Found 109 clinical trials
Effects of Local Dehydroepiandrosterone (DHEA) and Estradiol on Moderate to Severe Dyspareunia, a Symptom of Vulvovaginal Atrophy in Postmenopausal Women - a Randomized, Controlled Study
and after menopause. Furthermore, androgens may have an important function in these symptoms. The purpose of the study is to compare vaginal estrogen with vaginal dehydroepiandrosterone (DHEA, an
- 0 views
- 29 Oct, 2022
- 1 location
A Randomized, Double-blind, Placebo-controlled Phase 2 Study of Darolutamide Versus Placebo in Addition to Standard Androgen Deprivation Therapy for Participants With High-risk Non-metastatic Castration Resistant Prostate Cancer (nmCRPC)
called androgens in the body. The study drug, darolutamide, is already available for doctors to prescribe to patients with prostate cancer that has not yet spread to other parts of the body. It
- 0 views
- 25 Oct, 2022
- 1 location
Aromatase Inhibitors and Weight Loss in Severely Obese Men With Hypogonadism
estradiol by the abundant aromatase enzyme in the adipocytes. The increased conversion of androgens into estrogens in obese men results in a negative feedback of high estradiol levels on hypothalamus and
- 1129 views
- 24 Mar, 2022
- 1 location
Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction (TIN-PCOS-AOD)
phenomenon is independent of excess adiposity and is highly correlated with circulating androgens. In addition, in vitro exposure to proinflammatory stimuli is capable of directly stimulating ovarian theca
- 516 views
- 09 Jun, 2022
- 1 location
Safety and Efficacy of Oral Testosterone Undecanoate Followed by Enzalutamide as Therapy for Men With Metastatic Castrate Resistant Prostate Cancer
Previous studies of high dose testosterone therapy given intramuscularly to men with metastatic castrate resistant prostate cancer suggest that high serum levels of testosterone may be required for clinical response. This injection regimen was given as one dose of 400mg injection every 28 days, which initially produces high serum testosterone …
- 0 views
- 30 May, 2022
- 1 location
Luteinizing Hormone-releasing Hormone Analogue and Enzalutamide +/- Zoledronic Acid in Prostate Cancer Patients (BonEnza)
This study was undertaken to evaluate bone response in metastatic prostate cancer patients treated with Enzalutamide with or without Zoledronic Acid in combination with luteinizing hormone-releasing hormone (LHRH) analogue with the use of Whole Boby (WB) DW-MRI.
- 109 views
- 02 Mar, 2022
- 1 location
Ultrasound Characterization of Ovarian Follicle Dynamics During Weight Loss
The objective of this study is to explore the effects of weight loss on body composition, metabolic status, reproductive hormones, and ovarian follicle development in obese women with regular menstrual cycles versus obese women with irregular menstrual cycles and/or polycystic ovary syndrome (PCOS).
- 284 views
- 16 Oct, 2022
- 1 location
Trial of ARV-110 in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)
Phase 1/2 dose escalation study to assess the safety and tolerability of ARV-110 in men with mCRPC who have progressed on prior approved systemic therapies for their castrate resistant disease (one of which must be enzalutamide or abiraterone).
- 111 views
- 07 Feb, 2022
- 56 locations
Hydraderm for Androgenic Alopecia
The study will be focused on evaluating the use of hydradermabrasion on the scalp. The study aims to assess the effect of this treatment on scalp health and hair growth.
- 0 views
- 08 Jul, 2022
- 1 location
Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy: POWER Trial
The purpose of this research is to determine whether a 16-week culturally tailored, technology-based, aerobic and resistance exercise intervention improves cardiovascular risk factors in Black men diagnosed with prostate cancer and are undergoing androgen deprivation therapy (ADT), and whether it will also improve physical fitness and function, body composition, and …
- 0 views
- 25 Oct, 2022
- 1 location