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Found 42 clinical trials
Examining Reward-Related Predictors and Mechanisms of Change in BA Treatment for Anhedonic Adolescents

symptoms in adolescents. Importantly, these reward-circuitry abnormalities have been linked to anhedonia (i.e., decreased pleasure or blunted reactivity to rewarding stimuli). Behavioral Activation (BA

Accepts healthy volunteers
  • 0 views
  • 19 Apr, 2022
  • 1 location
Valuation in Depressed Mood, Anhedonia, and Anxiety

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety

  • 0 views
  • 02 Jun, 2022
  • 1 location
A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy (VENTURA-1)

major depressive disorder (MDD) with moderate-to-severe anhedonia (ANH+) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or

  • 0 views
  • 24 Jul, 2022
  • 3 locations
Depressed Mood and Anhedonia in Healthy Adults (MOOD5)

The aim of this study is to evaluate the effect of nutraceutical supplement on depressed mood and anhedonia in volunteers after 8 weeks of consumption.

Accepts healthy volunteers
  • 0 views
  • 21 Apr, 2022
DTA (Dopaminergic Therapy for Anhedonia) Study

The purpose of this 6-week, double-blind, placebo-controlled, crossover study is to explore new treatment options for people with depression who have high inflammation and anhedonia. Thirty-five

depressed mood
antipsychotics
scid
fluoxetine
anhedonia
  • 0 views
  • 15 Mar, 2022
  • 1 location
  • 0 views
  • 26 Dec, 2021
  • 1 location
Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDD (TERPSIS)

To evaluate the efficacy of NBI-1065846, used as adjunctive treatment to oral antidepressant medication(s), compared with placebo on improving symptoms of anhedonia in subjects with major

  • 0 views
  • 09 Jul, 2022
  • 12 locations
Brain Insulin Resistance in Mood Disorders

The overarching aim of the study is to determine the role of insulin signaling on the neurobiological substrates subserving anhedonia within individuals with mood disorders (i.e., Bipolar

Accepts healthy volunteers
dyslipidemia
body mass index
depressive disorder
  • 0 views
  • 22 Oct, 2021
  • 1 location
Examining the Effects of Estradiol on Neural and Molecular Response to Reward (PEEPS)

This proposal will examine the effects of estradiol administration on perimenopausal-onset (PO) anhedonia and psychosis symptoms as well as on brain function using simultaneous positron emission

  • 0 views
  • 29 Apr, 2022
  • 1 location
The Effects of Wild Blueberries on Depressive Symptoms in Young Adults (BluMood)

This study aims to investigate the effects of a 6-week dietary intervention of 22 g freeze-dried whole wild blueberry powder. The outcomes include measures of depression, anxiety, anhedonia

depressive symptoms
depressed mood
anxiety
anhedonia
  • 0 views
  • 12 May, 2022
  • 1 location