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Found 10 clinical trials
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial (RRCT

aldosterone antagonists
n-terminal pro-bnp
spironolactone
atrial fibrillation
b-type natriuretic peptide
  • 46 views
  • 02 Jul, 2021
  • 148 locations
CMR to Assess Fibrosis in Cardiomyopathy Using Eplerenone

The aim of this study is to determine if therapy with the aldosterone antagonist, Eplerenone, is associated with improved remodeling of the left ventricle in patients with cardiomyopathy

fibrosis
aldosterone antagonists
  • 12 views
  • 07 Nov, 2020
  • 1 location
Mineralocorticoid Receptor Antagonist and Pulmonary Fibrosis in COVID-19.

mineralocorticoid receptor antagonist canrenoate potassium (an aldosterone antagonist of the spirolactone group) in the treatment of COVID-19-associated pulmonary fibrosis based on the mechanisms of the immune

  • 0 views
  • 14 Jun, 2021
  • 1 location
Spironolactone Versus Prednisolone in DMD

This is a randomized, open-label, pilot clinical trial of spironolactone suspension versus oral prednisolone for use in Duchenne muscular dystrophy. The goals are to determine the safety of 6 months of treatment with spironolactone treatment int he steroid-naive DMD population as well as to determine if either spironolactone or a …

ejection fraction
prednisolone
corticosteroids
weakness
dmd gene
  • 36 views
  • 23 Jan, 2021
  • 1 location
Recurrent Stroke Prevention Clinical Outcome Study

aldosterone antagonist. The participants will be observed under the BP management for their respective BP target. The study will be continued until the number of patients with the first recurrent

stroke
systolic blood pressure
infarct
recurrent strokes
blood pressure diastolic
  • 5 views
  • 08 Nov, 2020
  • 1 location
Efficacy of Aldosterone Antagonist Therapy for Prevention of New Atrial Fibrillation

The purpose of this study is to accurately determine, using an implantable rhythm monitor, the long-term incidence of new atrial fibrillation after ablation of atrial flutter in those treated with spironolactone compared with standard medical therapy.

aldosterone
heart failure
electrocardiogram
atrial flutter
catheter ablation
  • 5 views
  • 26 Jan, 2021
  • 1 location
Spironolactone Therapy in Chronic Stable Right HF Trial

The purpose of this study is to evaluate the safety, tolerability and mechanistic effects of spironolactone, an aldosterone receptor antagonist, on sympathetic nervous system activity and right heart function and remodeling in patients with chronic right heart failure.

tapse
diuretics
hypertension
spironolactone
cardiac mri
  • 52 views
  • 30 May, 2021
  • 1 location
Renal Sympathetic Denervation for Patients With Chronic Heart Failure

To study whether renal sympathetic denervation(RSD) RSD can slow the progression of CHF and reduce the rate of all-cause mortality effectively and securely.

ejection fraction
  • 0 views
  • 07 Nov, 2020
  • 1 location
Get With The Guidelines-Heart Failure Registry

Get With The Guidelines-Heart Failure is designed to improve the quality of care in patients hospitalized with heart failure. The program aims to help ensure that eligible patients are initiated on guideline recommended therapies and receive appropriate counseling prior to hospital discharge.

congestive heart failure
  • 30 views
  • 23 Jan, 2021
  • 1 location
The Role of Cardiac Mechanics Biomarkers and Frailty in Aortic Stenosis

The role of cardiac mechanics, circulating biomarkers and frailty in predicting outcomes in patients with aortic stenosis after aortic valve replacement (SCRABLES -The 2-Parts Study) Part I: Observational study to characterize phenotypes, structural alterations and biomarkers profiles in a broad spectrum of patients with aortic stenosis and heart failure with …

heart failure with preserved ejection fraction
aortic valve replacement
ejection fraction
  • 12 views
  • 23 Jan, 2021
  • 1 location