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Found 99 clinical trials
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require dialysis. It works by blocking a hormone (aldosterone) in your body that causes

  • 193 views
  • 26 Jan, 2021
  • 98 locations
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction (SPIRRIT)

an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial (RRCT

n-terminal pro-bnp
b-type natriuretic peptide
aldosterone antagonists
natriuretic peptide
pro-brain natriuretic peptide
  • 69 views
  • 01 Mar, 2022
  • 65 locations
Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Inhaled APN01 Developed as Treatment for COVID-19

effectively mimicking ACE2 within the body, APN01 is designed to block the SARS-CoV-2 from binding to the ACE2 receptor and infecting cells while at the same time downregulating the renin-aldosterone

Accepts healthy volunteers
  • 0 views
  • 02 May, 2022
  • 1 location
Effect of MOF on Exercise Blood Pressure

The purpose of this study is to establish an effect of monomeric and oligomeric flavanols supplementation on exercise blood pressure and vascular function in healthy volunteers.

Accepts healthy volunteers
  • 0 views
  • 03 May, 2022
  • 1 location
Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment (CareOnTIME)

This is a controlled, open study designed to compare the effects of dual-release hydrocortisone preparations versus conventional glucocorticoid therapy on clinical, anthropometric parameters, metabolic syndrome, hormonal profile, bone status, quality of life, reproductive, sexual and psychological functions and treatment compliance in patients affected by congenital adrenal hyperplasia due to 21 …

21-ohd
adrenal insufficiency
glucocorticoid therapy
prednisolone
cortisone acetate
  • 56 views
  • 14 Apr, 2022
  • 1 location
The Safety of Dapagliflozin in Hemodialysis Patients With Heart Failure (SDHF)

SGLT2 inhibitor is a new type of sugar-lowering medicine and is recommended to treat heart failure. eGFR lower than 30ml/min/1.73M2 is contraindication of SGLT2 inhibitor. Heart failure is one of the most frequency CVD events for hemodialysis patients. But hemodialysis patient is unable to be treated with SGLT2 inhibitors as …

  • 0 views
  • 15 Mar, 2022
Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome (AUSC)

Incidental findings of adrenal tumours,"incidentalomas", occur in 1-5 % in the general population and 10-25 % of these patients will exhibit biochemical mild hypercortisolism. Although the patients do not have clinical signs of classical Cushing's syndrome, they have an increased risk for hypertension, dyslipidemia, diabetes mellitus, osteoporosis and obesity. The …

  • 30 views
  • 24 Mar, 2022
  • 3 locations
A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease (FIND-CKD)

have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which

  • 0 views
  • 09 May, 2022
  • 173 locations
GOREISAN for Heart Failure (GOREISAN-HF) Trial (GOREISAN-HF)

The objective of the GOREISAN-HF trial is to assess the effect of the administration of Goreisan (TJ-17) plus standard therapy compared to standard therapy alone on the improvement rate of cardiac edema and clinical outcomes in worsening congestive heart failure with volume overload.

congestive heart failure
heart failure
congestion
b-type natriuretic peptide
edema
  • 2 views
  • 27 Apr, 2022
  • 1 location
Management of Angiotensin Inhibitors During the Perioperative Period (AIPOP)

This is a multicenter randomized clinical trial to determine the effect of continuation versus withdrawal of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in the perioperative period on postoperative complications.

hypertension
postoperative complication
  • 0 views
  • 22 Mar, 2022
  • 6 locations