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Found 258 clinical trials
Hypertension, Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial) (HIPAC)

The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein

angiotensin
hypertension
electrocardiogram
Accepts healthy volunteers
systolic blood pressure
  • 41 views
  • 07 Jul, 2022
  • 1 location
Cardiac Amyloidosis Prevalence and Outcome in Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Implantation (CAMPOS-TAVI)

alone. Amyloidosis, a pathology with multiple etiologies, is a rare condition and its cardiac form (AC) even more (8 to 17 / 100,000 people / year). However, its prevalence is increasing. Some

stenosis
tavi
aortic valve replacement
ejection fraction
transcatheter aortic valve implantation
  • 0 views
  • 05 Jun, 2022
  • 1 location
Neuropathy in Patients Monitored for Wild-type TTR Cardiac Amyloidosis (Non-mutated) (N-SAC)

Transthyretin (TTR) amyloidosis is a rare disabling disorder that can be hereditary or sporadic. Depending on the form, various tissues are affected. While in hereditary cases, neuropathy is

  • 0 views
  • 24 Jul, 2022
  • 1 location
Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis

This phase I/Ia trial finds the best dose and side effects of venetoclax given in combination with ixazomib citrate and dexamethasone in treating patients with light chain amyloidosis that has

  • 0 views
  • 25 Jul, 2022
  • 3 locations
Modeling the Relationships Between Functional Connectivity and Amyloid Deposition in Alzheimer's Disease

MRI may not be able to differentiate. Among patients whose Alzheimer's diseases have not been confirmed, the defects in brain glucose metabolism can predict future amyloid plaque deposition. On the

mild cognitive impairment
demented
neurodegenerative disorders
alzheimer's disease
cognitive impairment
  • 0 views
  • 18 Feb, 2022
  • 1 location
Prevalence of Wild-Type Transthyretin Cardiac Amyloidosis Among Patients Undergoing Carpal Tunnel Release Surgery - A Prospective Study

Patients above the age of 60 will be recruited at their carpal tunnel release surgery. Biopsies will be taken from the wrist and examined for the presence of amyloid protein. A amyloid-positive

  • 0 views
  • 15 Oct, 2021
  • 1 location
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease (ALPS)

Alzheimer's disease, hyperactivation of the hippocampus is thought to be excitotoxic and is shown to leave neurons vulnerable to further amyloid deposition. Synaptic downscaling through SWA may mitigate the

alzheimer's disease
progression of alzheimer's disease
amyloid deposition
Accepts healthy volunteers
dementia
  • 0 views
  • 11 Mar, 2022
  • 1 location
APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma

This is a Phase Ib/II, open-label, multi-center study evaluating the safety, tolerability, efficacy, and PK/ Pharmacodynamics of APG-2575 in combination with Pd/DRd in patients with relapsed/refractory (RR) multiple myeloma (MM). The study consists of dose escalation and dose expansion phases. The study consists of will start with 2 arms noted …

bone marrow procedure
lenalidomide
electrophoresis
dexamethasone
amyloid deposition
  • 0 views
  • 07 Mar, 2022
  • 3 locations
Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)

This study will be conducted to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of NTLA-2001 in participants with hereditary transthyretin amyloidosis with

  • 0 views
  • 06 Jan, 2022
  • 3 locations
Transdermal Trigeminal Electrical Neuromodulation on Mild Cognitive Impairment With Insomnia

structural connectivity as well as sleep parameters evidenced by polysomnography and sleep surveys, with consideration for amyloid positivity and brain-derived neurotrophic factor .

mild cognitive impairment
amyloid deposition
cognitive impairment
polysomnography
amyloid
  • 0 views
  • 23 Mar, 2022
  • 1 location