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Found 17 clinical trials
Insulin Resistance in Multiple System Atrophy (IRAMS)

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder. The pathologic hallmark is the accumulation of aggregated alpha-synuclein in oligodendrocytes forming glial

insulin resistance
insulin
Accepts healthy volunteers
alpha-synuclein
  • 5 views
  • 23 Apr, 2022
  • 1 location
[18F]F-DOPA Imaging in Patients With Autonomic Failure

Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia. The anatomical location of

lewy body dementia
atrophy
entacapone
pure autonomic failure
synucleinopathy
  • 19 views
  • 01 May, 2022
  • 1 location
Single-center Pathophysiological Study of the Role of Inflammation, Changes in the Intestinal Epithelial Barrier and the Intestinal Microbiota in Parkinson's Disease (IBIM-Park)

phosphorylated alpha-synuclein will be evaluated by immunohistochemistry. All of these parameters will be correlated with clinical data on the severity of PD: duration of development, age, total Unified

Accepts healthy volunteers
alpha-synuclein
  • 0 views
  • 24 Mar, 2022
  • 1 location
α-synuclein Seeding Activity in the Olfactory Mucosa in COVID-19

Loss of the sense of smell is a characteristic feature of COVID-19 and likely related to viral invasion of the olfactory mucosa but is also a prodromal feature of PD. This constellation has kindled concerns that COVID-19 - similar to the Spanish Flu Pandemic in 1918 - might trigger a …

Accepts healthy volunteers
  • 0 views
  • 17 Jun, 2022
  • 1 location
A Randomized, Double Blind, Placebo-controlled Study to Evaluate the Impact of K0706 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics and Clinical Outcomes in Dementia With Lewy Bodies (DLB)

This study evaluates the safety and tolerability of treatment with K0706 in Dementia with Lewy Bodies (DLB). The hypothesis is that K0706 will be safe and tolerable and that this drug will alter CSF and plasma biomarkers in DLB. Clinical assessments of cognitive, behavioral and motor functioning will also be …

hallucinations
visual hallucinations
mental disorders
acetylcholinesterase
parkinsonism
  • 267 views
  • 21 Oct, 2022
  • 1 location
Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease (Protocol 53136)

REM Behavior Sleep Disorder (RBD) is a sleep disorder causing people to 'act out' their dreams. A high percentage of individuals with idiopathic RBD (iRBD) are known to develop conditions affecting the neurons in the brain such as Parkinson's disease (PD). Based on the increased risk to develop PD, individuals …

metaiodobenzylguanidine
depression
tremor
loss of smell
dopamine
  • 64 views
  • 07 Oct, 2022
  • 1 location
Gut Microbiota in the Progression of Alpha-synucleinopathies

The aim of this study is to correlate baseline gut microbiota features and the progression of neurodegeneration in the established cohort of patients with early Parkinson's disease.

  • 0 views
  • 02 Jun, 2022
  • 1 location
Natural History Study of Synucleinopathies

indicates that abnormal alpha-synuclein deposits have destroyed key areas of the brain involved in the control of movement or cognition. Patients with synucleinopathies and signs of CNS-deficits are

lewy body dementia
atrophy
sexual dysfunction
dizziness
synucleinopathy
  • 768 views
  • 25 Jan, 2022
  • 8 locations
PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT-M)

Progressive Supranuclear Palsy (PSP), Cortico-Basal Degeneration (CBD) and Multiple System Atrophy (MSA) are degenerative brain conditions for which there are currently no curative treatments. To aid the development of new treatment trials, there is a pressing need to develop better methods for diagnosing these conditions early, and to track disease …

parkinsonism
progressive supranuclear palsy
atrophy
mri brain
Accepts healthy volunteers
  • 505 views
  • 25 Jan, 2022
  • 1 location
Biomarkers in Parkinsonian Syndromes (BIOPARK)

the abnormal accumulation of alpha-synuclein, while tau protein accumulates in PSP. The development of biological markers for the diagnosis and prognosis in PD, MSA and PSP remains an unmet need. Such

parkinsonism
tau protein
abnormal protein
progressive supranuclear palsy
atrophy
  • 248 views
  • 19 Apr, 2022
  • 2 locations