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Found 34 clinical trials
Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease

This prospective study will include patients with Vogt-Koyanagi-Harada disease from disease onset, treated with early systemic high-dose corticosteroid and immunosuppressive therapy. Clinical and subclinical signs of disease activity added with electroretinogram exams, through predefined intervals, will be evaluated through a minimum 12-month follow-up.

vogt
  • 1 views
  • 12 Jan, 2022
  • 1 location
Sensation, Motion, and Quality of Life on Natalizumab and Off Natalizumab

The goal of this proposal is to use the BeCare App to (1) determine changes in "Feel Good Effect", or "Restoring Physiologic Homeostasis(RPH)"for individuals with relapsing-remitting MS (RRMS) before and after starting Natalizumab therapy and (2) Compare BeCare-derived with clinically-derived performance metrics.

natalizumab therapy
natalizumab
tysabri
  • 0 views
  • 09 Jan, 2022
  • 1 location
Clonidine to Prevent Delirium After Electroconvulsive Therapy.

Electroconvulsive therapy (ECT) is a highly effective treatment for some psychiatric disorders like major depressive or bipolar disorder, but may lead to agitation and delirium after the procedure in up to 65% of patients. This can have negative side effects and be dangerous for patient and attending staff. Clonidine, a …

electroconvulsive therapy
  • 0 views
  • 03 Jun, 2021
  • 1 location
Construal Level as a Novel Pathway for Affect Regulation and Cancer Control

The objective of the proposed research is to conduct a longitudinal experiment on the neurocognitive pathways and individual differences in high-level construal for affect regulation and smoking cessation. The population is adult smokers aged 25-55 who have tried and failed to quit multiple times and who are experiencing poverty. The …

smoking cessation
cancer
tobacco smoke
primary cancer
  • 0 views
  • 10 Oct, 2021
  • 1 location
Personalization of AntiTB Treatment: Evaluation of Pharmacological Determinants of Treatment Response

The aim of the study is to investigate the possible correlation of plasma drug concentrations with Time To Positivity (TTP) in liquid culture in patients with active pulmonary multi sensitive TB in the first two weeks of treatment. Secondary aims are: the correlation between plasma drug concentrations and hepato/neuro toxicity; …

sputum microscopy
spots
  • 0 views
  • 23 Jan, 2021
  • 1 location
Diagnostic of Chemotherapy Induced Neuropathy in Children

The purpose of this study is to determine the diagnostic accuracy of a newly developed tool (Electrochemical Skin Conductances (ESC) measurement) easy-to-perform, non-invasive, highly reproductible and not requiring specific training, to identify pediatric chemotherapy-induced-peripheral-neuropathies (CIPN). CIPN are a frequent (20 to 75% depending on the drug), early and potentially severe …

bortezomib
vincristine
alkaloids
taxane
neuralgia
  • 0 views
  • 15 Dec, 2021
  • 1 location
Multiple Breath Washout a Clinimetric Dataset

. Multiple breath washout is a potential sensitive test that is a useful readout of disease at these early stages but it lacks standardisation and knowledge of variability with reference to standard lung

bronchiectasis
antibiotic therapy
pulmonary function test
respiratory disease
bronchitis
  • 616 views
  • 23 Jan, 2021
  • 1 location
The Prevalence of Contact Allergies for Wound Dressings In Patients With Diabetic Foot Ulcers (PAID Study)

extent of the burden and risks associated with participation, benefit and group relatedness: An allergy test is standard procedure at Rijnstate Hospital, there is no direct technique-related burden or

diabetic foot
diabetes
contact allergy
foot ulcer
  • 0 views
  • 28 Oct, 2021
  • 1 location
Cetuximab Sensitivity Correlation Between Patient-Derived Organoids and Clinical Response in Colon Cancer Patients.

Eighty patients with RAS/RAF wild-type metastatic right colon cancer will be enrolled and undergo a fresh biopsy of tumor lesion before the standard treatment of chemotherapy. The investigators will establish organoids from the pre-treatment biopsies. Organoids will be exposed to the chemotherapy drugs or chemotherapy drugs combined with cetuximab used …

irinotecan
fluorouracil
cancer
combination therapy
cetuximab
  • 0 views
  • 23 Aug, 2021
  • 1 location
Obstructive Sleep Apnea Among Somali-Americans

The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk …

  • 4 views
  • 17 Sep, 2021
  • 1 location