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Found 37 clinical trials
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Hereditary Angioedema (HAE)

An open-label study to evaluate the long-term safety of daily oral BCX7353 in subjects with Type I and Type II hereditary angioedema.

angioedema
  • 22 views
  • 14 May, 2020
  • 1 location
featured
HAE - Patients diagnosed with Acute Hereditary Angioedema

HAE - Patients diagnosed with Acute Hereditary Angioedema

  • 598 views
  • 08 Nov, 2020
  • 1 location
Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema

The objective of this study is to evaluate the safety and tolerability of a single Subcutaneous (SC) dose of Ecallantide in children and adolescents with Hereditary Angioedema (HAE

  • 37 views
  • 07 Nov, 2020
  • 1 location
Efficacy and Safety of Lanadelumab (SHP643) in Japanese Participants With Hereditary Angioedema (HAE)

The purpose of this phase 3, open-label, multi-center study is to evaluate the safety and efficacy of lanadelumab in Japanese participants with HAE Type I or II.

angioedema
  • 5 views
  • 01 Nov, 2020
  • 12 locations
Involvement of Monocytic B1 and B2 Receptors in Inflammation and Chronic Vascular Disease in Patients With Hereditary Bradykinetic Angioedema

The objective is to compare the gene expression of B1 and / or B2 monocyte receptors between patients with hereditary bradykinetic angioedema and control subjects.

  • 10 views
  • 28 Jul, 2019
  • 1 location
Lanadelumab in FXII-associated Cold Autoinflammatory Syndrome (FACAS)

This is a Phase 2, exploratory, proof-of-concept, single-center, open-label pilot study to assess the effects and safety of Lanadelumab in patients with FXII-associated cold autoinflammatory syndrome (FACAS).

  • 0 views
  • 22 Oct, 2020
  • 1 location
Antibiotics to Decrease Post ERCP Cholangitis

Endoscopic retrograde cholangiopancreatography (ERCP) is an endoscopic procedure used to treat bile duct stones, obstructive jaundice, biliary leaks, and a variety of other conditions. There is active debate whether antibiotics should be given prophylactically for ERCP outside of high risk indications including primary sclerosing cholangitis. In part this is due …

  • 10 views
  • 26 May, 2019
  • 1 location
The Effect of Sitagliptin on Hypertension Arterial Stiffness Oxidative Stress and Inflammation

Recently a new category of antihyperglycemic therapy aiming to modulate the incretin system has emerged. These drugs induce insulin secretion without inducing hypoglycemia. The effect of the incretin modulators drugs on hypertension, arterial stiffness, inflammation and oxidative stress parameters have not been fully investigated yet.GLP-1 analogue has been suggested to …

glycosylated hemoglobin
type 2 diabetes mellitus
hypertension
hypoglycemic agents
dipeptidyl peptidase-4 inhibitor
  • 11 views
  • 07 Nov, 2020
  • 1 location
Dupilumab for the Treatment of Chronic Spontaneous Urticaria in Patients Who Remain Symptomatic Despite the Use of H1 Antihistamine and Who Are na ve to Intolerant of or Incomplete Responders to Omalizumab

various timepoints To demonstrate the efficacy of dupilumab on angioedema To demonstrate the efficacy of dupilumab on urticaria control To demonstrate improvement in health-related quality of life and

antihistamines
h1 antihistamine
angioedema
omalizumab
urticaria
  • 10 views
  • 18 Jan, 2021
  • 79 locations
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy

The overall aim of this project is to establish potential benefits of a novel lifestyle (physical activity and dietary nitrate) and pharmacological (angiotensin receptor neprilysin inhibitor) interventions in patients with hypertrophic cardiomyopathy (HCM). HCM is the most common genetic cardiovascular disease with a broad spectrum of disease severity. Angiotensin receptor …

cardiovascular disease
hypertrophic obstructive cardiomyopathy
hypertrophy
vasodilatation
heart failure
  • 0 views
  • 01 Jul, 2020
  • 5 locations