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Found 254 clinical trials
Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma

This is a phase 0/1 dose-escalation trial to determine the maximum tolerated dose of Mycophenolate Mofetil (MMF) when administered with radiation, in patients with glioblastoma or gliosarcoma.

temozolomide
gliosarcoma
mycophenolate mofetil
glioblastoma multiforme
karnofsky performance status
  • 0 views
  • 04 Oct, 2022
  • 1 location
PARP Inhibition for Gliomas (PI-4G or π4g)

The purpose of this study is to determine what effects (good and bad) niraparib has on patients with recurrent brain cancer.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma

This phase I/Ib trial tests the safety, side effects, and best dose of mycophenolate mofetil in combination with temozolomide and/or radiation therapy (standard of care) in treating patients with glioblastoma. Mycophenolate mofetil is an immunosuppressant drug that is typically used to prevent organ rejection in transplant recipients. However, mycophenolate mofetil …

aptt
dexamethasone
recurrent glioblastoma
immunohistochemistry
astrocytoma
  • 0 views
  • 07 Oct, 2022
  • 1 location
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S

with advanced or metastatic cancers with high LAT1 expression. The MTD of QBS10072S will be confirmed in patients with relapsed or refractory grade 4 astrocytoma.

measurable disease
solid tumor
kidney function test
carcinoma
cancer, thymic
  • 207 views
  • 01 May, 2022
  • 2 locations
Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)

the treatment of newly diagnosed glioblastoma multiforme (GBM) and refractory anaplastic astrocytoma cancers. Temozolomide is considered experimental because it is not approved by the FDA for

primary cancer
sunitinib
temozolomide
renal function
renal function test
  • 11 views
  • 12 Feb, 2022
  • 4 locations
A Phase I/IIa Study of Cerebraca Wafer Plus Adjuvant Temozolomide (TMZ) in Patients With Recurrent High Grade Glioma

High Grade Glioma. High grade gliomas, glioblastoma multiforme (grade IV) and anaplastic anaplastic astrocytoma (Grade III), are the most comment malignant brain tumor. The cause of gliomas

  • 0 views
  • 04 Oct, 2022
  • 3 locations
Clinical Study of Apatinib Combined With Temozolomide in the Treatment of Uncontrolled or Repeated High-grade Gliomas

. Interstitial astrocytomas and glioblastomas are also called high-grade gliomas, accounting for 77.5% of all gliomas.

  • 0 views
  • 25 Feb, 2022
  • 1 location
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

The primary objective of this phase 1 trial is to determine the maximum tolerated dose (MTD), food effect, safety and tolerability of oral ONC206 in patients with recurrent, primary CNS neoplasms.

medulloblastoma
oligodendroglioma, anaplastic
anaplastic astrocytoma
cns tumor
MRI
  • 10 views
  • 12 Mar, 2022
  • 1 location
International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) (HIT-HGG-2013)

> gliomas glioblastoma WHO grade IV (GBM) diffuse midlineglioma histone 3 K27M mutated WHO grade IV (DMG) anaplastic astrocytoma WHO grade III (AA

temozolomide
epilepsy
glioblastoma multiforme
astrocytoma
malignant glioma
  • 44 views
  • 16 Jun, 2022
  • 50 locations
Phase II Trial of LB100, a Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma

Background The brain is separated from the rest of the blood stream by the blood-brain barrier. This is like a filter that protects the brain. But is also a challenge when medicines need to get into the brain. Researchers want to give the new drug LB100 to people before brain …

gliosarcoma
recurrent glioblastoma
recurrent disease
renal function
platelet count
  • 22 views
  • 19 Sep, 2022
  • 1 location