Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 34 clinical trials
Interleukin-1 Blockade in Acute Myocardial Infarction to Prevent Heart Failure (Virginia-ART4)

(inflammation) during a heart attack may be contributing to the risk of heart failure. The current study will test the ability of an anti-inflammatory medicine (anakinra) to block the inflammation in the body

myocardial infarction
heart failure
infarct
  • 0 views
  • 17 Jun, 2022
  • 1 location
Biologic Therapy to Prevent Osteoarthritis After ACL Injury

at 10 days post-injury. Group 2 will receive aspiration of the knee hemarthrosis as described in group 1 as well as intra-articular administration of 150mg (~5mls) of anakinra (rhIL-1Ra) within 7

  • 0 views
  • 15 May, 2021
  • 1 location
MIS-C Comparative Effectiveness Study (MISTIC)

In March 2020, children exposed to the virus that causes the COVID-19 illness, SARS-CoV-2, presented with fever and significant inflammation about a month after exposure to the virus. Some children were sick enough to require care in the intensive care unit for what came to be known as Multisystem Inflammatory …

  • 0 views
  • 22 Apr, 2022
  • 1 location
Stem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM)

Type 1 diabetes is an autoimmune disease characterized by destruction of pancreatic beta-cells, resulting in absolute deficiency of insulin. Presently there is no known cure. Our proposed interventional trial is based on 'immunological reset' approach: T-depletion therapy and anti-inflammatory treatment will restore self-tolerance in T1DM; Autologous, peripheral-blood mobilized hematopoietic CD34+-enriched …

insulin
liraglutide
diabetes
etanercept
c-peptide
  • 159 views
  • 24 Apr, 2022
  • 1 location
Personalized Immunotherapy in Sepsis

im of ImmunoSep is to assess whether personalized adjunctive immunotherapy directed against a state of either fulminant hyper-inflammation or immunoparalysis is able to change sepsis outcomes. Patients will be selected by a panel of biomarkers and laboratory findings and will be allocated to placebo or immunotherapy treatment according to their …

pneumonia
bacteremia
organ failure
  • 0 views
  • 23 Aug, 2021
  • 17 locations
Randomised Evaluation of COVID-19 Therapy (RECOVERY) in Children With PIMS-TS in Switzerland (SWISSPED-RECOVERY)

The study is to provide reliable estimates of the effect of study treatment on hospital length of stay through to 28 days after randomisation. The protocol describes an overarching trial design to provide reliable evidence on the efficacy of candidate therapies for children hospitalised with PIMS-TS. It is an adaptive …

  • 1 views
  • 25 May, 2022
  • 10 locations
Canakinumab for the Treatment of Postprandial Hypoglycemia (CanpHy)

The primary objective of this randomized trial is to test whether a treatment with canakinumab is superior to placebo in patients with postprandial hypoglycemia after bariatric surgery, that is if it improves health related quality of life (mentally or physically) or reduces the risk of hypoglycemic events.

  • 0 views
  • 15 Jun, 2022
  • 1 location
IL-1-receptor Antagonist During Cephalic Phase of Insulin Secretion in Health and Type 2 Diabetes (Cephalira)

A prospective, randomized, mixed double- and single-blinded, placebo-controlled, cross-over clinical trial to test whether acute treatment with an IL-1 receptor antagonist impacts insulin secretion over time during the cephalic phase, defined as the first 10 minutes after the first sensorial contact to food, in healthy individuals in healthy humans (Group …

diabetes
type 2 diabetes mellitus
Accepts healthy volunteers
anakinra
hemoglobin a1c
  • 0 views
  • 25 Feb, 2022
  • 1 location
Discovery and Analytical Validation of Inflammatory Bio-signatures of the Human Pain Experience

The first objective of the study is to evaluate whether a novel bio-signature (derived from a wide range of pro- and anti-nociceptive IL-1 family cytokine activity) will predict pain experienced and also release of underlying endogenous opioid neurotransmitters during an experimental nociceptive pain challenge, which will be performed while simultaneously …

Accepts healthy volunteers
opioid
  • 0 views
  • 24 Mar, 2022
  • 1 location
Islet Transplantation Using PKX-001

Islet Transplantation is a procedure used in people with difficult to control Type 1 Diabetes. Insulin producing cells (islets) are isolated from a deceased donor pancreas. After the cells are carefully isolated from the donor pancreas, the islets are transplanted into the recipient's liver. These transplanted islets may produce insulin. …

treatment regimen
diabetic ketoacidosis
type 1 diabetes mellitus
diabetes
severe hypoglycaemia
  • 86 views
  • 08 Jun, 2022
  • 1 location