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Found 17 clinical trials
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis: Prospective Registry and Pilot Study

The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac amyloidosis. The second objective of this study is to compare results of non-invasive test …

amyloidosis
depressed
  • 44 views
  • 20 Sep, 2022
  • 1 location
Neuroimaging in Healthy Aging and Senile Dementia (HASD IND) (HASD PIB IND)

resonance imaging (MRI), and computed tomography (CT) imaging. The study involves imaging the brain to detect the presence of amyloid deposits (plaques in the brain). Amyloid is a protein that may be

amyloid
flortaucipir
dementia
alzheimer's disease
pittsburgh compound b
  • 0 views
  • 26 Apr, 2022
  • 1 location
Imaging Biomarkers in Preclinical and Symptomatic AD (ACS PIB IND)

precede the clinical onset of AD. The investigators will be imaging the brain to detect the presence of amyloid deposits (plaques in the brain). Amyloid is a protein that may be related to dementia of

amyloid
dementia
alzheimer's disease
pittsburgh compound b
senile plaques
  • 0 views
  • 24 Jan, 2022
  • 1 location
Exploration of Arrhythmia Burden in Cardiac Amyloidosis Using Implantable Loop Recorders

The overall aim of this study is to improve our understanding of the effects of the build-up of amyloid deposits in the heart, in particular, our understanding of the risk of abnormal heart

cardiac monitoring
  • 0 views
  • 06 Oct, 2021
  • 1 location
BEAM: Brain-Eye Amyloid Memory Study (BEAM)

The main objectives for this study are: To investigate novel, non-invasive ocular measurements including optical coherence tomography and eye tracking in a cross-sectional study of participants with various neurodegenerative dementias against standard cognitive assessments and brain imaging measures; and To assess the potential utility of ocular assessments for early detection …

cytokines
apolipoprotein e
alzheimer's disease
amyloid
brain imaging
  • 32 views
  • 25 Jan, 2022
  • 5 locations
The Mechanism Study of Diabetic Pancreatic Amyloid Deposition on Cognitive Dysfunction in Alzheimer's Disease

Alzheimer's disease (AD) is closely related to diabetes (DM). DM will aggravate the progression of AD, but the specific mechanism has not yet been clarified. Previous study found that a key pathological feature of the pancreas in patients with DM is islet amyloid polypeptide, and there is also islet amyloid …

Accepts healthy volunteers
  • 0 views
  • 29 May, 2022
  • 1 location
Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis (MED-hATTR)

This study measures circulating, misfolded ATTR oligomers in asymptomatic ATTRm amyloidosis genetic carriers longitudinally over five years.

cardiac amyloidosis
hereditary transthyretin amyloidosis
amyloidosis
  • 129 views
  • 09 Apr, 2022
  • 1 location