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Found 10 clinical trials
Low-Intensity Focused Ultrasound on Individuals With Disorder of Consciousness of Traumatic Brain Injury

Low-intensity focused ultrasound can be effective in severe TBI patients with disorder of consciousness. This study is a prospective single arm, open-label and explorative clinical trial to evaluate the therapeutic effect of recovery from DoC and safety of low-intensity focused ultrasound stimulation at thalamic area in patients with post-traumatic DoC.

  • 0 views
  • 22 Oct, 2021
  • 1 location
Promoting Recovery After STroke With Amantadine (PRESTA)

The investigators aim to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial (RCT). Patients will be randomized post-ischemic or

  • 0 views
  • 15 Mar, 2022
  • 1 location
Efficacy of Amantadine Treatment in COVID-19 Patients

Demonstration of the efficacy of amantadine over placebo in the population of patients with moderate or severe COVID-19 in the initial stage of the disease treated in the hospital

  • 0 views
  • 16 Jul, 2021
  • 2 locations
Acetyl-Amantadine as a Biomarker in Patients With Glioblastoma

limited early detection methods and an absence of effective therapeutic options. The study proposed would establish important evidence for the use of Health Canada approved drugs such as amantadine as a

  • 0 views
  • 24 Feb, 2021
  • 1 location
Amantadine in Treating Cognitive & Motor Impairments in Adolescents and Adults With Cerebral Palsy

determine the effects of Amantadine, a dopaminergic agonist, on cognitive function in adolescents and adults with CP.

cognitive impairment
  • 35 views
  • 27 Feb, 2022
Effect of GOCOVRI (Amantadine, Extended Release Capsules) on Gait in Parkinson's Disease

The purpose of the study is to learn about the effect of GOCOVRI (Amantadine extended release) on activity levels and measures of gait and balance quality in people with Parkinson's disease (PD

dyskinesia
amantadine
levodopa
  • 0 views
  • 25 Jan, 2022
  • 1 location
The Use of Amantadine in the Prevention of Progression and Treatment of COVID-19 Symptoms

The use of amantadine in the prevention of progression and treatment of COVID-19 symptoms in patients infected with the SARS-CoV-2 virus. Multicenter randomized, double-blind, placebo-controlled

  • 0 views
  • 22 Aug, 2021
  • 9 locations
Changes in Glutamatergic Neurotransmission of Severe TBI Patients

)benzonitrile)-positron emission tomography ( [18F]FPEB-PET) at rest and following a short pharmacological challenge with amantadine, an N-methyl-D-aspartate receptor (NMDA-R) antagonist, following L-DOPA, and

amantadine
Accepts healthy volunteers
dopamine
  • 62 views
  • 10 Oct, 2021
Randomized Placebo Controlled Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease. (PIMPARK)

amantadine in pathological gambling is controversial and the efficacy of clozapine has been reported in a few cases but with serious safety limitations. Very recently, naltrexone did not significantly

dopamine agonists
pramipexole
depression
levodopa
impulse control disorder
  • 2 views
  • 25 Mar, 2022
  • 3 locations
Post-stroke Epilepsy: Primary Prophylaxis Study

Advance in stroke treatment have resulted in a dramatic reduction in the stroke mortality, however, the number of stroke survivors living with morbidity has increased significantly. As we know, post-stroke epilepsy has been identified as a significant clinical issue in stroke survivors and stroke is the most common cause of …

  • 0 views
  • 08 May, 2021
  • 1 location