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Found 152 clinical trials
Featured trial
Methodology Study of Novel Electrophysiological, Physical, and Imaging Outcome Measures to Assess the Progression of Amyotrophic Lateral Sclerosis

Methodology Study of Novel Electrophysiological, Physical, and Imaging Outcome Measures to Assess the Progression of Amyotrophic Lateral Sclerosis

  • 200 views
  • 23 Nov, 2020
  • 1 location
Featured trial
New Approaches to Dementia Heterogeneity.

This study is looking for adults who have mild cognitive impairment, Alzheimer’s, or other forms of dementia. The study is also looking for people with normal cognition, as a comparison. The study is interested in the ways that brain function changes over time with the goal of improving the ability to diagnose …

multiple sclerosis
dementia, frontotemporal
depression
dementia
stroke
  • 149 views
  • 25 May, 2021
  • 1 location
A Study of BIIB067 When Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation (ATLAS)

initiated prior to versus at the time of emergence of clinically manifest amyotrophic lateral sclerosis (ALS).

  • 8 views
  • 30 Apr, 2022
  • 23 locations
Social Cognition in Patients With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis, also known as Charcot disease, is a neurodegenerative disease evidenced by gradual paralysis of the muscles involved in voluntary motor function. The clinical

  • 0 views
  • 27 Jan, 2021
  • 1 location
Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS

To evaluate and compare the efficacy of two dosing regimens of oral edaravone in subjects with amyotrophic lateral sclerosis (ALS), based on the time from the randomization date in Study MT-1186

  • 0 views
  • 05 May, 2022
  • 7 locations
RT001 in Amyotrophic Lateral Sclerosis

RT001-014 is a Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Assess Efficacy, Long Term Safety and Tolerability of RT001 in Subjects with Amyotrophic Lateral Sclerosis

primary lateral sclerosis
  • 1 views
  • 19 Apr, 2022
  • 4 locations
Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis Treatment (Phoenix)

The Phoenix Trial is a randomized double blind placebo controlled Phase III trial to evaluate the safety and efficacy of AMX0035 for treatment of ALS

primary lateral sclerosis
treatment regimen
edaravone
riluzole
  • 0 views
  • 15 May, 2022
  • 22 locations
A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS)

The purpose of this Multiple Ascending Dose (MAD) study is to evaluate the safety, tolerability, PK, and PD of AP-101 in participants with fALS and sALS.

primary lateral sclerosis
assisted ventilation
edaravone
weakness
riluzole
  • 0 views
  • 24 Apr, 2022
  • 7 locations
A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis (ADORE)

Multicenter, multinational, double-blind, randomized (2:1), placebo-controlled Phase III study to investigate the efficacy and safety of 100 mg FAB122 once daily as oral formulation in ALS patients.

primary lateral sclerosis
weakness
  • 0 views
  • 22 Mar, 2022
  • 3 locations
Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) (HIMALAYA)

This is a parallel treatment, Phase 2, randomized, double-blind study to assess the efficacy, safety, tolerability, PK, and PD of twice daily (BID) oral SAR443820 compared with placebo in male and female participants,18 to 80 years of age with ALS followed by an openlabel, longterm extension period. Study ACT16970 consists …

primary lateral sclerosis
body mass index
edaravone
riluzole
  • 0 views
  • 29 Apr, 2022
  • 4 locations