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Found 99 clinical trials
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Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

Background: Stem cell transplants from related donors (allogenic stem cell transplants) can be used to treat individuals with certain kinds of severe blood diseases or cancers, such as severe anemia. Allogenic stem cell transplants encourage the growth of new bone marrow to replace that of the recipient. Because stem cell …

myelodysplastic syndromes
myelodysplastic syndrome (mds)
anemia studies
anemia
aplastic anemia
  • 86 views
  • 22 Dec, 2020
  • 1 location
TCR +/CD19+ Depleted Allogeneic Hematopoietic Stem Cell Transplantation for Malignant and Non-malignant Disorders

The purpose of this study is to investigate the safety and efficacy of TCR+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) for malignant and non-malignant disorders in

  • 0 views
  • 08 Oct, 2020
  • 1 location
Study of Ipilimumab After Stem Cell Transplantation in People With Relapsed/Refractory Multiple Myeloma

chemotherapy and allogeneic hematopoietic stem cell transplant (AHCT). The investigators also want to find out whether giving ipilimumab after chemotherapy and AHCT is a better way to control the multiple

  • 0 views
  • 28 Nov, 2020
  • 1 location
Biochemical Correction of Severe EB by Allo HSCT and "Off-the-shelf" MSCs

mesenchymal stem cells from a healthy donor will enhance the safety and efficacy of the allogeneic hematopoietic stem cell transplant as well as serve as a source of renewable cells for the treatment of focal

mycophenolate mofetil
stem cell transplantation
allogeneic hematopoietic stem cell transplant
ejection fraction
cyclophosphamide
  • 37 views
  • 21 Nov, 2020
  • 1 location
Oral Supplementation of 2'-Fucosyllactose in Allogeneic Bone Marrow Transplant Recipients

High dose chemotherapy and radiation used as preparative regimens in patients undergoing an allogeneic hematopoietic stem cell transplant (HSCT) disrupts intestinal homeostasis by damaging the

graft versus host disease
acute graft-versus-host disease
allogeneic hematopoietic stem cell transplant
bone marrow transplant
  • 0 views
  • 09 Sep, 2020
  • 1 location
Interleukin-21 (IL-21)- Expanded Natural Killer Cells for Induction of Acute Myeloid Leukemia

Relapsed acute myeloblastic leukemia (AML) requires remission prior to allogeneic Hematopoietic Stem Cell Transplant (HSCT) for optimal survival, but is a disease with poor response to

cytarabine
leukapheresis
filgrastim
colony stimulating factor
gilbert's syndrome
  • 14 views
  • 08 Nov, 2020
Effects of Pulmonary Rehabilitation in Hematopoietic Stem Cell Transplantation Recipients

shown in the literature that inspiratory muscle training in allogeneic hematopoietic stem cell transplant recipients increases functional exercise capacity, inspiratory and expiratory muscle strength

graft versus host disease
allogeneic hematopoietic stem cell transplant
immunosuppression
hereditary diseases
fibrosis
  • 1 views
  • 28 Oct, 2020
  • 1 location
ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma

potential curative treatment remains allogeneic Hematopoietic stem cell transplant (HSCT), as shown by our cohort of 92 newly diagnosed patients who received a sibling tandem auto-allo (HSCT) with an

leukemia
graft versus host disease
measurable disease
plasma cell leukemia
bortezomib
  • 61 views
  • 12 Aug, 2019
  • 2 locations
Co-transplantation of MSC in the Setting of Allo-HSCT

Mesenchymal stem cells (MSCs) are known to exhibit immunomodulatory, anti-inflammatory, and pro-angiogenic properties, and therefore have the potential to improve the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) .The study is aimed to identify and evaluate the potential benefits of MSCs infusion during allogeneic HSCT, with regard to the …

graft versus host disease
ejection fraction
  • 2 views
  • 03 Feb, 2020
  • 1 location
Humor Therapy and Distress After Allogeneic Stem Cell Transplantation

This research study evaluates the impact of a humor intervention on distress (primary outcome), hope, depressive symptoms, anxiety, and pain (secondary outcomes) in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT).

  • 2 views
  • 08 Nov, 2020