • 148 views
  • 23 Mar, 2022
  • 1 location
Contraceptive Hormone and Reward Measurement (CHARM Study) (CHARM)

Purpose of this study: The purpose of this study is to learn more about how hormonal oral contraceptives affect brain processes and emotional wellbeing. Procedures: If participants agree to participate, the following will happen: Eligibility visit (remote screening session) If participants are eligible to participate in the study, they will …

Accepts healthy volunteers
  • 0 views
  • 24 Mar, 2022
  • 1 location
Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression

The prevalence of major depressive disorder (MDD) is ~5.0%, and rates of co-occurring SUDs in these patients approach 40-50%. Specifically, rates of co-morbid cannabis use disorder (CUD) in patients with MDD are elevated 2-3 fold compared to 2.9% in the general population, and is associated with poorer treatment outcomes and …

  • 0 views
  • 01 Jul, 2021
  • 1 location