Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 45 clinical trials
Tolerance by Engaging Antigen During Cellular Homeostasis

Anti-rejection medicines, also known as immunosuppressive drugs, are prescribed to organ transplant recipients to prevent rejection of the new organ. Long-term use of these medicines places transplant recipients at higher risk of serious infections and certain types of cancer. The purpose of this study is to determine if: it is …

kidney transplant
end-stage renal disease
cancer
prednisone
organ transplantation
  • 25 views
  • 24 Jan, 2021
  • 1 location
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

Background Sickle cell disease can often be treated with blood stem cell transplants. But for some people the disease returns. This study will give a second transplant to people whose disease has returned but still have some donor cells in their body. Objective To cure people s sickle cell disease …

sickle cell trait
blood transfusion
apheresis
anemia
priapism
  • 12 views
  • 24 Jan, 2021
  • 1 location
A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC)

The current national acute lymphoblastic leukaemia (ALL) trial in adults investigated whether a low (reduced) intensity chemotherapy regimen prior to transplant could improve the outcome of patients with ALL who are over 40 years of age. The results (60% 2 year survival) are very encouraging but patients who come to …

hla-a
myeloablative conditioning
total body irradiation
transplant conditioning
fludarabine
  • 22 views
  • 24 Jan, 2021
  • 22 locations
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias

People with severe congenital anemias, such as sickle cell anemia and beta-thalassemia, have been cured with bone marrow transplantation (BMT). The procedure, however, is limited to children younger than the age of 16 because the risks are lower for children than for adults. The purpose of this study is to …

iron overload
apheresis
tricuspid regurgitant jet velocity
anemia
acute chest syndrome
  • 95 views
  • 02 May, 2021
  • 1 location
Allogeneic Hematopoietic Stem Cell Transplant for People With Primary Immunodeficiency Diseases

Background During a transplant, blood stem cells from one person are given to someone else. The cells grow into the different cells that make up the immune system. This can cure people with certain immunodeficiencies. But transplant has many risks and complications. Objective To see if stem cell transplant can …

therapeutic agents
total body irradiation
cancer
schwartz
bone marrow procedure
  • 0 views
  • 19 Feb, 2021
  • 1 location
High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) affects white blood cell function. Currently, the only curative treatment is bone marrow transplant to replace the abnormal stem cells with new ones (donor cells) capable of making a normal immune system. Transplant problems include graft versus host disease (GvHD) and graft rejection. With GvHD, donor …

  • 3 views
  • 26 Apr, 2021
  • 1 location
Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant

The ASCENT Trial is a single arm, multi-center, phase II study. The primary objective is to determine the rejection-free, severe graft-versus-host disease (GVHD)-free survival in pediatric patients with serious non-malignant hematologic diseases (NMHD) undergoing mismatched unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) with abatacept added to conventional GVHD prophylaxis. …

acute graft-versus-host disease
anemia
abatacept
mycophenolate
tacrolimus
  • 4 views
  • 25 Jan, 2021
  • 6 locations
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect. We also hypothesize that our mechanistic studies will yield biomarkers that may herald disease recurrence …

systemic sclerosis
mesna
total body irradiation
prednisone
raynaud's syndrome
  • 176 views
  • 27 Jan, 2021
  • 2 locations
Islet Transplantation Using PKX-001

Islet Transplantation is a procedure used in people with difficult to control Type 1 Diabetes. Insulin producing cells (islets) are isolated from a deceased donor pancreas. After the cells are carefully isolated from the donor pancreas, the islets are transplanted into the recipient's liver. These transplanted islets may produce insulin. …

mycophenolate mofetil
diabetes
plasma glucose
pancreatic islet transplantation
immunosuppressive agents
  • 86 views
  • 05 May, 2021
  • 1 location
Reduced Intensity BMT for Immune Dysregulatory and Bone Marrow Failure Syndromes Using Post-Transplant Cyclophosphamide

This is a Phase II prospective trial to assess the rates of donor engraftment using reduced intensity conditioning (RIC) hematopoietic stem cell transplant (HSCT) and post-transplant cyclophosphamide (PTCy) for patients with primary immune deficiencies (PID), immune dysregulatory syndromes (IDS), and inherited bone marrow failure syndromes (IBMFS).

lad-1
forced vital capacity
melphalan
ipex
tacrolimus
  • 0 views
  • 24 Jan, 2021
  • 1 location