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Found 11 clinical trials
Cyproterone Acetate in Treating Patients With Newly Diagnosed Stage III or Stage IV Prostate Cancer

RATIONALE: Androgens can cause the growth of prostate cancer cells. Hormone therapy, such as cyproterone acetate may stop the adrenal glands from making androgens. Sometimes the tumor may not need treatment until it progresses. In this case, observation may be sufficient. It is not yet known whether giving cyproterone acetate …

hormone therapy
gonadorelin
endocrine therapy
epinephrine
tumor progression
  • 3 views
  • 07 Nov, 2020
  • 1 location
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer

This is a double-blinded, placebo-controlled randomized phase II clinical trial investigating whether flibanserin promotes sexual interest in men with prostate cancer who are receiving androgen

  • 0 views
  • 04 Aug, 2021
  • 1 location
Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer

with prostate cancer who have localized disease. The benefit of the combination with androgen suppression is not completely understood. This study will compare the use of hypofraction proton therapy

adenocarcinoma
biopsy of prostate
adenocarcinoma of prostate
androgen suppression
androgens
  • 85 views
  • 22 Jan, 2021
  • 5 locations
Assessing Induction of Double Strand Breaks With Androgen Receptor Partial Agonist in Patients on Androgen Suppression

central androgen suppression and brachytherapy.

flutamide
androgen suppression
androgens
brachytherapy
  • 0 views
  • 12 Sep, 2021
  • 1 location
A Multi-Center Trial of Androgen Suppression With Abiraterone Acetate Leuprolide PARP Inhibition and Stereotactic Body Radiotherapy in Prostate Cancer

The purpose of this study is to establish the maximum tolerable dose of niraparib when combined with prostate stereotactic body radiotherapy (SBRT), abiraterone, leuprolide, and prednisone (the phase 1 portion of the study) and determine 3-year biochemical PSA recurrence free-survival with this treatment approach (the phase 2 portion of the …

prednisone
adenocarcinoma
leuprolide
adenocarcinoma of prostate
androgen suppression
  • 0 views
  • 08 Jul, 2021
  • 3 locations
Optimizing Prostate Cancer Treatment in Men With Advanced Local Disease

not compromising the unprecedented high cure rates obtained for the brachytherapy arm of the Androgen Suppression Combined with Elective Nodal and Dose Escalated Radiation Therapy (ASCENDE-RT

pet/ct scan
ct scan
androgen suppression
androgens
external beam radiation therapy
  • 18 views
  • 24 Jan, 2021
  • 1 location
Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

treatment combination of the drugs abiraterone acetate and prednisone (AAP) given with androgen deprivation therapy (ADT, also known as androgen deprivation therapy or androgen suppression medication, which

  • 0 views
  • 15 Aug, 2021
  • 1 location
Randomized Phase II Trial of Salvage Radiotherapy for Prostate Cancer In 4 Weeks v. 2 Weeks

The purpose of this study is to compare urinary and bowel side effects of hypofractionated radiotherapy in 20 treatments (4 weeks) to ultra-hypofractionated radiotherapy in 5 treatments (2 weeks) for prostate cancer that has returned after prostatectomy. The investigators are also interested in looking at time to progression and the …

prostatectomy
bone scan
hypofractionated radiation therapy
metastasis
  • 0 views
  • 11 Jul, 2021
Postop Hypofractionated Radiation Therapy and LHRH in Patients With Prostate Cancer

Prostate cancer is the second most common cancer among Canadian men of which approximately 20-30% present with high-risk tumour characteristic. Although surgery can be curative in patients evidencing pathological high-risk disease (extracapsular extension, seminal vesicle involvement, positive surgical margins), a large proportion will develop biochemical failure within years from the …

adenocarcinoma
adenocarcinoma of prostate
bone metastases
prostate specific antigen
gonadotropin
  • 3 views
  • 15 Sep, 2021
  • 2 locations
Targeted Radiotherapy in Androgen-suppressed Prostate Cancer Patients.

This multi-center, phase II trial will be conducted in men with castration resistant prostate cancer. The aim of the TRAP trial is to test whether a new precise radiotherapy technique called stereotactic body radiotherapy (SBRT) can slow down the growth of metastatic prostate cancer. If SBRT is effective it will …

metastatic prostate cancer
hormone therapy
epinephrine
castration-resistant prostate cancer
androgen suppression
  • 30 views
  • 23 Jan, 2021
  • 6 locations