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Found 32 clinical trials
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Multi-modal Neuroimaging in Alzheimer's Disease

Alzheimer's disease (AD) is a major public health problem due to its socio-economic weight. An early diagnosis of AD is urgently needed as it would constitute a determinant breakthrough from a social, financial and research standpoints. Therefore, the investigators need predictive markers of AD, and neuroimaging is a particularly promising …

mini-mental state examination
early diagnosis
apolipoprotein e
  • 7 views
  • 08 Nov, 2020
  • 1 location
None
Assessment of 18F-Florbetaben Whole-body PET for the Detection of Cardiac and Extracardiac Sites of Amyloid Deposits

Although being classified as a rare disease, cardiac amyloidosis constitutes an increasing cause of heart failure, which is often overlooked and thus poorly managed. Amyloidosis involves deposits of light chain immunoglobulins in the immunoglobulin light chain amyloidosis (AL) type, but it may also be of a hereditary type in mutated …

  • 0 views
  • 20 Aug, 2021
  • 1 location
None
Investigating Gains in Neurocognition in an Intervention Trial of Exercise

This randomized control trial will examine whether a 12 month monitored exercise intervention improves brain health in cognitively normal older adults. This trial will also address several important unanswered questions: (1) Are the recommended public health guidelines of 150 minutes/week of exercise sufficient for improving cognitive performance? (2) Does exercise …

  • 30 views
  • 04 Mar, 2021
  • 4 locations
None
Modeling the Relationships Between Functional Connectivity and Amyloid Deposition in Alzheimer's Disease

including normal controls without cognitive impairment, patients with prodromal AD or AD. The relationship between functional connectivity of FDG-PET and amyloid deposition in different group of patients

cognitive impairment
dementia
amyloidosis
neurodegenerative disorders
senile plaques
  • 0 views
  • 23 Jan, 2021
  • 1 location
None
Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study

determine tau deposition across adults of different ages and assess the relationship of current tau burden to cognitive function and amyloid deposition collected over the previous 10-year interval.

oophorectomy
flortaucipir
amyloidosis
alzheimer's disease
amyloid
  • 9 views
  • 03 Feb, 2021
  • 1 location
None
UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy

The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer [C-11]PiB in participants in the UAB

amyloidosis
cognitive assessment
alzheimer's disease
amyloid
  • 18 views
  • 02 Jul, 2021
  • 1 location
None
Daratumumab Pomalidomide and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab

This study will test the hypothesis that in patients with previous daratumumab exposure, combination therapy of daratumumab, pomalidomide, and dexamethasone (DPd) will yield higher complete remission (CR) rates in relapsed/refractory amyloidosis than historical pomalidomide/dexamethasone treatment.

platelet count
neutrophil count
measurable disease
daratumumab
dexamethasone
  • 0 views
  • 01 Jul, 2021
  • 4 locations
None
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease

Dementia caused by Alzheimer's disease affects approximately 5.6M adults over age 65, with costs expected to rise from $307B to $1.5T over the next 30 years. Behavioral interventions have shown promise for mitigating neurodegeneration and cognitive impairments. Sleep is a modifiable health behavior that is critical for cognition and deteriorates …

Accepts healthy volunteers
  • 0 views
  • 05 Dec, 2021
  • 1 location
None
Prevalence and Post-surgical Outcomes of CARdiac Wild-type TransthyrEtin amyloidoSIs in Elderly Patients With Aortic steNosis Referred for Valvular Replacement.

> Expected results and impact: This study will emphasize how pressure overload stress accelerates and magnifies amyloid deposition usually known to be related to cardiac aging process. It will develop

cardiac amyloidosis
stenosis
amyloid deposition
amyloid deposits
MRI
  • 177 views
  • 27 Jan, 2021
  • 8 locations
None
Multimodal Biomarkers for Diagnosis and Prognosis in CAA

imaging. Study the characteristics of long-term progression of amyloid deposition in CAA patients using the radiological, biochemical and genetic biomarkers. Study the prognosis

  • 0 views
  • 29 Apr, 2021
  • 1 location