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Found 109 clinical trials
Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Myelodysplastic Syndrome Low Risk

Comparison of survival in patients with or without a matched donor at 36 months

anemia
blood transfusion
hla-a
lenalidomide
cell transplantation
  • 0 views
  • 26 Jan, 2021
  • 66 locations
RGI-2001 for the Prevention of Acute Graft-vs-Host Disease in Subjects Following Allogeneic Hematopoietic Stem Cell Transplantation

This Phase II open label study will evaluate the safety and efficacy of repeat doses of RGI-2001 in combination with standard of care treatment for the prevention of acute graft-vs-host-disease (aGvHD) in subjects following Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT). These subjects will be compared to contemporary controls.

myeloproliferative disorder
leukemia
allogeneic hematopoietic stem cell transplant
cell transplantation
myeloid leukemia
  • 5 views
  • 24 Jan, 2021
  • 6 locations
Acalabrutinib in CLL and MCL Patients Subjected to Allogeneic Hematopoietic Stem Cell Transplantation (alloSCT)

In this phase II multicenter trial we plan to use acalabrutinib before and after allogeneic hematopoietic stem cell transplantation (alloSCT) with reduced intensity conditioning (RIC) in patients with refractory/relapsed MCL and CLL with poor prognostic factors. Acalabrutinib will be used before alloSCT with the intention to reduce tumor burden and …

  • 0 views
  • 28 Jan, 2021
  • 6 locations
Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

This phase II trial studies how well naive T-cell depletion works in preventing chronic graft-versus-host disease in children and young adults with blood cancers undergoing donor stem cell transplant. Sometimes the transplanted white blood cells from a donor attack the body's normal tissues (called graft versus host disease). Removing a …

blood cell count
fludarabine
induction chemotherapy
cell transplantation
total body irradiation
  • 9 views
  • 06 Mar, 2021
  • 10 locations
Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation

In this study, the investigators test 2 dose levels of thiotepa (5 mg/kg and 10 mg/kg) added to the backbone of targeted reduced dose IV busulfan, fludarabine and rabbit anti-thymocyte globulin (rATG) to determine the minimum effective dose required for reliable engraftment for subjects undergoing hematopoietic stem cell transplantation for …

anemia
undernutrition
stem cell transplantation
anti-thymocyte globulin
thiotepa
  • 176 views
  • 24 Jan, 2021
  • 1 location
HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

This phase I trial studies the side effects and best dose of CD4+ and CD8+ HA-1 T cell receptor (TCR) T cells in treating patients with acute leukemia that persists, has come back (recurrent) or does not respond to treatment (refractory) following donor stem cell transplant. T cell receptor is …

myelodysplastic syndromes
leukemia
residual tumor
fludarabine
myeloid leukemia
  • 71 views
  • 29 Jan, 2021
  • 1 location
Natural History Study of Clinical and Biological Factors Determining Outcomes in Chronic Graft-Versus-Host Disease

hematopoietic stem cell transplant (alloHSCT) in North America and about 50% of patients who are transplanted develop cGVHD. Chronic GVHD is also a disorder that simultaneously affects many organ

  • 1 views
  • 05 Mar, 2021
  • 2 locations
Immunological Follow-up After Allogeneic Hematopoietic Stem Cell Transplantation

Description of the evolution of the biological characteristics of immune blood populations and biomarkers of interest in patients who have received allogeneic hematopoietic stem cell transplantation.

  • 1 views
  • 22 Jan, 2021
  • 1 location
Dendritic Cells in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation

We plan to investigate prospectively and simultaneously skin and blood DC subtypes, their donor/recipient origin and the correlation of DC reconstitution kinetics with treatment, clinical outcome and incidence of aGvHD in patients undergoing allogeneic hematopoietic stem cell transplantation.

cell transplantation
acute graft-versus-host disease
allogeneic hematopoietic stem cell transplant
  • 17 views
  • 07 Nov, 2020
  • 1 location
The Prospective Collection Storage and Reporting of Data on Patients Undergoing Hematopoietic Stem Cell Transplantation Utilizing a Standard Preparative Regimen

To provide the IRB approved mechanism for the prospective collection, analysis and reporting of data on patients who are undergoing either an autologous or allogeneic hematopoietic stem cell

stem cell transplantation
cell transplantation
bone marrow procedure
bone marrow transplant
  • 36 views
  • 27 Jan, 2021
  • 1 location