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Found 10 clinical trials
Cyproterone Acetate in Treating Patients With Newly Diagnosed Stage III or Stage IV Prostate Cancer

RATIONALE: Androgens can cause the growth of prostate cancer cells. Hormone therapy, such as cyproterone acetate may stop the adrenal glands from making androgens. Sometimes the tumor may not need treatment until it progresses. In this case, observation may be sufficient. It is not yet known whether giving cyproterone acetate …

hormone therapy
tumor progression
androgens
gonadotropin
endocrine therapy
  • 3 views
  • 07 Nov, 2020
  • 1 location
Hypo-fractionated Radiation Therapy With or Without Androgen Suppression for Intermediate Risk Prostate Cancer

with prostate cancer who have localized disease. The benefit of the combination with androgen suppression is not completely understood. This study will compare the use of hypofraction proton therapy

adenocarcinoma
androgen suppression
androgens
brachytherapy
adenocarcinoma of prostate
  • 85 views
  • 22 Jan, 2021
  • 5 locations
Assessing Induction of Double Strand Breaks With Androgen Receptor Partial Agonist in Patients on Androgen Suppression

central androgen suppression and brachytherapy.

androgens
androgen suppression
brachytherapy
flutamide
  • 0 views
  • 25 Jan, 2021
  • 1 location
A Multi-Center Trial of Androgen Suppression With Abiraterone Acetate Leuprolide PARP Inhibition and Stereotactic Body Radiotherapy in Prostate Cancer

The purpose of this study is to establish the maximum tolerable dose of niraparib when combined with prostate stereotactic body radiotherapy (SBRT), abiraterone, leuprolide, and prednisone (the phase 1 portion of the study) and determine 3-year biochemical PSA recurrence free-survival with this treatment approach (the phase 2 portion of the …

adenocarcinoma
androgen suppression
androgens
leuprolide
prednisone
  • 0 views
  • 24 Feb, 2021
  • 1 location
Hormonal Intervention for the Treatment in Veterans With COVID-19 Requiring Hospitalization

The purpose of this study is to determine if temporary androgen suppression improves the clinical outcomes of Veterans who are hospitalized to an acute care ward due to COVID-19.

COPD
covid-19
diabetes
SARS
cancer
  • 409 views
  • 15 Mar, 2021
  • 16 locations
Optimizing Prostate Cancer Treatment in Men With Advanced Local Disease

not compromising the unprecedented high cure rates obtained for the brachytherapy arm of the Androgen Suppression Combined with Elective Nodal and Dose Escalated Radiation Therapy (ASCENDE-RT

bone scan
transrectal ultrasound
androgens
ct scan
external beam radiation therapy
  • 18 views
  • 24 Jan, 2021
  • 1 location
Randomized Phase II Trial of Salvage Radiotherapy for Prostate Cancer In 4 Weeks v. 2 Weeks

The purpose of this study is to compare urinary and bowel side effects of hypofractionated radiotherapy in 20 treatments (4 weeks) to ultra-hypofractionated radiotherapy in 5 treatments (2 weeks) for prostate cancer that has returned after prostatectomy. The investigators are also interested in looking at time to progression and the …

prostatectomy
metastasis
hypofractionated radiation therapy
bone scan
  • 0 views
  • 26 Jan, 2021
Postop Hypofractionated Radiation Therapy and LHRH in Patients With Prostate Cancer

Prostate cancer is the second most common cancer among Canadian men of which approximately 20-30% present with high-risk tumour characteristic. Although surgery can be curative in patients evidencing pathological high-risk disease (extracapsular extension, seminal vesicle involvement, positive surgical margins), a large proportion will develop biochemical failure within years from the …

testosterone
ct scan
gonadorelin
adenocarcinoma of prostate
prostate specific antigen
  • 3 views
  • 23 Jan, 2021
  • 2 locations
Targeted Radiotherapy in Androgen-suppressed Prostate Cancer Patients.

This multi-center, phase II trial will be conducted in men with castration resistant prostate cancer. The aim of the TRAP trial is to test whether a new precise radiotherapy technique called stereotactic body radiotherapy (SBRT) can slow down the growth of metastatic prostate cancer. If SBRT is effective it will …

bone scan
metastasis
castration-resistant prostate cancer
androgens
endocrine therapy
  • 30 views
  • 23 Jan, 2021
  • 6 locations
PR.7 Companion Trial: Effect of Intermittent Versus Continuous Androgen Suppression on Bone Loss and Body Composition

group of 150 patients registered in PR.7 prior to January 1, 2002, randomized between intermittent androgen suppression (IAS) and continuous androgen suppression (CAS) (75 from each

prostatectomy
metastasis
androgens
endocrine therapy
diphosphonates
  • 53 views
  • 07 Nov, 2020
  • 1 location