Found 260 clinical trials
Hypertension Intracranial Pulsatility and Brain Amyloid-beta Accumulation in Older Adults (HIPAC Trial)
The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein
- 98 views
- 21 Mar, 2022
- 1 location
A PHASE III, MULTICENTER, RANDOMIZED, PARALLEL-GROUP, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF GANTENERUMAB IN PARTICIPANTS AT RISK FOR OR AT THE EARLIEST STAGES OF ALZHEIMER’S DISEASE
This study is designed to evaluate the efficacy and safety of Gantenerumab in participants at risk for or at the earliest stages of Alzheimer’s Disease (AD)
- 0 views
- 17 May, 2022
- 1 location
B3461087 - Tafamidis
This study is a global, multi-center study designed to estimate the global prevalence of transthyretin amyloid cardiomyopathy (ATTR-CM) within a clinically at risk population [participants with
- 0 views
- 05 Apr, 2022
- 5 locations
Impact of sleep apnea and its treatment on memory and tau accumulation in the brain
may be a modifiable risk factor for AD. This study will build on that by evaluating the effect of PAP treatment on markers of AD, such as amyloid beta (Aβ), Tau levels, and neurofilament light chain
- 0 views
- 25 Mar, 2022
- 1 location
A Randomized, Double-Blinded, Placebo-Controlled Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB037 in Subjects With Prodromal or Mild Alzheimer's Disease
A Randomized, Double-Blinded, Placebo-Controlled Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB037 in Subjects With Prodromal or Mild Alzheimer's Disease
- 87 views
- 25 Mar, 2021
- 1 location
Proteins and Brain Networks in Atypical Alzheimer's Disease
Participants will take part in 2-4 study visits including detailed history and neurological exam, pen-&-paper cognitive testing, and functional MRI and PET scans designed to help us understand how different forms of Alzheimer's disease affect brain circuits over time.
- 53 views
- 24 Jan, 2022
- 1 location
A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose Regimen-finding Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects With Early Alzheimer's Disease
A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose Regimen-finding Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects With Early Alzheimer's Disease
- 258 views
- 08 Dec, 2020
- 1 location
Cognitive Impairment Registry
The purpose of this study is to develop a recruitment registry of potential drug study participants who may have amyloid, a specific biomarker for Alzheimer's disease, using a phone assessment
- 637 views
- 17 May, 2022
- 1 location
- Online study
First-in-Human Study of NI006 in Patients With Amyloid Transthyretin Cardiomyopathy
extension phase in subjects with Amyloid Transthyretin Cardiomyopathy (ATTR-CM).
- 34 views
- 21 Apr, 2022
- 6 locations
Study on Early Brain Injury Mechanism and Comprehensive Intervention of VCI
Commun in 2016 shows that the early pathological changes of AD may not be a cascade of amyloid protein (A), but a decrease in cerebral blood flow. Therefore, this project intends to establish an early
- 21 views
- 19 Aug, 2021
- 1 location