Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 23 clinical trials
None
A Trial of Doxycycline vs. Standard Supportive Therapy in Newly-diagnosed Cardiac AL Amyloidosis Patients Undergoing Bortezomib-based Therapy

antibodies, the light chains (LC) that form amyloid deposits. Almost every organ, with the exception of the brain, can be affected by AL amyloidosis. The heart is involved in three fourths of patients and is

  • 26 views
  • 28 Jan, 2021
  • 8 locations
None
Assessment of 18F-Florbetaben Whole-body PET for the Detection of Cardiac and Extracardiac Sites of Amyloid Deposits

image not only cardiac but also extra-cardiac sites of amyloid deposits (Clin Nucl Med. 2017;42(1):50-3).

  • 0 views
  • 20 Aug, 2021
  • 1 location
None
Copaxone in Age Related Macular Degeneration

The purpose of the project is to investigate in eyes with dry AMD, the efficacy and safety as preventive therapy of the immunomodulatory substance named copaxone which had been proven as safe and effective agent for a neurodegenerative disease, in arresting the progression as well as the conversion of dry …

age-related macular degeneration
blindness
  • 52 views
  • 07 Nov, 2020
  • 1 location
None
Effect of Radiotherapy on ATTR Cardiac Amyloidosis : a Proof of Concept Study

amyloidosis, to evaluate whether it can successfully reduce the burden of amyloid deposits in the myocardium as assessed by 18F-Amyloid PET.

  • 0 views
  • 16 May, 2021
  • 1 location
None
Molecular Imaging of Primary Amyloid Cardiomyopathy

to visualize cardiac amyloid deposits using advanced imaging methods. The long-term goal of this work is to identify the mechanisms of cardiac dysfunction, in order to guide the development of novel

amyloid deposits
remission
cardiac amyloidosis
heart failure
florbetapir
  • 28 views
  • 30 Sep, 2021
  • 1 location
None
Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.

hospitalization period following the surgery and at 1 year. Alive and re-hospitalization status will be determined. Patients will be classified according to the presence or not of amyloid deposits.

amyloid deposits
cardiac amyloidosis
amyloid deposition
stenosis
MRI
  • 177 views
  • 27 Jan, 2021
  • 8 locations
None
Predictive Value of Biomarkers of the Alzheimer's Disease (AD) in Elderly Patients With New-onset Epilepsy

hyperexcitability and amyloid deposits is bidirectional, the amyloid protein has a pro-seizure effect and the presence of epilepsy increases the amyloid deposits, (iv) in these models, the administration of an

antiepileptics
seizure
neuropsychological test
  • 3 views
  • 23 Jan, 2021
  • 5 locations
None
Effect of Low Dose Radiotherapy on Brain Amyloidosis in the Treatment of Alzheimer's Disease

dose RT radiotherapy to reduce amyloid deposits in the human brain using molecular imaging (18F-Florbetapir) to show the effectiveness of the treatment on the specific target.

amyloidosis
florbetapir
positron emission tomography
cognitive assessment
senile plaques
  • 114 views
  • 09 May, 2021
  • 1 location
None
MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients

Accumulating evidence indicates that inflammation is prominent both in the blood and central nervous system (CNS) of Alzheimer's disease (AD) patients. These data suggest that systemic inflammation plays a crucial role in the cause and effects of AD neuropathology. Capitalizing on the experience from a previous clinical trial with thalidomide, …

thalidomide
cholinesterase inhibitors
cholinesterase
cancer
mental state examination
  • 0 views
  • 04 Jun, 2021
  • 1 location
None
Carpal Tunnel Syndrome and Amyloidosis

Carpal tunnel syndrome has been suggested to be an early sign of amyloidosi. The investigators will evaluate tissue samples obtained from patients undergoing carpal tunnel release surgery for amyloid.

carpal tunnel release
amyloid deposition
amyloid
  • 13 views
  • 23 Jan, 2021
  • 1 location