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Found 258 clinical trials
Diagnosis of Alzheimer's Disease Using Event Related Potentials

This study evaluates the use of an EEG device using Event Related Potentials to help diagnose Alzheimer's Disease in the outpatient clinical setting.

alzheimer's disease
memory impairment
memory loss
  • 23 Feb, 2022
  • 1 location
Predicting Cognition After DBS for Parkinson's Disease

The aim of the study is to improve estimation of cognitive outcome after STN-DBS in PD in order to avoid risk factors by optimizing peri- and intraoperative management personalize therapeutic strategies for optimal long-term benefit The investigators will test possible predictors (clinical, neuropsychological, neuroimaging, electrophysiological and molecular) for the risk …

brain stimulation
cognitive impairment
  • 09 Feb, 2022
  • 1 location
Biomarkers in Polyradiculoneuropathies (BIP)

The nodes of Ranvier contain ion channels that enable the rapid propagation of the nerve impulse. Cell adhesion molecules and glycolipids play an important role in the formation of the nodes of Ranvier. Antibodies against glycolipids are detected in half of patients with Guillain-Barr syndrome, an acute inflammatory neuropathy affecting …

inflammatory neuropathy
cell adhesion molecules
neuromuscular diseases
  • 24 Feb, 2022
  • 1 location
Atlas of Retinal Imaging in Alzheimer's Study (ARIAS)

The Atlas of Retinal Imaging in Alzheimer's (ARIAS) study is a 5-year study examining the natural history of retinal imaging biomarkers associated with disease risk, disease burden, and disease progression in Alzheimer's disease (AD). The objective of this project is to create a 'gold standard' reference database of structural anatomic …

eye exam
mild cognitive impairment
Accepts healthy volunteers
  • 25 Jan, 2022
  • 3 locations
Tau PET Imaging in the NACC Study Cohort (TPI)

The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET/CT). 18F-AV-1451 is a specialized radioactive PET imaging agent that is able to detect the presence of tau in the brain. In this …

alzheimer's disease
mental deterioration
Accepts healthy volunteers
  • 29 May, 2022
  • 1 location
Longitudinal Study of Mild Cognitive Impairment in Parkinson's Disease (PD-MCI)

Parkinson's disease (PD) is known for its motor symptoms and affects more than 100,000 Canadians. However, PD patients also show cognitive deficits and neuropsychiatric problems that significantly impair their quality of life. The occurrence of dementia in PD is much higher than in the general population. The proposed study will …

motor symptoms
Accepts healthy volunteers
cognitive disorder
cognitive impairment
  • 23 Feb, 2022
  • 1 location
CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease

Alzheimer's disease (AD) is the most common cause of dementia and currently has no disease modifying treatments or simple accurate diagnostic tests. The goal of this project is to study how tau (a protein thought to cause AD) is made, transported and cleared in the human body. Better understanding of …

alzheimer's disease
neurological disorders
Accepts healthy volunteers
neurological disorder
  • 03 May, 2022
  • 1 location
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic Inflammatory and Takotsubo Cardiomyopathy (MEMORY)

Manganese is a calcium analogue which actively enters viable cells with intact calcium-handling mechanisms and its uptake is evident by an increase in MRI-detectable T1 relaxivity of tissues. Mangafodipir is a novel manganese-based magnetic resonance imaging (MRI) contrast medium with unique biophysical properties that are ideal for application to cardiac …

cardiac mri
Accepts healthy volunteers
  • 18 Oct, 2021
  • 1 location