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Found 254 clinical trials
A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine Versus Selumetinib (NSC# 748727) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) Not Associated With BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)

This phase 3 trial compares the effect of selumetinib versus the standard of care treatment with carboplatin and vincristine (CV) in treating patients with newly diagnosed or previously untreated low-grade glioma (LGG) that does not have a genetic abnormality called BRAFV600E mutation and is not associated with systemic neurofibromatosis type …

giant cell astrocytoma
residual tumor
MRI
hypertensive medications
neutrophil count
  • 14 views
  • 18 Sep, 2022
  • 65 locations
Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant Gliomas

This clinical trial studies the side effects of temporally-modulated pulsed radiation therapy (TMPRT) in patients with IDH-mutant gliomas who have previously received radiation therapy to the brain. TMPRT is a radiation technique in which radiation is delivered in multiple small doses on a specific timed interval, instead of delivering one …

karnofsky performance status
astrocytoma
recurrent tumor
oligodendroglioma
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Phase II Study of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma

manner. To investigate whether the methylation profiles of LGGs differ by tumor location (thalamic/midbrain vs. hypothalamic/optic pathway vs. others) and histologies (pilocytic astrocytoma vs

astrocytoma
pilocytic astrocytoma
pleomorphic xanthoastrocytoma
anticonvulsants
neutrophil count
  • 3 views
  • 23 Sep, 2022
  • 2 locations
Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma

Low-grade glioma (LGG) is a common primary brain tumor in young adults. The infiltrative nature and frequent growth in eloquent area in brain often makes total resection impossible. Until now, no agreement has been achieved on the treatment of LGG without total resection. Post-radiation adjuvant temozolomide (TMZ) is currently the …

temozolomide
complete resection
astrocytoma
primary brain neoplasm
primary brain tumors
  • 37 views
  • 24 Jan, 2021
  • 1 location
Trial of C134 in Patients With Recurrent GBM (C134-HSV-1)

The purpose of this project is to obtain safety information in small groups of individuals, scheduled to receive escalating doses of C134, a cancer killing virus (HSV-1) that has been genetically engineered to safely replicate and kill glioma tumor cells. Safety will be assessed at each dose level before proceeding …

  • 14 views
  • 24 Mar, 2022
  • 1 location
MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

This phase I trial studies best dose and side effects of oncolytic adenovirus DNX-2401 in treating patients with high-grade glioma that has come back (recurrent). Oncolytic adenovirus DNX-2401 is made from the common cold virus that has been changed in the laboratory to make it less likely to cause an …

malignant glioma
cytotoxic drug
MRI
brain tumor
thromboplastin
  • 10 views
  • 04 Oct, 2022
  • 1 location
Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)

This is a multi-center, sequential cohort, open-label, volume and dose escalation study of the safety, tolerability, and distribution of 186RNL given by convection enhanced delivery to patients with recurrent or progressive malignant glioma after standard surgical, radiation, and/or chemotherapy treatment. The study uses a modified Fibonacci dose escalation, followed by …

malignant glioma
temozolomide
bevacizumab
recurrent glioma
glioblastoma multiforme
  • 173 views
  • 04 Oct, 2022
  • 3 locations
Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016)

This trial studies how well fimepinostat works in treating patients with newly diagnosed diffuse intrinsic pontine glioma, or medulloblastoma, or high-grade glioma that have come back. Fimepinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

malignant glioma
myelosuppressive chemotherapy
neutrophil count
seizure disorder
brain tumor
  • 3 views
  • 23 Jul, 2022
  • 21 locations
Phase I Study of APX005M in Pediatric CNS Tumors

This phase I trial studies the side effects and best dose of APX005M in treating younger patients with primary malignant central nervous system tumor that is growing, spreading, or getting worse (progressive), or newly diagnosed diffuse intrinsic pontine glioma. APX005M can trigger activation of B cells, monocytes, and dendritic cells …

cytotoxic chemotherapy
MRI
myelosuppressive chemotherapy
hematopoietic stem cell transplantation
neutrophil count
  • 167 views
  • 04 Oct, 2022
  • 11 locations
Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma (Glio)

This is a 2-part multicenter Phase 1b study designed to test icapamespib in patients with recurrent brain lesions. Part 1 of the trial will be a standard 3 by 3 dose escalation design where different doses are examined. Part 2 will be a dose expansion cohort to further evaluate the …

  • 0 views
  • 30 May, 2022
  • 5 locations