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Found 63 clinical trials
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Pilot Feasibility Study of Combined Kidney and Hematopoietic Stem Cell Transplantation to Cure End-stage Renal Disease

This pilot study of combined kidney and hematopoietic stem cell transplantation attempts to establish a protocol to induce immunological tolerance as a new strategy to prevent renal graft rejection. If successful, this strategy would restore renal function, while avoiding the risks associated with long-term standard anti-rejection therapy, and would represent …

kidney transplant
immunosuppression
nephropathy
  • 60 views
  • 07 Dec, 2021
  • 1 location
None
Initial Management of MRONJ Stages I and II a Clinical Trial With Detection of Salivary Biomarkers

Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients receiving antiresorptive therapies, such as Bisphosphonates and Denosumab. It is defined by the presence of exposed bone or a fistula that probes bone in the jaws for a period greater than 8 weeks in patient with a history …

  • 0 views
  • 24 Feb, 2021
  • 1 location
None
Digital Occlusal Wafer Versus Waferless Distal Segment Repositioning for BSSO in Skeletal Mandibular Deformities

Research studies continues to attempt testing modifications to refine the treatment protocols through computer assisted design or computer-generated surgical Wafer splints, have greatly revolutionized the incorporation of digital imaging and 3D design in Orthognathic surgery. Integrating computer guided technology in orthognathic surgery aims to to simplify workup and reduce surgical …

Accepts healthy volunteers
  • 0 views
  • 15 Dec, 2021
  • 1 location
None
Acquisition of Resistant Enterobacteria During Oral Drug Challenge for Betalactams in Children

Direct drug provocation testing, without prior skin or in vitro testing, is the reference standard for confirming the diagnosis of drug hypersensitivity reactions in children reporting mild and delayed-onset reactions. However, optimal protocol(s) have not been standardized. Although a 2-days' provocation testing protocol is effective, increasing its duration (up to …

  • 0 views
  • 27 May, 2021
  • 1 location
None
The OPTIMAL TDM Study: Determining Optimal Beta-lactam Plasma Concentrations Through Therapeutic Drug Monitoring

plasma concentrations of imipenem, meropenem, amoxicillin, flucloxacillin, piperacillin, ceftazidime and cefepime in patients at increased risk of serious bacterial infections and currently understudied

  • 0 views
  • 02 Jun, 2021
  • 1 location
None
European Registry on the Management of Helicobacter Pylori Infection

The great diversity of regimens and treatment lines, the different efficacy of these, mostly due to the increase in bacterial antibiotic resistance and regional differences, requires a continuous critical analysis of clinical practice, evaluating systematically the efficacy and safety of the different regimens and the cost-effectiveness of the different diagnostic-therapeutic …

antibiotic therapy
antibiotics
gastric cancer
cancer
peptic ulcer
  • 241 views
  • 07 Sep, 2021
  • 30 locations
None
Infections Caused by ESbL-Producing Enterobacteriaceae in Italy

To assess the molecular epidemiology, clinical impact, treatment outcome and risk factors for infections caused by Enterobacteriaceae producing ESBLs in Italy in a large multicenter observational survey. SPECIFIC OBJECTIVES 1. To collect consecutive nonreplicate isolates of Enterobacteriaceae resistant to expanded-spectrum cephalosporins from clinical specimens from inpatients and outpatients. 2. To …

antibiotic therapy
antibiotics
lactam
pneumonia
cephalosporins
  • 21 views
  • 07 Nov, 2020
  • 1 location
None
Renal Tolerance of Amoxicillin and Cloxacillin Combination

investigator's primary purpose is to describe patients treated with high dose Amoxicillin and Cloxacillin combination and to evaluate its renal tolerance.

nephrotoxicity
  • 0 views
  • 10 Dec, 2021
  • 1 location
None
Antibiotic Dosing in Patients on Intermittent Hemodialysis

The adequacy of the currently used dosing regimen of glycopeptides (vancomycin and teicoplanin) and beta-lactam antibiotics (amoxicillin-clavulanic acid, piperacillin-tazobactam, ceftazidim) in

intermittent hemodialysis
  • 0 views
  • 17 Aug, 2021
  • 1 location
None
Antibiotic Dosing in Geriatric Patients at the Emergency Department

In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate, Piperacillin-Tazobactam and Temocillin) are attained in frail patients admitted to the geriatric department.

antibiotic therapy
antibiotics
piperacillin
piperacillin-tazobactam
lactam antibiotics
  • 0 views
  • 17 Jul, 2021
  • 1 location