Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 29 clinical trials
Modeling the Relationships Between Functional Connectivity and Amyloid Deposition in Alzheimer's Disease

including normal controls without cognitive impairment, patients with prodromal AD or AD. The relationship between functional connectivity of FDG-PET and amyloid deposition in different group of patients

amyloid
cognitive impairment
alzheimer's disease
neurodegenerative disorders
demented
  • 0 views
  • 18 Feb, 2022
  • 1 location
UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy (PiB ADC)

The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer [C-11]PiB in participants in the UAB

amyloid
cognitive assessment
alzheimer's disease
Accepts healthy volunteers
amyloidosis
  • 20 views
  • 15 Jun, 2022
  • 1 location
Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab

This study will test the hypothesis that in patients with previous daratumumab exposure, combination therapy of daratumumab, pomalidomide, and dexamethasone (DPd) will yield higher complete remission (CR) rates in relapsed/refractory amyloidosis than historical pomalidomide/dexamethasone treatment.

dexamethasone
daratumumab
combination therapy
neutrophil count
measurable disease
  • 0 views
  • 14 Jun, 2022
  • 4 locations
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease (ALPS)

Alzheimer's disease, hyperactivation of the hippocampus is thought to be excitotoxic and is shown to leave neurons vulnerable to further amyloid deposition. Synaptic downscaling through SWA may mitigate the

amyloid
alzheimer's disease
amyloid deposition
progression of alzheimer's disease
Accepts healthy volunteers
  • 0 views
  • 11 Mar, 2022
  • 1 location
Transdermal Trigeminal Electrical Neuromodulation on Mild Cognitive Impairment With Insomnia

This study aims to validate the safety and impact of transdermal trigeminal electrical neuromodulation(Cefaly) on mild cognitive impairment patients with insomnia on brain functional and structural connectivity as well as sleep parameters evidenced by polysomnography and sleep surveys, with consideration for amyloid positivity and brain-derived neurotrophic factor .

polysomnography
amyloid
cognitive impairment
mild cognitive impairment
amyloid deposition
  • 0 views
  • 23 Mar, 2022
  • 1 location
Neuroinflammation and Age-associated Brain Pathology: Two Potential Mechanisms of Cognitive Impairment in Breast Cancer

mechanisms, neuroinflammation and amyloid deposition, that have been suggested in other age-related cognitive disorders. This study may help physicians and researchers develop new treatments to protect the

taxane
  • 0 views
  • 13 Jun, 2022
  • 1 location
Hyperbaric Oxygen Therapy for Prodromal Alzheimer´s Disease With Cerebrovascular Disease

factors. The Amyloid deposition, which serves as the biological marker of AD, was originally thought to be the main cause of the disease, however, recent data suggests that it is not the cause and that it

  • 0 views
  • 10 Aug, 2022
  • 1 location
Amyloid Plaque Deposition in Chemotherapy-Induced Cognitive Impairment

resulting in cognitive dysfunction. These imaging assessments will make it possible to explore any altered changes in cerebral structure, metabolism, and amyloid deposition that may be responsible for CICI

adjuvant chemotherapy
immunostimulant
  • 1 views
  • 25 Mar, 2022
  • 1 location
Topography Staging and Dual Phase Image Quantification of Tau PET in Cognitive Impairment Subjects

A second-generation tau PET image tracer 18F-PM-PBB3 (APN-1607 or MNI-958) has been developed by National Institute of Radiological Sciences. The new tracer solved the off-target binding issue. This study will evaluate new quantitative methods with PMPBB3, by utilized dual phase scanning protocol to extract blood flow and Tau protein binding …

amyloid
cognitive impairment
cognitive assessment
demented
Accepts healthy volunteers
  • 1 views
  • 18 Feb, 2022
  • 1 location
The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's (LUCINDA)

The LUCINDA Trial is a three-site, phase II, randomized, double-blind, placebo-controlled study of leuprolide acetate (Eligard) in women with Mild Cognitive Impairment or Alzheimer's Disease taking a stable dose of donepezil (Aricept.) Its objective is to assess the efficacy of a 48-week regimen of leuprolide (22.5 mg per 12 weeks) …

cognitive impairment
alzheimer's disease
donepezil
mini-mental state examination
dementia
  • 47 views
  • 28 Feb, 2022
  • 1 location