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Found 40 clinical trials
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Hereditary Angioedema (HAE)

An open-label study to evaluate the long-term safety of daily oral BCX7353 in subjects with Type I and Type II hereditary angioedema.

angioedema
  • 24 views
  • 14 May, 2020
  • 1 location
featured
HAE - Patients diagnosed with Acute Hereditary Angioedema

HAE - Patients diagnosed with Acute Hereditary Angioedema

  • 598 views
  • 08 Nov, 2020
  • 1 location
CSL312 (Garadacimab) in the Prevention of Hereditary Angioedema Attacks

prophylactic treatment of hereditary angioedema

angioedema
  • 0 views
  • 08 Sep, 2021
  • 29 locations
Long-term Safety and Efficacy of CSL312 (Garadacimab) in the Prophylactic Treatment of Hereditary Angioedema Attacks

This phase 3b study will evaluate long-term safety and efficacy of CSL312 (also known as garadacimab) when administered subcutaneously (SC)

angioedema
  • 0 views
  • 22 Sep, 2021
  • 16 locations
Efficacy and Safety of Lanadelumab (SHP643) in Japanese Participants With Hereditary Angioedema (HAE)

The purpose of this phase 3, open-label, multi-center study is to evaluate the safety and efficacy of lanadelumab in Japanese participants with HAE Type I or II.

c1 inhibitor (human)
bilateral oophorectomy
angioedema
  • 5 views
  • 23 Mar, 2021
  • 12 locations
Expanded Access Program With Lanadelumab for Japanese People With Hereditary Angioedema

angioedema attacks. Lanadelumab is not yet licensed for use in Japan. The main aim of this study is to allow Japanese teenagers and adults with type I or type II hereditary angioedema to be treated

angioedema
bilateral oophorectomy
  • 0 views
  • 22 Sep, 2021
  • 10 locations
Involvement of Monocytic B1 and B2 Receptors in Inflammation and Chronic Vascular Disease in Patients With Hereditary Bradykinetic Angioedema

The objective is to compare the gene expression of B1 and / or B2 monocyte receptors between patients with hereditary bradykinetic angioedema and control subjects.

  • 10 views
  • 23 Jan, 2021
  • 1 location
Lanadelumab in FXII-associated Cold Autoinflammatory Syndrome (FACAS)

This is a Phase 2, exploratory, proof-of-concept, single-center, open-label pilot study to assess the effects and safety of Lanadelumab in patients with FXII-associated cold autoinflammatory syndrome (FACAS).

  • 0 views
  • 26 Jan, 2021
  • 1 location
The Effect of Sitagliptin on Hypertension Arterial Stiffness Oxidative Stress and Inflammation

Recently a new category of antihyperglycemic therapy aiming to modulate the incretin system has emerged. These drugs induce insulin secretion without inducing hypoglycemia. The effect of the incretin modulators drugs on hypertension, arterial stiffness, inflammation and oxidative stress parameters have not been fully investigated yet.GLP-1 analogue has been suggested to …

heart disease
glycosylated hemoglobin
sitagliptin
metformin
hypertension
  • 11 views
  • 07 Nov, 2020
  • 1 location
Dose-ranging Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema

This study evaluates the efficacy of orally administered PHA-022121 for the acute treatment of attacks in patients with hereditary angioedema (HAE). Eligible subjects are randomized to one of

angioedema
  • 0 views
  • 22 Sep, 2021
  • 27 locations