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Found 15 clinical trials
Glutamatergic Mechanisms of Psychosis and Target Engagement (SA1)

50 healthy volunteers (HV) will participate in 2 identical ketamine-induced pharmacoBOLD (phBOLD) sessions at least 7 days apart. On both days, clinical assessments will be performed following removal of the subject from the scanner. HV will be discharged home after clearance by the study physician. This study will assign ketamine …

Accepts healthy volunteers
  • 96 views
  • 22 Mar, 2022
  • 1 location
Adopting the MRD Strategy to Optimize Post-operation Adjuvant Therapies for Early Stage Breast Cancer (AMENDER)

This study is a prospective, multi-center, open-label cohort study, with 3 years disease free survival(DFS) as the primary endpoint. We optimize post-operation adjuvant therapy for early stage breast cancer based on the MRD strategy: patients with clinical high risk or post-operation 1st MRD tested positive will receive intensive adjuvant therapy, …

  • 0 views
  • 12 May, 2022
  • 2 locations
Efficacy and Safety of MEDI6570 in Patients With a History of Myocardial Infarction (GOLDILOX)

A Phase IIB Parallel group Study to Evaluate the Efficacy and Safety of MEDI6570 in Participants with a Prior Myocardial Infarction.

myocardial infarction
infarct
  • 13 views
  • 15 Jun, 2022
  • 92 locations
Planning Treatment for Oesophago-gastric Cancer: a Maintenance Therapy Trial (PLATFORM)

To evaluate the efficacy of maintenance therapies following completion of standard first-line chemotherapy in patients with locally advanced or metastatic HER-2 positive or HER-2 negative oesophago-gastric adenocarcinomas.

capecitabine
liver metastasis
fluoropyrimidine
neutrophil count
serum bilirubin
  • 0 views
  • 26 Jan, 2022
  • 1 location
Safely Reduce Newborn Antibiotic Exposure With the Early-onset Sepsis Calculator

Newborns are at risk for early-onset sepsis (EOS), which occurs within 72 hours after birth. The incidence of proven EOS is 0.5-2.0 per 1000 live births. The annual birth rate in the Netherlands is around 170.000, consequently the number of EOS cases varies between 85 to 340. However, about 5%, …

  • 0 views
  • 17 Jun, 2022
  • 2 locations
Randomised Evaluation of COVID-19 Therapy (RECOVERY)

RECOVERY is a randomised trial investigating whether treatment with Lopinavir-Ritonavir, Hydroxychloroquine, Corticosteroids, Azithromycin, Colchicine, IV Immunoglobulin (children only), Convalescent plasma, Casirivimab+Imdevimab, Tocilizumab, Aspirin, Baricitinib, Infliximab, Empagliflozin, Sotrovimab, Molnupiravir, Paxlovid or Anakinra (children only) prevents death in patients with COVID-19.

pneumonia
fever
covid-19
ritonavir
cough
  • 0 views
  • 19 Apr, 2022
  • 6 locations
Safety and Anti-leukemic Activity of Vodobatinib (K0706) for Treatment Refractory/Intolerant CML Failing ≥3 Prior CML Therapies

Phase 1/2 study to determine safety, tolerability, pharmacokinetics, and anti-leukemic activity of Vodobatinib (K0706) in treatment-refractory/intolerant CML

ponatinib
  • 32 views
  • 18 May, 2022
  • 52 locations
Add-on MEmaNtine to Dopamine Antagonism to Improve Negative Symptoms at First Psychosis

brain's glutamate system. AMEND is a 12-week, double-blind, placebo-controlled, randomized clinical trial (RCT) testing effects of add-on memantine to initial antipsychotic treatment in never-treated

schizoaffective disorder
delusions
schizophrenia
delusional disorder
antipsychotics
  • 0 views
  • 05 Sep, 2021
  • 1 location
ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea. (AMEND)

> In a pilot study we demonstrated early (6 week) beneficial effects of CPAP in patients with OSA and HF. The current proposal (AMEND) is a unique substudy of the recently funded ADVENT-HF trial

adaptive servo-ventilation
systolic dysfunction
somnolence
medical therapy
excessive daytime sleepiness
  • 48 views
  • 03 Jun, 2022
  • 1 location
Preoperative High-dose Dexamethasone and Emergency Laparotomy

The aim of this trial is to evaluate the effect of high-dose glucocorticoid on inflammatory response and recovery after emergency laparotomy in participants with intestinal obstruction and perforated viscus. Primary outcome is the reduction of C-reactive protein on postoperative day 1. Secondary outcomes are organ specific complications in the post …

  • 0 views
  • 25 Apr, 2022
  • 1 location