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Found 254 clinical trials
Educating Brain Tumor Patients Using Patient-specific Actual-size Three-dimensional Printed Models

Patient education plays an essential role in patient-centered care as it enhances patient satisfaction and information comprehension. However, about 40-80% of the information patients receive from healthcare professionals is forgotten and about half of the information patients remember is incorrect. To give informed consent, patients must be able to understand …

brain tumor
  • 0 views
  • 29 Jul, 2021
  • 1 location
Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma

The purpose of this study is to evaluate whether new metabolic imaging will be useful to physicians and patients with glioblastoma for making treatment decisions and seeing how well various types of treatment work. The goal is to improve the way patient care is managed in the future. If you …

MRI
cancer
renal function test
karnofsky performance status
temozolomide
  • 2 views
  • 25 Mar, 2022
  • 1 location
Nivolumab BMS-986205 and Radiation Therapy With or Without Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

This phase I trial studies the side effects of nivolumab, BMS-986205, and standard radiation therapy with or without temozolomide in treating patients with new diagnosed glioblastoma. Immunotherapy with nivolumab, may induce changes in body?s immune system and may interfere with the ability of tumor cells to grow and spread. BMS-986205 …

MRI
tumour resection
tumor cells
neutrophil count
blood transfusion
  • 0 views
  • 24 Jan, 2021
  • 1 location
A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent Glioblastoma

This is a Phase 1/2 study of selinexor in combination with standard of care (SoC) therapy for newly diagnosed glioblastoma (nGBM) or recurrent glioblastoma (rGBM). This study will be conducted in 2 phases: a Phase 1a dose finding study followed by Phase 1b (dose expansion) and a Phase 2 randomized …

blood transfusion
ccnu
brain tumor
MRI
bevacizumab
  • 40 views
  • 24 Apr, 2022
  • 17 locations
Evaluate the Efficacy and Safety of ADCV01 as an Add-On Treatment for Primary Glioblastoma Multiforme (GBM) Patients

This study is designed with open-label and randomized parallel group to evaluate the efficacy and safety of autologous dendritic cell vaccination (ADCV01) as an add-on treatment for primary glioblastoma multiforme

carmustine
tumor cells
renal function test
brain tumor
carmustine implant
  • 10 views
  • 11 Apr, 2022
  • 3 locations
Bortezomib and Temozolomide in Recurrent Glioblastoma With Unmethylated MGMT Promoter (BORTEM-17) (BORTEM-17)

This phase IB/II trial is designed to investigate the safety and survival benefits for patients with recurrent glioblastoma with unmethylated MGMT promoter treated with Bortezomib and Temozolomide in a specific schedule.

corticosteroids
recurrent tumor
recurrent glioblastoma
blood transfusion
karnofsky performance status
  • 48 views
  • 13 Feb, 2022
  • 2 locations
A Trial of Ipatasertib in Combination With Atezolizumab (IceCAP)

This is a single centre, proof-of-concept phase I trial of atezolizumab in combination with ipatasertib. There are two parts to this study, the dose escalation phase (Part A) and the dose expansion phase (Part B). Part A, will determine the maximum tolerated dose (MTD) and recommended Phase II dose (RP2D). …

serum bilirubin
AKT
measurable disease
cancer
PTEN
  • 131 views
  • 22 Apr, 2022
  • 1 location
OKN-007 in Combination With Adjuvant Temozolomide Chemoradiotherapy for Newly Diagnosed Glioblastoma

This is a pilot study exploring the potential benefit of adding OKN-007 with Temozolomide for treatment in patients with malignant Glioblastoma undergoing adjuvant concomitant radiotherapy. This drug combination is expected to have an anti-cancer effect in patients who have experienced disease progression after first line treatment.

MRI
cancer
chemoradiotherapy
neutrophil count
temozolomide
  • 96 views
  • 07 Jul, 2022
  • 1 location
DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab (DERIVe)

Patients with newly diagnosed glioblastoma will be consented following tumor resection then undergo leukapheresis for harvest of peripheral blood leukocytes for generation of dendritic cells. Subjects will then receive standard of care (planned 6 weeks) radiation therapy (RT) and concurrent temozolomide (TMZ) at a standard targeted dose of 75 mg/m2/day. …

tumour resection
temozolomide
mgmt gene
MRI
  • 12 views
  • 09 Jun, 2022
  • 1 location
Neuro/Sacituzumab Govitecan/Breast Brain Metastasis/Glioblastoma/Ph 0

Single center, non-randomized, Phase 0 study. Sacituzumab Govitecan given preoperatively, followed by craniotomy with surgery or biopsy of brain tumors (GBM and metastatic brain tumors from Breast) and intraoperative tissue collection will follow with contemporaneous CSF (depending on tumor location) and whole blood (serum) sampling.

brain tumor
cancer
renal function test
recurrent glioblastoma
platelet count
  • 1 views
  • 26 May, 2022
  • 1 location