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Found 104 clinical trials
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Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require dialysis. It works by blocking a hormone (aldosterone) in your body that causes

  • 59 views
  • 26 Jan, 2021
  • 98 locations
None
Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

an Aldosterone Antagonist) suggest spironolactone may be effective in HFPEF, but it is generic and will not be studied by industry. SPIRRIT is a unique Registry-Randomized Clinical Trial (RRCT

atrial fibrillation
natriuretic peptide
n-terminal pro-bnp
pro-brain natriuretic peptide
aldosterone antagonists
  • 57 views
  • 02 Jul, 2021
  • 148 locations
None
Aldosterone in Diabetic Nephropathy

The purpose of this study is to determine whether spironolactone are effective in the reduction of albuminuria and diastolic disfunction of subjects with diabetic nephropathy.

spironolactone
nephropathy
diabetic nephropathy
kidney function tests
aldosterone
  • 29 views
  • 07 Nov, 2020
  • 1 location
None
Sodium Diet Effect on Aldosterone and Urinary RNA (SALTY)

This cross-over clinical trial is being conducted to evaluate the difference in urinary messenger RNA (mRNA) biomarkers of mineralocorticoid receptor activation following a low-sodium diet, as compared to a high-sodium diet. The study team will collect urine and blood samples from each participant to study mineralocorticoid receptor-regulated mRNA biomarkers following …

Accepts healthy volunteers
  • 3 views
  • 13 Nov, 2021
  • 1 location
None
Mineralocorticoid Receptor Antagonist and Pulmonary Fibrosis in COVID-19.

mineralocorticoid receptor antagonist canrenoate potassium (an aldosterone antagonist of the spirolactone group) in the treatment of COVID-19-associated pulmonary fibrosis based on the mechanisms of the immune

  • 0 views
  • 14 Jun, 2021
  • 1 location
None
A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients

The purpose of this research study is to compare the effectiveness of hydrochlorothiazide or metolazone in combination with furosemide. Patients with heart failure suffer from swelling because of too much fluid in the body. Furosemide, hydrochlorothiazide, and metolazone are all water pills used to treat the swelling. For most patients, …

beta-adrenergic blocking agents
congestive heart failure
furosemide
edema
diuretics
  • 8 views
  • 07 Nov, 2020
  • 1 location
None
Congenital Adrenal Hyperplasia Once Daily Hydrocortisone Treatment

This is a controlled, open study designed to compare the effects of dual-release hydrocortisone preparations versus conventional glucocorticoid therapy on clinical, anthropometric parameters, metabolic syndrome, hormonal profile, bone status, quality of life, reproductive, sexual and psychological functions and treatment compliance in patients affected by congenital adrenal hyperplasia due to 21 …

metabolic syndrome
glucocorticoid therapy
prednisone
glucocorticoids
prednisolone
  • 56 views
  • 24 Jan, 2021
  • 1 location
None
Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome

Incidental findings of adrenal tumours,"incidentalomas", occur in 1-5 % in the general population and 10-25 % of these patients will exhibit biochemical mild hypercortisolism. Although the patients do not have clinical signs of classical Cushing's syndrome, they have an increased risk for hypertension, dyslipidemia, diabetes mellitus, osteoporosis and obesity. The …

  • 2 views
  • 25 Sep, 2021
  • 8 locations
None
A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease

have long lasting kidney disease, also known as chronic kidney disease (CKD). It works by blocking a certain hormone called aldosterone that causes injury and inflammation in the heart and kidney which

  • 0 views
  • 05 Dec, 2021
  • 266 locations
None
Recurrent Stroke Prevention Clinical Outcome Study

aldosterone antagonist. The participants will be observed under the BP management for their respective BP target. The study will be continued until the number of patients with the first recurrent

recurrent strokes
angiotensin
stroke
hypertensive medication
blood pressure diastolic
  • 5 views
  • 08 Nov, 2020
  • 1 location