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Found 20 clinical trials
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis

determine whether CAEL-101, a monoclonal antibody that removes AL amyloid deposits from tissues and organs, improves overall survival and it is safe and well tolerated in patients with stage IIIa AL

plasma cell dyscrasia
bortezomib
hypertension
dexamethasone
amyloid deposits
  • 32 views
  • 09 Aug, 2022
  • 81 locations
A Study to Evaluate the Effectiveness and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis

determine whether CAEL-101, a monoclonal antibody that removes AL amyloid deposits from tissues and organs, improves overall survival and it is safe and well tolerated in patients with stage IIIb AL

plasma cell dyscrasia
bortezomib
hypertension
dexamethasone
amyloid deposits
  • 41 views
  • 09 Apr, 2022
  • 65 locations
Molecular Imaging of Primary Amyloid Cardiomyopathy (MICA)

to visualize cardiac amyloid deposits using advanced imaging methods. The long-term goal of this work is to identify the mechanisms of cardiac dysfunction, in order to guide the development of novel

cardiac mri
cardiac amyloidosis
immunofixation
heart failure
natriuretic peptide
  • 28 views
  • 23 Feb, 2022
  • 1 location
Predictive Value of Biomarkers of the Alzheimer's Disease (AD) in Elderly Patients With New-onset Epilepsy (BIOMALEPSIE)

hyperexcitability and amyloid deposits is bidirectional, the amyloid protein has a pro-seizure effect and the presence of epilepsy increases the amyloid deposits, (iv) in these models, the administration of an

antiepileptics
neuropsychological test
seizure
  • 3 views
  • 24 Feb, 2022
  • 1 location
MCLENA-1: A Clinical Trial for the Assessment of Lenalidomide in Amnestic MCI Patients (MCLENA-1)

Accumulating evidence indicates that inflammation is prominent both in the blood and central nervous system (CNS) of Alzheimer's disease (AD) patients. These data suggest that systemic inflammation plays a crucial role in the cause and effects of AD neuropathology. Capitalizing on the experience from a previous clinical trial with thalidomide, …

mini-mental state examination
albert
mental state examination
neurologic finding
alzheimer's disease
  • 0 views
  • 30 Apr, 2022
  • 1 location
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

The purpose of this study is to assess the safety, tolerability, immunogenicity and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in non-demented adults with Down syndrome.

acetylcholinesterase
memantine
dementia
alzheimer's disease
acetylcholinesterase inhibitor
  • 0 views
  • 24 Jul, 2022
  • 1 location
A Study to Evaluate Organ Level Uptake Repeatability of 124I AT-01 in Subjects With Systemic Amyloidosis (AT01-001)

This study is designed to assess the repeatability of organ-specific quantitation of radiotracer uptake following Positron Emission Tomography/Computed Tomography (PET/CT) imaging of AT- 01 in subjects with amyloid light chain (AL) or amyloid transthyretin (ATTR) systemic amyloidosis.

nt-probnp
systemic amyloidosis
amyloid deposition
MRI
  • 0 views
  • 21 Mar, 2022
  • 1 location
Carpal Tunnel Syndrome and Amyloidosis (AMICAR)

Carpal tunnel syndrome has been suggested to be an early sign of amyloidosi. The investigators will evaluate tissue samples obtained from patients undergoing carpal tunnel release surgery for amyloid.

carpal tunnel release
amyloid deposition
amyloid
  • 13 views
  • 25 Feb, 2022
  • 1 location
Modeling the Relationships Between Functional Connectivity and Amyloid Deposition in Alzheimer's Disease

Glucose is the main energy source of brain. Different neural degenerative diseases such as Parkinson's disease or Alzheimer's disease have shown distinct brain glucose metabolic patterns. FDG-PET is a established non-invasive method to measures cerebral glucose metabolism and can be used to differentiate different types of neurodegenerative diseases that anatomical …

Accepts healthy volunteers
cognitive impairment
mild cognitive impairment
senile plaques
alzheimer's disease
  • 0 views
  • 18 Feb, 2022
  • 1 location
Transdermal Trigeminal Electrical Neuromodulation on Mild Cognitive Impairment With Insomnia

This study aims to validate the safety and impact of transdermal trigeminal electrical neuromodulation(Cefaly) on mild cognitive impairment patients with insomnia on brain functional and structural connectivity as well as sleep parameters evidenced by polysomnography and sleep surveys, with consideration for amyloid positivity and brain-derived neurotrophic factor .

cognitive impairment
mild cognitive impairment
amyloid deposition
amyloid
polysomnography
  • 0 views
  • 23 Mar, 2022
  • 1 location