Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 36 clinical trials
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective To see if a new transplant regime is effective, safe and well …

campath
x-rays
hydroxyurea
Accepts healthy volunteers
cell transplantation
  • 2 views
  • 20 Sep, 2022
  • 1 location
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation

This study aims to enroll 58 pre-adolescent (<13 years) pediatric participants with sickle cell disease (SCD) who have a pre-adolescent sibling bone marrow donor. All participants will go through a pre-transplant evaluation to find out if there are health problems that will keep them from being able to receive the …

transcranial doppler ultrasonography
chest syndrome
cell transplantation
transplant conditioning
hemoglobinopathy
  • 23 views
  • 12 Feb, 2022
  • 10 locations
Nonmyeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation For Severe Congenital Anemias Including Sickle Cell Disease (SCD) and Beta-Thalassemia

People with severe congenital anemias, such as sickle cell anemia and beta-thalassemia, have been cured with bone marrow transplantation (BMT). The procedure, however, is limited to children younger than the age of 16 because the risks are lower for children than for adults. The purpose of this study is to …

hemoglobin f
anemia
chest syndrome
Accepts healthy volunteers
thalassemia
  • 95 views
  • 20 Sep, 2022
  • 1 location
Tolerance by Engaging Antigen During Cellular Homeostasis (TEACH)

Anti-rejection medicines, also known as immunosuppressive drugs, are prescribed to organ transplant recipients to prevent rejection of the new organ. Long-term use of these medicines places transplant recipients at higher risk of serious infections and certain types of cancer. The purpose of this study is to determine if: it is …

alemtuzumab
end-stage renal disease
kidney transplant
sirolimus
organ transplantation
  • 25 views
  • 26 May, 2022
  • 1 location
A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC) (ALL-RIC)

The current national acute lymphoblastic leukaemia (ALL) trial in adults investigated whether a low (reduced) intensity chemotherapy regimen prior to transplant could improve the outcome of patients with ALL who are over 40 years of age. The results (60% 2 year survival) are very encouraging but patients who come to …

alemtuzumab
fludarabine
blood cell count
transplant conditioning
melphalan
  • 22 views
  • 03 Mar, 2022
  • 9 locations
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

Background Sickle cell disease can often be treated with blood stem cell transplants. But for some people the disease returns. This study will give a second transplant to people whose disease has returned but still have some donor cells in their body. Objective To cure people s sickle cell disease …

sickle hemoglobin
x-rays
anemia
sickle cell trait
chest syndrome
  • 12 views
  • 21 Jul, 2022
  • 1 location
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia in Individuals With Higher Risk of Transplant Failure

Background Some sickle cell disease or beta-thalassemia can be cured with transplant. Researchers want to test a variation of transplant that uses low dose radiation and a combination of immunosuppressive drugs. They want to know if it helps a body to better accept donor stem cells. Objectives To see if …

hemoglobin f
hemoglobin s
chest syndrome
thal
priapism
  • 43 views
  • 18 Sep, 2022
  • 1 location
Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant (ASCENT)

The ASCENT Trial is a single arm, multi-center, phase II study. The primary objective is to determine the rejection-free, severe graft-versus-host disease (GVHD)-free survival in pediatric patients with serious non-malignant hematologic diseases (NMHD) undergoing unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) with abatacept added to conventional GVHD prophylaxis. The …

stroke
anemia
cell transplantation
acute graft-versus-host disease
granulocyte colony stimulating factor
  • 4 views
  • 04 Feb, 2022
  • 6 locations
COVID-19 Booster Vaccination in Persons With Multiple Sclerosis

The success of the U.S. vaccination program against SARS-Cov-2 is shown by a dramatic drop in infection rates, hospitalizations and deaths.However, it appears that many persons who take medications that chronically suppress the immune system do not produce neutralizing antibodies to COVID-19 proteins in response to vaccination. This group includes …

Accepts healthy volunteers
  • 0 views
  • 22 Mar, 2022
  • 1 location
Islet Transplantation Using PKX-001

Islet Transplantation is a procedure used in people with difficult to control Type 1 Diabetes. Insulin producing cells (islets) are isolated from a deceased donor pancreas. After the cells are carefully isolated from the donor pancreas, the islets are transplanted into the recipient's liver. These transplanted islets may produce insulin. …

type 1 diabetes mellitus
hypoglycemic agents
diabetic ketoacidosis
treatment regimen
immunosuppressive agents
  • 86 views
  • 08 Jun, 2022
  • 1 location