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Found 188 clinical trials
Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes (IPAD)

120 mm Hg, by titration and combination of the study medications of an angiotensin type-1 receptor blocker Allisartan (240 mg/day), a dihydropyridine calcium-channel blocker (amlodipine 5-10 mg/day

antidiabetic drug
antidiabetic agents
angiotensin
antihypertensive drugs
hypertension
  • 28 views
  • 26 Mar, 2022
  • 1 location
Intravenous Amino Acid Therapy for Kidney Protection in Cardiac Surgery. (PROTection)

development by decreasing renal perfusion through a reduction in renal blood flow and through the activation of the sympathetic nervous system and the renin-angiotensin system with afferent arteriolar

continuous infusion
acute renal failure
hypoperfusion
crystalloid solutions
critical illness
  • 1 views
  • 12 Jul, 2022
  • 16 locations
Atrasentan in Patients With IgA Nephropathy (ALIGN)

The ALIGN Study is a phase 3, double-blind, placebo-controlled study to compare the efficacy and safety of atrasentan to placebo in patients with IgA nephropathy (IgAN) at risk of progressive loss of renal function.

renal function
nephropathy
  • 47 views
  • 17 Jun, 2022
  • 119 locations
Phase IV, Double-Blind, Placebo-Controlled, Randomized-Withdrawal Trial Evaluating Sodium Zirconium Cyclosilicate (SZC) for the Management of Hyperkalaemia in Patients With Symptomatic Heart Failure With Reduced Ejection Fraction and Receiving Spironolactone (REALIZE-K)

The main objective of this study is to evaluate the efficacy of SZC as compared with placebo in keeping potassium levels within the normal range (3.5-5.0 mEq/L) while on spironolactone ≥25 mg daily without assistance of rescue therapy for hyperkalaemia (HK).

  • 10 views
  • 21 Sep, 2022
  • 50 locations
A Phase 2b Randomized, Double-blind, Placebo-controlled, Study to Evaluate the Efficacy and Safety of MEDI3506 in Subjects With Diabetic Kidney Disease

A Phase 2b Randomized, Double-blind, Placebo-controlled, Study to Evaluate the Efficacy and Safety of MEDI3506 in Subjects with Diabetic Kidney Disease

diabetic nephropathy
nephropathy
  • 456 views
  • 20 Aug, 2022
  • 75 locations
The GUARDIAN Trial

The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP 85 mmHg, delayed resumption of chronic antihypertensive medications, and a target ward systolic pressure 110 mmHg (tight pressure management); or, 2) routine intraoperative blood pressure management and prompt resumption of chronic antihypertensive medications (routine pressure management).

  • 0 views
  • 28 Aug, 2021
  • 3 locations
Study of the Safety and Efficacy of OMS721 in Patients With Immunoglobulin A (IgA) Nephropathy

The purpose of this study is to evaluate the safety and efficacy of OMS721 in patients with IgA nephropathy. The study will assess proteinuria by 24-hour urine protein excretion (UPE) in g/day at 36 weeks from beginning of treatment.

glomerular filtration rate
immunoglobulin a
nephropathy
immunoglobulins
proteinuria
  • 486 views
  • 05 Mar, 2022
  • 30 locations
S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer

This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it …

trastuzumab
epidermal growth factor receptor
lapatinib
epidermal growth factor
endocrine therapy
  • 286 views
  • 26 Feb, 2022
  • 114 locations
Pentoxifylline in Diabetic Kidney Disease (PTXRx)

Pentoxifylline (PTX) is a medication that has been on the market since 1984 for use in disease in the blood vessels of the legs. There is some preliminary information that it may protect the kidneys from damage due to diabetes and other diseases. "Pentoxifylline in Diabetic Kidney Disease" is a …

diabetic nephropathy
diabetes
pentoxifylline
nephropathy
  • 42 views
  • 20 Jun, 2022
  • 16 locations
Drug-Targeted Alerts for Acute Kidney Injury

In this trial, patients with acute kidney injury who have recently received a drug that may affect kidney function will be randomized to having an alert placed in the electronic health record or usual care.

aldosterone
renal injury
nephropathy
  • 0 views
  • 16 Oct, 2021