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Found 254 clinical trials
Improving Treatment of Glioblastoma: Distinguishing Progression From Pseudoprogression

Glioblastoma is the most aggressive kind of brain cancer and leads on average to 20 years of life lost, more than any other cancer. MRI images of the brain are taken before the operation, and every few months after treatment, to see if the cancer regrows. It can be hard …

brain tumor
MRI
tumor progression
cancer
chemoradiotherapy
  • 9 views
  • 28 Mar, 2021
  • 14 locations
Restrictive Use of Dexamethasone in Glioblastoma (RESDEX)

The administration of steroids, most commonly dexamethasone (DEX), has established as standard of care during treatment of glioblastoma (GBM) and is widely used during the entire course of the disease including pre- and postoperative management, chemo- and radiotherapy. The primary purpose is to reduce tumor-associated vasogenic edema and to prevent …

dexamethasone
  • 5 views
  • 30 May, 2022
  • 1 location
Personalized Radiation Therapy for GBM

The study is a pilot study to estimate the efficacy of personalized dose-escalation radiation therapy in patients with glioblastoma, as measured by estimating the median of progression-free survival. Toxicity, patterns of recurrence, and overall median survival will be measured as secondary endpoints. Adverse events will be monitored.

complete resection
karnofsky performance status
chemoradiotherapy
  • 94 views
  • 21 Apr, 2022
  • 1 location
Efficiency of Vaccination With Lysate-loaded Dendritic Cells in Patients With Newly Diagnosed Glioblastoma (GlioVax)

The primary objective of the study is to determine whether overall survival of newly diagnosed glioblastoma patients treated with lysate-loaded, mature dendritic cell vaccines as add-on to the standard of care consisting of resection, radiotherapy with concomitant temozolomide chemotherapy and subsequent adjuvant temozolomide chemotherapy is superior to the treatment with …

MRI
corticosteroids
dexamethasone
temozolomide
karnofsky performance status
  • 55 views
  • 03 Mar, 2022
  • 3 locations
Imaging Perfusion Restrictions From Extracellular Solid Stress - An Open-label Losartan Study (ImPRESS)

An open-label, single institutional phase II trial of losartan in patients with primary and metastatic brain tumors with an individual stepped-wedge, randomized, assessor-blinded, dose-finding design on three indications.

lung cancer
brain tumor
MRI
recurrent glioblastoma
metastasis
  • 0 views
  • 09 May, 2022
  • 1 location
Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM

This research study is studying a new type of vaccine as a possible treatment for patients with glioblastoma. This research study is a Phase I clinical trial, which tests the safety of an investigational intervention and also tries to define the appropriate dose of the intervention to use for further …

tumor cells
MRI
stereotactic biopsy
astrocytoma
corticosteroids
  • 0 views
  • 17 Jun, 2022
ADCTA for Adjuvant Immunotherapy in Standard Treatment of Recurrent Glioblastoma Multiforme (GBM)

To confirm the result of previous Phase I/II and phase II clinical trials, this trial is to test the efficacy and safety of ADCTA immunotherapy plus the standard therapy in comparison with standard therapy alone in patients with recurrent GBM.

MRI
contrast-enhanced magnetic resonance imaging
temozolomide
recurrent glioblastoma
blood urea nitrogen
  • 46 views
  • 27 Feb, 2022
  • 7 locations
Anticancer Therapeutic Vaccination Using Telomerase-derived Universal Cancer Peptides in Glioblastoma (UCPVax-Glio)

Glioblastoma (GBM) is the most frequent primary brain tumor and the brain tumor with the poorest prognosis. The current treatment relies on surgical resection of gross tumor followed by radiochemotherapy and adjuvant therapy with temozolomide. After such therapy, most patients experiment recurrence and few therapeutic option are available. Despite such …

brain tumor
TERT
temozolomide
methylated
cancer
  • 10 views
  • 06 Jun, 2022
  • 4 locations
FDG and FDOPA PET Demonstration of Functional Brain Abnormalities

The purpose of this pilot study will be to conduct a clinical trial using a time-of-flight PET scanner and MRI scanner to test an improved method for differentiating tumor recurrence from radiation necrosis in glioblastoma patients. We will attempt to do so by performing a static and dynamic FDG-PET scan, …

temozolomide
brain tumor
MRI
recurrent tumor
  • 9 views
  • 02 Mar, 2022
  • 1 location
A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging

This clinical trial is for men and women with high-grade gliomas. Glucose (sugar) is thought to be a contributor to tumor growth. The ketogenic diet (a high fat, low carbohydrate diet) and metformin (a drug approved by the Food and Drug Administration to treat type 2 diabetes) are both known …

  • 0 views
  • 29 Dec, 2021
  • 2 locations