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Found 257 clinical trials
Effects of Brain Beta-Amyloid on Postoperative Cognition

presence of brain beta-amyloid plaques in non-demented subjects increases postoperative cognitive decline (POCD) in elderly subjects scheduled for hip or knee replacement. The investigators

cognitive decline
dementia
18f-av-45
  • 0 views
  • 30 Jan, 2022
  • 1 location
Brain Energy for Amyloid Transformation in Alzheimer's Disease Study (BEAT-AD)

The Brain Energy for Amyloid Transformation in AD (Alzheimer's disease) or BEAT-AD study will compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild

amyloid
alzheimer's disease
cognitive assessment
amyloidosis
cognitive impairment
  • 10 views
  • 14 Jun, 2022
  • 1 location
Amyloid-beta PET Imaging With 18F-92 in Alzheimer's Disease

Alzheimer's disease is a neurodegenerative disease. Numerous studies have reported that β-amyloid (Aβ) is an important marker for the diagnosis of AD. 18F-92 molecular probe is a novel

memory impairment
Accepts healthy volunteers
alzheimer's disease
amyloid
  • 0 views
  • 24 Jan, 2022
  • 1 location
Plasma P-tau2017 and Quantitative Amyloid PET Imaging

The overall goal of this protocol is to compare amyloid burden assessed by amyloid PET to plasma P-tau217 levels.

amyloid
Accepts healthy volunteers
  • 0 views
  • 25 Jan, 2022
  • 1 location
Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab

remission (CR) rates in relapsed/refractory amyloidosis than historical pomalidomide/dexamethasone treatment.

measurable disease
combination therapy
dexamethasone
platelet count
neutrophil count
  • 0 views
  • 14 Jun, 2022
  • 4 locations
carDIo-ttranSSfOrm nucLEar Imaging Study (DISSOLvE)

The investigators will evaluate the change in myocardial uptake of 99m-technetium pyrophosphate (Tc-99m PYP) tracer on serial planar and SPECT imaging in patients enrolled in the CARDIO-TTRansform clinical trial (NCT04136171).

  • 0 views
  • 16 Mar, 2022
  • 1 location
Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis

This is a single arm, Open-Label, Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) Amyloidosis.

measurable disease
amyloid deposition
bone marrow procedure
  • 0 views
  • 25 Mar, 2022
Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. (CORELIA)

Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in the elderly with high risk of recurrence. The investigators aim to determine the relationship

MRI
amyloid deposition
  • 19 views
  • 28 Feb, 2022
  • 3 locations
A Study to Evaluate Organ Level Uptake Repeatability of 124I AT-01 in Subjects With Systemic Amyloidosis (AT01-001)

subjects with amyloid light chain (AL) or amyloid transthyretin (ATTR) systemic amyloidosis.

nt-probnp
MRI
amyloid deposition
systemic amyloidosis
  • 0 views
  • 21 Mar, 2022
  • 1 location
Comparison of BTD and BCD Based Regimens in the Treatment of AL Amyloidosis

Research Objective:At present, there is no standard therapeutic regimen for monoclonal immunoglobulin light chain (AL) amyloidosis in the world. To compare the efficacy and safety of the

immunoglobulin
bone marrow procedure
dexamethasone
electrophoresis
bortezomib
  • 0 views
  • 26 Jan, 2021
  • 1 location