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Found 109 clinical trials
Chemotherapy Total Body Irradiation and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

This phase II trial studies how well chemotherapy, total body irradiation, and post-transplant cyclophosphamide work in reducing rates of graft versus host disease in patients with hematologic malignancies undergoing a donor stem cell transplant. Drugs used in the chemotherapy, such as fludarabine phosphate and melphalan hydrochloride, work in different ways …

leukemia
conditioning regimen
anemia
mycophenolate mofetil
hematologic malignancy
  • 45 views
  • 27 Jan, 2021
  • 1 location
Intensity Modulated Total Marrow Irradiation Fludarabine Phosphate and Melphalan in Treating Patients With Relapsed Hematologic Cancers Undergoing a Second Donor Stem Cell Transplant

This phase I trial studies the side effects and the best dose of intensity modulated total marrow irradiation (IMTMI) when given together with fludarabine phosphate and melphalan in treating patients with cancers of the blood (hematologic) that have returned after a period of improvement (relapsed) undergoing a second donor stem …

leukemia
fludarabine
cancer
carbon monoxide
stem cell transplantation
  • 13 views
  • 27 Jan, 2021
  • 1 location
Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity Conditioning Unrelated Mobilized Blood Cell Transplantation

This randomized phase II trial includes a blood stem cell transplant from an unrelated donor to treat blood cancer. The treatment also includes chemotherapy drugs, but in lower doses than conventional (standard) stem cell transplants. The researchers will compare two different drug combinations used to reduce the risk of a …

leukemia
t cell cll
myeloproliferative syndromes
chronic myelomonocytic leukaemia
blast cells
  • 64 views
  • 26 Jan, 2021
  • 1 location
Itacitinib Tacrolimus and Sirolimus for the Prevention of GVHD in Patients With Acute Leukemia Myelodysplastic Syndrome or Myelofibrosis Undergoing Reduced Intensity Conditioning Donor Stem Cell Transplantation

This phase IIa trial studies the side effects of itacitinib when given together with standard treatment (tacrolimus and sirolimus), and to see how well it works in preventing graft-versus-host-disease (GVHD) in patients with acute leukemia, myelodysplastic syndrome or myelofibrosis who are undergoing reduced intensity conditioning donor stem cell transplantation. GVHD …

leukemia
gilbert's syndrome
sirolimus
itacitinib
pulmonary function test
  • 0 views
  • 27 Jan, 2021
  • 1 location
Stem Cell Gene Therapy for Sickle Cell Disease

This Phase I clinical trial will assess the safety and initial evidence for efficacy of an autologous transplant of lentiviral vector modified peripheral blood for adults with severe sickle cell disease.

  • 0 views
  • 27 Jan, 2021
  • 1 location
JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis

This phase II trial studies how well giving a JAK inhibitor before a donor stem cell transplant works in treating patients with myelofibrosis that developed without another condition (primary) or evolved from other bone marrow disorders (secondary). JAK inhibitors are a class of drugs that may stop the growth of …

mycophenolate mofetil
tacrolimus
ruxolitinib
cyclophosphamide
abnormal cells
  • 139 views
  • 03 Feb, 2021
  • 1 location
Galinpepimut-S in Combination With Pembrolizumab in Patients With Selected Advanced Cancers

To evaluate the safety and tolerability of galinpepimut-S in combination with pembrolizumab in patients with selected advanced cancers. Patients will be followed long-term for Overall Survival (OS) and safety. The study will enroll approximately 90 patients and maximum study treatment duration is approximately 2.13 years.

fallopian tube
estrogen
measurable disease
bevacizumab
aptt
  • 120 views
  • 26 Jan, 2021
  • 19 locations
Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

This phase I trial studies the side effects and best dose of ipilimumab when given together with decitabine in treating patients with myelodysplastic syndrome or acute myeloid leukemia that has returned after a period of improvement (relapsed) or does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as …

leukemia
gilbert's syndrome
monoclonal antibodies
remission
blast cells
  • 187 views
  • 04 Mar, 2021
  • 6 locations
Safety and Efficacy Study of Human T Lymphoid Progenitor (HTLP) Injection After Partially HLA Compatible Allogeneic Hematopoietic Stem Cell Transplantation in SCID Patients

The purpose of this study is to evaluate the safety and the efficacy of Human T Lymphoid Progenitor (HTLP) injection to accelerate immune reconstitution after partially HLA compatible allogeneic hematopoietic stem cell transplantation in SCID patients.

  • 0 views
  • 24 Jan, 2021
  • 1 location
Co-transplantation of MSC in the Setting of Allo-HSCT

Mesenchymal stem cells (MSCs) are known to exhibit immunomodulatory, anti-inflammatory, and pro-angiogenic properties, and therefore have the potential to improve the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) .The study is aimed to identify and evaluate the potential benefits of MSCs infusion during allogeneic HSCT, with regard to the …

ejection fraction
graft versus host disease
  • 2 views
  • 23 Jan, 2021
  • 1 location