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Found 17 clinical trials
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RTOG-0834: Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial

RTOG-0834: Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial

  • 112 views
  • 08 Nov, 2020
  • 1 location
None
  • 171 views
  • 14 Oct, 2021
  • 129 locations
None
Preoperative CRT With Capecitabine Temozolomide in Patients With LARC

This is a prospective biomarker-stratified, randomised phase II study of preoperative CRT with temozolomide plus capecitabine in patients with locally advanced rectal cancer. The primary endpoint is pathologic complete response rates defined as total regression of the primary tumor. For each cohort of MGMT hypermethylated versus MGMT unmethylated, patients will …

  • 15 views
  • 27 Jan, 2021
  • 1 location
None
gliomasPCV Only in 1p/19q Codeleted Anaplastic Gliomas

Patients with 1p/19q-codeleted anaplastic gliomas treated with RT + PCV are at risk of neurocognitive deterioration. Treating these patients with PCV alone (could reduce the risk of

  • 9 views
  • 21 Jan, 2021
  • 1 location
None
Customized Neuro-Imaging Referenced Symptom Video for the Reduction of Patient and Caregiver Anxiety Around Radiation Treatment for Brain Tumors

This trial studies whether a customized video intervention can help to reduce anxiety in brain cancer patients undergoing radiation treatment and their caregivers. A customized neuro-imaging referenced symptom video that describes symptoms and side effects specific to the patients' tumor may result in an early and sustained reduction in anxiety …

MRI
cancer
malignant brain tumor
brain tumor
  • 0 views
  • 25 Jan, 2021
None
Intensity-Modulated Stereotactic Radiation Therapy in Treating Patients With Grade II-IV Glioma

This phase II trial studies how well intensity-modulated stereotactic radiation therapy works in treating patients with grade II-IV glioma. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue.

karnofsky performance status
  • 1 views
  • 15 Jun, 2021
  • 1 location
None
ONC206 for Treatment of Newly Diagnosed or Recurrent Diffuse Midline Gliomas and Other Recurrent Malignant Brain Tumors (PNOC 023)

This phase I trial studies the effects and best dose of ONC206 alone or in combination with radiation therapy in treating patients with diffuse midline gliomas that is newly diagnosed or has come back (recurrent) or other recurrent primary malignant brain tumors. ONC206 is a recently discovered compound that may …

tumor cells
temozolomide
brain tumor
cytotoxic chemotherapy
MRI
  • 0 views
  • 01 Sep, 2021
  • 1 location
None
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

This randomized phase II clinical trial studies the side effects and how well proton beam or intensity-modulated radiation therapy works in preserving brain function in patients with IDH mutant grade II or III glioma. Proton beam radiation therapy uses tiny charged particles to deliver radiation directly to the tumor and …

oligoastrocytoma
temozolomide
step 2
blood transfusion
x-rays
  • 38 views
  • 23 Sep, 2021
  • 14 locations
None
Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma

This phase I trial studies the side effects and best dose of memory-enriched T cells in treating patients with grade II-IV glioma that has come back (recurrent) or does not respond to treatment (refractory). Memory enriched T cells such as HER2(EQ)BB/CD19t+ T cells may enter and express its genes in …

tumor cells
cellular therapy
erbb2
cytotoxic chemotherapy
dexamethasone
  • 100 views
  • 22 Aug, 2021
  • 3 locations
None
Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

This phase II trial studies how well the combination of dabrafenib and trametinib works after radiation therapy in children and young adults with high grade glioma who have a genetic change called BRAF V600 mutation. Radiation therapy uses high energy rays to kill tumor cells and reduce the size of …

astrocytoma, anaplastic
glomerular filtration rate
tumor cells
anaplastic astrocytoma
trametinib
  • 129 views
  • 13 Oct, 2021
  • 57 locations