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Found 45 clinical trials
Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders

This is a Phase II pilot study to evaluate engraftment and toxicity of patients with non-malignant diseases using a reduced intensity conditioning regimen in the setting of allogeneic transplant for non malignant diseases. Bone Marrow or cord blood will be acceptable as a stem cell source. Recently, reduced intensity conditioning …

reduced intensity conditioning
bone marrow failure
immunodeficiency
transplant conditioning
thalassemia
  • 1 views
  • 14 Mar, 2021
  • 1 location
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

This study is designed to estimate the efficacy and toxicity of familial HLA mismatched bone marrow transplants in patients with non-malignant disease who are less than 21 years of age and could benefit from the procedure.

iron
direct bilirubin
reduced intensity conditioning
blood transfusion
acute chest syndrome
  • 18 views
  • 26 Jan, 2021
  • 1 location
CAMPath and BELimumab for Transplant Tolerance in Sensitized Kidney Transplant Recipients

The purpose of this research study is to determine whether kidney transplant recipients who receive belimumab (Benlysta), combined with the standard of care medications for kidney transplant recipients, is safe and effective in helping prevent new donor specific antibodies (DSA) after transplantation. The presence of DSA increases the risk that …

tubal ligation
campath
hysterectomy
hormone replacement therapy (hrt)
tacrolimus
  • 36 views
  • 15 Mar, 2021
  • 1 location
PK Study in Diabetic Transplant r cipients : From Twice-daily Tacrolimus to Once-daily Extended-release Tacrolimus

The investigators believe that the pharmacological properties of Envarsus, well studied in kidney transplantation, may be also suitable after simultaneous kidney and pancreas transplantation than Prograf. Indeed, Envarsus has demonstrated a clinical efficacy and safety in a complete clinical development plan. This study is to establish the pharmacokinetic profile of …

prograf
chronic kidney disease (ckd)
immunosuppressants
pancreas transplantation
kidney transplant
  • 0 views
  • 25 Jan, 2021
  • 1 location
Reduced Intensity Transplantation for Severe Sickle Cell Disease

This study is being done to test a transplant method that may have fewer side effects (or less toxic, less harmful) than conventional high dose chemotherapy conditioning-based transplants for children and young adults with Sickle Cell Disease (SCD). Patients less than or equal to 25 years old with SCD who …

priapism
acute chest syndrome
cell transplantation
stroke
hemoglobinopathy
  • 0 views
  • 25 Jan, 2021
  • 1 location
Stem Cell Mobilization (Plerixafor) and Immunologic Reset in Type 1 Diabetes (T1DM)

Type 1 diabetes is an autoimmune disease characterized by destruction of pancreatic beta-cells, resulting in absolute deficiency of insulin. Presently there is no known cure. Our proposed interventional trial is based on 'immunological reset' approach: T-depletion therapy and anti-inflammatory treatment will restore self-tolerance in T1DM; Autologous, peripheral-blood mobilized hematopoietic CD34+-enriched …

glp-1
diabetes
insulin
autoimmune disease
immunosuppression
  • 159 views
  • 05 May, 2021
  • 1 location
Decision Making in Multiple Sclerosis Care Under Uncertainty

The main objectives of this study are: i) To determine patient-level, physician-level and health system factors influencing therapeutic decisions in multiple sclerosis (MS) care by applying conjoint discrete experiments. ii) To determine the prevalence of therapeutic inertia among participating neurologists. iii) To compare clinical judgement vs. a qualitative or quantitative …

disease or disorder
fatigue
  • 7 views
  • 23 Jan, 2021
  • 1 location
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective To see if a new transplant regime is effective, safe and well …

x-rays
sirolimus
cyclophosphamide
hydroxyurea
cell transplantation
  • 2 views
  • 05 May, 2021
  • 1 location
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation

This study aims to enroll 58 pre-adolescent (<10 years) pediatric participants with sickle cell disease (SCD) who have a pre-adolescent sibling bone marrow donor. All participants will go through a pre-transplant evaluation to find out if there are health problems that will keep them from being able to receive the …

opioid
blood transfusion
acute chest syndrome
cell transplantation
stroke
  • 23 views
  • 24 Jan, 2021
  • 8 locations
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure

Background Some sickle cell disease or beta-thalassemia can be cured with transplant. Researchers want to test a variation of transplant that uses low dose radiation and a combination of immunosuppressive drugs. They want to know if it helps a body to better accept donor stem cells. Objectives To see if …

blood test
stroke
low dose radiation
beta-hcg
hydroxyurea
  • 43 views
  • 26 Jan, 2021
  • 1 location