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Found 10 clinical trials
Flibanserin in Men Receiving Androgen Suppression for Prostate Cancer

This is a double-blinded, placebo-controlled randomized phase II clinical trial investigating whether flibanserin promotes sexual interest in men with prostate cancer who are receiving androgen

  • 0 views
  • 04 Aug, 2021
  • 1 location
Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer

with prostate cancer who have localized disease. The benefit of the combination with androgen suppression is not completely understood. This study will compare the use of hypofraction proton therapy

adenocarcinoma
adenocarcinoma of prostate
biopsy of prostate
brachytherapy
androgens
  • 85 views
  • 10 Nov, 2021
  • 5 locations
Assessing Induction of Double Strand Breaks With Androgen Receptor Partial Agonist in Patients on Androgen Suppression

central androgen suppression and brachytherapy.

brachytherapy
flutamide
androgens
androgen suppression
  • 0 views
  • 06 Feb, 2022
  • 1 location
A Multi-Center Trial of Androgen Suppression With Abiraterone Acetate, Leuprolide, PARP Inhibition and Stereotactic Body Radiotherapy in Prostate Cancer

The purpose of this study is to establish the maximum tolerable dose of niraparib when combined with prostate stereotactic body radiotherapy (SBRT), abiraterone, leuprolide, and prednisone (the phase 1 portion of the study) and determine 3-year biochemical PSA recurrence free-survival with this treatment approach (the phase 2 portion of the …

adenocarcinoma
adenocarcinoma of prostate
abiraterone
prednisone
androgens
  • 0 views
  • 15 Dec, 2021
  • 4 locations
Optimizing Prostate Cancer Treatment in Men With Advanced Local Disease (OPTiMAL)

not compromising the unprecedented high cure rates obtained for the brachytherapy arm of the Androgen Suppression Combined with Elective Nodal and Dose Escalated Radiation Therapy (ASCENDE-RT

external beam radiation therapy
pet/ct scan
ct scan
transrectal ultrasound
rectal ultrasound
  • 18 views
  • 12 Feb, 2022
  • 1 location
Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

treatment combination of the drugs abiraterone acetate and prednisone (AAP) given with androgen deprivation therapy (ADT, also known as androgen deprivation therapy or androgen suppression medication, which

  • 0 views
  • 15 Aug, 2021
  • 1 location
Niraparib With Standard Combination Radiation Therapy and Androgen Deprivation Therapy in Treating Patients With High Risk Prostate Cancer (NADIR)

This phase II trial studies the side effects and best dose of niraparib, and to see how well it works in combination with standard of care radiation therapy and hormonal therapy (androgen deprivation therapy) in treating patients with prostate cancer that has a high chance of coming back (high risk). …

ct scan
MRI
bone scan
gilbert's syndrome
androgens
  • 154 views
  • 26 Apr, 2022
  • 48 locations
Randomized Phase II Trial of Salvage Radiotherapy for Prostate Cancer In 4 Weeks v. 2 Weeks

The purpose of this study is to compare urinary and bowel side effects of hypofractionated radiotherapy in 20 treatments (4 weeks) to ultra-hypofractionated radiotherapy in 5 treatments (2 weeks) for prostate cancer that has returned after prostatectomy. The investigators are also interested in looking at time to progression and the …

hypofractionated radiation therapy
bone scan
metastasis
prostatectomy
  • 0 views
  • 11 Jul, 2021
Postop Hypofractionated Radiation Therapy and LHRH in Patients With Prostate Cancer (PROMPT)

Prostate cancer is the second most common cancer among Canadian men of which approximately 20-30% present with high-risk tumour characteristic. Although surgery can be curative in patients evidencing pathological high-risk disease (extracapsular extension, seminal vesicle involvement, positive surgical margins), a large proportion will develop biochemical failure within years from the …

digital rectal exam
ct scan
testosterone
gonadotropin
prostate specific antigen
  • 3 views
  • 25 Feb, 2022
  • 2 locations
MRI/Ultrasound Fusion Guided Laser Ablation of Prostate Cancer (MRFLA)

This serves as a registration trial. It aims to record short, intermediate, and long-term outcomes of patients treated with targeted laser ablation of biopsy confirmed prostate cancer. Outcomes will be categorized as: 1- Procedure Related, 2- Perioperative - Adverse Events that may occur within 90 days, 3-Oncologic: Recurrence of cancer …

  • 0 views
  • 25 Mar, 2022
  • 1 location