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Found 744 clinical trials
Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia

Aplastic anemia is a rare autoimmune disorder in which the bone marrow production of blood cells is greatly decreased or absent. Symptoms include fatigue, weakness, tiny reddish-purple

aplastic anemia
sirolimus
reticulocyte count
platelet count
neutrophil count
  • 100 views
  • 07 Nov, 2020
  • 1 location
Safety and Efficacy Study of Sotatercept in Adults With Transfusion Dependent Diamond Blackfan Anemia

The purpose of this study is to determine the safety and dosing of drug Sotatercept, as a subcutaneous injection, to stimulate production of red blood cell production. To be given every 28 days for up to four doses.

  • 31 views
  • 14 Mar, 2021
  • 1 location
Safety and Efficacy Study of Ex Vivo Immunotherapy for Treatment of Aplastic Anemia

Our hypothesis is that ex vivo activated immune cells would produce multiple known and unknown potent hematopoietic cytokines, working in concert, these cytokines help stem cell growth and differentiation. Additionally, these cells travel and home to bone marrow as well as spleen and liver involved in hematopoietic activities, where direct …

aplastic anemia
immunosuppressive agents
immunosuppression
bone marrow transplant
cytokines
  • 29 views
  • 07 Nov, 2020
  • 1 location
A Monoclonal Antibody Conditioning Regimen for Allogeneic Stem Cell Transplant in Patients With Fanconi Anemia.

Patients eligible for this study have an aggressive blood disease, Fanconi Anemia (FA) that requires an allogeneic (meaning the cells come from a donor) stem cell transplant using a

graft versus host disease
fludarabine
campath
anemia
  • 34 views
  • 07 Nov, 2020
  • 1 location
Desidustat in the Treatment of Anemia in CKD on Dialysis Patients

A phase 3, multicenter, open-label, randomized, active-controlled study to evaluate the efficacy and safety of Desidustat Tablet versus Epoetin alfa Injection for the treatment of anemia in

  • 2 views
  • 03 Feb, 2021
  • 7 locations
Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Background People with severe aplastic anemia (SAA) do not make enough red and white blood cells, and/or platelets. Their body's immune system stops the bone

aplastic anemia
immunosuppression
sirolimus
cyclophosphamide
blood test
  • 7 views
  • 02 Apr, 2021
  • 1 location
Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

Severe aplastic anemia is a rare and serious form of bone marrow failure related to an immune-mediated mechanism that results in severe pancytopenia and high risk for infections and bleeding

aplastic anemia
immunosuppression
cyclophosphamide
fludarabine
rabbit atg
  • 20 views
  • 05 Mar, 2021
  • 2 locations
The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia

Aim: To evaluate if additional cord blood transfusion could accelerate the hematopoietic reconstitution in severe aplastic anemia(SAA) patients receiving immunosuppressive therapy (IST

aplastic anemia
immunosuppression
immunosuppressant
cyclosporine oral product
hla-a
  • 13 views
  • 24 Jan, 2021
  • 1 location
The Oral Iron on the Prevention of Iron Deficiency Anemia in Obese Pregnant

Anemia is known as a condition in which the hemoglobin level is lower than normal. Anemia is one of the most common complications during pregnancy. Anemia in pregnancy is defined as a hemoglobin

  • 0 views
  • 25 Jan, 2021
  • 1 location
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Background Severe aplastic anemia (SAA) is a rare and serious blood disorder. It causes the immune system to turn against bone marrow cells. Standard treatment for

antithymocyte globulin
blood disorder
immunosuppression
aplastic anemia
blood test
  • 1 views
  • 21 Jun, 2021
  • 1 location