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Found 231 clinical trials
Comparison of Optical Coherence Tomography-derived Minimal Lumen Area, Invasive Fractional Flow Reserve and FFRCT (OPTICO-LM)

angina. Intravascular ultrasound (IVUS)-derived minimum lumen area (MLA) represents an accurate measure to determine LM significance as shown in multiple studies, while optical coherence tomography (OCT

angina pectoris
optical coherence tomography
computed tomography angiography
stable angina
intravascular ultrasound
  • 0 views
  • 09 Feb, 2022
  • 11 locations
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study (EASY-AS)

the AS. Ultimately, compensatory mechanisms fail resulting in angina, syncope or heart failure. If these symptomatic patients with severe AS remain untreated, they have a dire prognosis. In this

tavi
syncope
aortic valve replacement
stenosis
angina pectoris
  • 0 views
  • 28 Feb, 2022
  • 22 locations
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement (COMPLETE TAVR)

composite outcome of Cardiovascular Death, new Myocardial Infarction, Ischemia-driven Revascularization or Hospitalization for Unstable Angina or Heart Failure. The study will be a randomized

  • 0 views
  • 21 Apr, 2022
  • 22 locations
The TransCatheter Valve and Vessels Trial (TCW)

The trial objective is to investigate whether Fractional Flow Reserve (FFR)-Guided Percutaneous Coronary Intervention (PCI) and TransCatheter Aortic Valve Implantation (TAVI) strategy for treatment of multivessel disease and aortic stenosis will be non-inferior to Coronary Artery By-pass Grafting (CABG) and Surgical Aortic Valve Replacement (SAVR) for a composite primary endpoint …

tavi
aortic valve replacement
stenosis
stroke
infarct
  • 54 views
  • 01 Mar, 2022
  • 19 locations
Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes (IPAD)

Lowering of blood pressure (BP) in high-risk hypertensive individuals reduces major adverse cardiovascular and cerebrovascular events. Diabetic patients with hypertension benefit from BP lowering treatment. The present trial, IPAD in brief, is a randomized, open-label, parallel-designed, multicenter study involving nearly 12,000 patients to be recruited and to be followed up …

amlodipine 5 mg
antidiabetic agents
angiotensin
calcium
glycosylated hemoglobin
  • 28 views
  • 26 Mar, 2022
  • 1 location
Randomized Evaluation of Beta Blocker and ACEI/ARB Treatment in MINOCA Patients - MINOCA-BAT (MINOCA-BAT)

Myocardial infarction with non-obstructive coronary arteries" (MINOCA) occurs in 5-10% of all patients with AMI. There are neither any randomized clinical trials in MINOCA patients evaluating effects of secondary preventive treatments proven beneficial in patients with classic AMI, nor any treatment guidelines. The primary objective of this multi-national, multi-center pragmatic …

  • 6 views
  • 04 Feb, 2022
  • 18 locations
Myocardial Ischemia and Transfusion (MINT)

The purpose of this study is to compare two red blood cell transfusion strategies (liberal and restrictive) for patients who have had an acute myocardial infarction and are anemic.

red blood cell transfusion
acute myocardial infarction
ischemia
stemi
infarct
  • 463 views
  • 11 May, 2022
  • 123 locations
The Effect of Antihypertensive Medication Timing on Morbidity and Mortality

High blood pressure is common and its presence increases the risk of cardiovascular mortality and morbidity (most notably stroke, myocardial infarction, and congestive heart failure). Given blood pressure is normally higher during the day than it is overnight, blood pressure lowering medications are traditionally taken in the morning. However a …

antihypertensive drugs
cardiovascular morbidity
stroke
infarct
myocardial infarction
  • 41 views
  • 13 Feb, 2022
  • 2 locations
ISCHEMIA-CTO Trial - Revascularisation or Optimal Medical Therapy of CTO (ISCHEMIA-CTO)

Study design Prospective randomized open labeled multicenter study Hypotheses In asymptomatic patients with ≥ 10% of myocardial ischemia: PCI (Percutaneous Coronary Intervention) with latest generation of drug eluting stents is superior to optimal medical therapy in terms of relative reduction in MACCE (Major Adverse Cardiovascular and Cerebrovascular events). In symptomatic …

heart failure
ischemia
stroke
heart disease
stemi
  • 56 views
  • 22 Mar, 2022
  • 15 locations
Beta-blockers to Patients With Chronic Obstructive Pulmonary Disease

Background: In patients with chronic obstructive pulmonary disease (COPD) and concomitant cardiovascular conditions cardio-selective beta-blockers reduce mortality and can be used without significant negative effects on lung function or respiratory symptoms. Observational studies indicate that beta-blocker therapy in COPD even without overt cardiovascular disease, is associated with reduced risk for …

pulmonary function test
respiratory symptom
spirometry
asthma
copd exacerbation
  • 21 views
  • 18 May, 2022
  • 1 location