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Found 9 clinical trials
Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia (ACACIA)

> Survival will also be evaluated by CrAg titer (comparing high titers who received Liposomal Amphotericin B (L-AMB) to high titers who received fluconazole alone), safety, tolerability, and cost

HIV Infection
amphotericin b
antifungal therapy
antifungal
amphotericin
  • 0 views
  • 26 Feb, 2022
  • 1 location
Azole-echinocandin Combination Therapy for Invasive Aspergillosis

The goals of this study are 3-fold: First, the main study and the primary endpoint will evaluate if the overall mortality can be decreased with initial azole-echinocandin combination therapy compared with triazole monotherapy in patients with IA and documented voriconazole susceptibility. Second, the study design described will also allow to …

  • 0 views
  • 16 Oct, 2021
  • 4 locations
Chronic Pulmonary Aspergillosis and Ambisome Aerosol With Itraconazole

This study compares the therapeutic (clinical and radiological) efficacy of a six-month treatment by itraconazole and nebulised Ambisome® (liposomal amphotericin B = LAmB) versus treatment by

  • 16 views
  • 23 Mar, 2022
  • 1 location
Nebulised Liposomal Amphotericin for Invasive Pulmonary Aspergillosis (NAIFI01 Study) (NAIFI01)

The investigators aim to assess the safety and efficacy of nebulized liposomal amphotericin B (ALN) as a complementary therapy to the usual systemic treatment in patients with invasive pulmonary

  • 38 views
  • 27 Feb, 2022
  • 1 location
Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial (EnACT) (EnACT)

This study is designed as two sequential trials. The first is a phase I open label trial to evaluate the safety and tolerability of MAT2203. The maximal tolerated and non-toxic daily dose,will then be moved forward into a multi-day safety trial. The Phase II trial will investigate toxicity and early …

amphotericin b
csf cryptococcal antigen
mat2203
flucytosine
amphotericin
  • 124 views
  • 14 Mar, 2022
  • 1 location
De-escalation - Antifungal Treatment Immunocompromised Patients (D-ATFIM)

within the 5 days following their initiation. The three antifungals considered in this study are from the narrowest to the widest spectrum: fluconazole, caspofungin and liposomal amphotericin B.

antifungal agents
amphotericin b
critically ill
fungal infection
candida infection
  • 0 views
  • 09 Feb, 2022
  • 1 location
Diagnosis and Treatment of Leishmania Infections

leishmaniasis similar to tuberculin skin testing. Treatment and length of hospital stay are determined by the type of infection. CL may be treated with Pentostam, amphotericin, amphotericin B

miltefosine
skin test
electrocardiogram
cutaneous leishmaniasis
withdrawn
  • 21 views
  • 01 Jul, 2022
  • 1 location
Pharmacokinetics of Isavuconazole in Patients in the Intensive Care Unit (ICONIC)

20 patients admitted to the ICU department and receiving isavuconazole as part of standard care for the treatment of fungal infections will be included in the study. Between day 3 and 7, 8 samples will be collected at t = 0 (pre-dose), and t = 0.5, 1, 2, 4, 6, …

  • 0 views
  • 06 Jun, 2022
  • 4 locations
Individualized Diagnosis of Endocarditis and Its Therapy With a Focus on Infected Prosthetic materiAL (IDENTICAL)

Infective endocarditis (IE) is a frequent and serious complication of implanted intracardiac prosthetic material, with a high morbidity and mortality. Therefore, this study aims to improve outcome of IE, with a focus on patients with intracardiac prosthetic material. In this study the investigators deal with research questions about both the …

  • 9 views
  • 23 Feb, 2022
  • 1 location