Found 37 clinical trials
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Phase 3 trial
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Accepting Seniors
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Accepting adults
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Immunology
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Currently Recruiting
Hereditary Angioedema (HAE)
An open-label study to evaluate the long-term safety of daily oral BCX7353 in subjects with Type I and Type II hereditary angioedema.
- 22 views
- 14 May, 2020
- 1 location
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Phase 4 trial
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Accepting pediatric ages
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Accepting adults
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Currently Recruiting
HAE - Patients diagnosed with Acute Hereditary Angioedema
HAE - Patients diagnosed with Acute Hereditary Angioedema
- 598 views
- 08 Nov, 2020
- 1 location
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Phase 2 trial
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Accepting pediatric ages
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema
The objective of this study is to evaluate the safety and tolerability of a single Subcutaneous (SC) dose of Ecallantide in children and adolescents with Hereditary Angioedema (HAE
- 37 views
- 07 Nov, 2020
- 1 location
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Phase 3 trial
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Accepting pediatric ages
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Accepting Seniors
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10s of participants
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An interventional trial
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For all genders
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Immunology
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Currently Recruiting
Efficacy and Safety of Lanadelumab (SHP643) in Japanese Participants With Hereditary Angioedema (HAE)
The purpose of this phase 3, open-label, multi-center study is to evaluate the safety and efficacy of lanadelumab in Japanese participants with HAE Type I or II.
- 5 views
- 01 Nov, 2020
- 12 locations
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Unknown Phase
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Involvement of Monocytic B1 and B2 Receptors in Inflammation and Chronic Vascular Disease in Patients With Hereditary Bradykinetic Angioedema
The objective is to compare the gene expression of B1 and / or B2 monocyte receptors between patients with hereditary bradykinetic angioedema and control subjects.
- 10 views
- 28 Jul, 2019
- 1 location
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Phase 2 trial
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Lanadelumab in FXII-associated Cold Autoinflammatory Syndrome (FACAS)
This is a Phase 2, exploratory, proof-of-concept, single-center, open-label pilot study to assess the effects and safety of Lanadelumab in patients with FXII-associated cold autoinflammatory syndrome (FACAS).
- 0 views
- 22 Oct, 2020
- 1 location
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Phase 4 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Antibiotics to Decrease Post ERCP Cholangitis
Endoscopic retrograde cholangiopancreatography (ERCP) is an endoscopic procedure used to treat bile duct stones, obstructive jaundice, biliary leaks, and a variety of other conditions. There is active debate whether antibiotics should be given prophylactically for ERCP outside of high risk indications including primary sclerosing cholangitis. In part this is due …
- 10 views
- 26 May, 2019
- 1 location
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Unknown Phase
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Accepting Seniors
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Accepting adults
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10s of participants
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An interventional trial
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For all genders
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Hematology
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Currently Recruiting
The Effect of Sitagliptin on Hypertension Arterial Stiffness Oxidative Stress and Inflammation
Recently a new category of antihyperglycemic therapy aiming to modulate the incretin system has emerged. These drugs induce insulin secretion without inducing hypoglycemia. The effect of the incretin modulators drugs on hypertension, arterial stiffness, inflammation and oxidative stress parameters have not been fully investigated yet.GLP-1 analogue has been suggested to …
- 11 views
- 07 Nov, 2020
- 1 location
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Multi-country trial
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Phase 3 trial
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Accepting pediatric ages
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Accepting Seniors
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100s of participants
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An interventional trial
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For all genders
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Currently Recruiting
Dupilumab for the Treatment of Chronic Spontaneous Urticaria in Patients Who Remain Symptomatic Despite the Use of H1 Antihistamine and Who Are na ve to Intolerant of or Incomplete Responders to Omalizumab
various timepoints To demonstrate the efficacy of dupilumab on angioedema To demonstrate the efficacy of dupilumab on urticaria control To demonstrate improvement in health-related quality of life and
- 10 views
- 18 Jan, 2021
- 79 locations
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Multi-country trial
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Phase 2 trial
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Accepting Seniors
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Accepting adults
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100s of participants
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An interventional trial
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For all genders
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Cardiology/Vascular Diseases
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Currently Recruiting
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy
The overall aim of this project is to establish potential benefits of a novel lifestyle (physical activity and dietary nitrate) and pharmacological (angiotensin receptor neprilysin inhibitor) interventions in patients with hypertrophic cardiomyopathy (HCM). HCM is the most common genetic cardiovascular disease with a broad spectrum of disease severity. Angiotensin receptor …
- 0 views
- 01 Jul, 2020
- 5 locations