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Found 36 clinical trials
A Phase 2b Study in Subjects With Alcoholic Hepatitis to Evaluate Safety and Efficacy of DUR-928 Treatment (AHFIRM)

This is a randomized, double-blind, placebo-controlled, phase 2b clinical Trial evaluating Safety and Efficacy of DUR-928 (an experimental medication) in Patients with Alcoholic Hepatitis (AH

liver disease
  • 0 views
  • 30 Jun, 2022
  • 55 locations
Corticosteroids in Alcoholic Hepatitis

Approximately 50% of patients admitted for severe AH will have spontaneous improvement of liver function before initiation of therapy (ie decrease in mDF between hospital admission and initiation of steroids). These patients have a better prognosis than patients without spontaneous improvement of liver function. It has never been demonstrated that …

  • 0 views
  • 05 Mar, 2021
  • 1 location
Fecal Microbial Transplantation in Severe Alcoholic Hepatitis

A subtype of Alcoholic hepatitis (AH), named severe alcoholic hepatitis (SAH) is associated with high short-term mortality (J Hepatol, 2019) The only SAH treatment option

  • 0 views
  • 25 Feb, 2021
  • 1 location
DUR-928 in Patients With Alcoholic Hepatitis (DUR-928/AH)

The proposed study is An Open-Label, Dose Escalation Study to Assess the Safety, and Pharmacodynamics (PD) signals of DUR 928 in Patients with AH. DUR-928 will be administered in 100 mL 5% dextrose or 0.9% sodium chloride by slow intravenous infusion over 2 hrs (50mL/h) until entire dose is given …

  • 0 views
  • 14 May, 2022
  • 1 location
N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis

Recent data have suggested that monocyte oxidative burst defect is associated with the development of infection in patients with severe alcoholic hepatitis. One report found reduced 28 day

serum bilirubin level
prednisolone
n acetylcysteine
n-acetylcysteine
  • 1 views
  • 16 Nov, 2021
  • 1 location
Fecal Microbiota Therapy in Steroid Ineligible Alcoholic Hepatitis

Alcoholic hepatitis, the most florid form of alcoholic liver disease, has a very high short-term mortality of up to 50% and no specific therapies are available other than steroids. Steroids also

liver disease
  • 0 views
  • 30 Apr, 2022
  • 1 location
Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid

Steroid is the treatment of choice in patients with severe alcoholic hepatitis. However, null- or partial responder of steroid treatment is recommended to consider liver transplantation. The

steroid therapy
g-csf
serum bilirubin level
colony stimulating factor
liver disease
  • 9 views
  • 26 Jan, 2021
  • 1 location
Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH

Given the severe consequences of alcohol relapse following liver transplantation for alcoholic hepatitis (AH-LT), it is critical to accurately identify alcohol use and implement alcohol

  • 0 views
  • 30 Sep, 2021
  • 1 location
Digoxin In Treatment of Alcohol Associated Hepatitis

Prospective, single center, open label, randomized controlled trial to determine the feasibility of conducting a future study with respect to patient recruitment, digoxin administration and dose adjustment. The study intervention will be intravenous digoxin (renal-based dosing for maximum of 28 days) versus no digoxin in an open-label 1:1 randomized allocation …

  • 0 views
  • 02 Dec, 2021
  • 1 location
Comparison of Inflammatory Profiles and Regenerative Potential in Alcoholic Liver Disease

The main objective of this study is the comparison of the profile of the pro-inflammatory cytokines at the patients suffering from an alcoholic hepatitis to that of two groups witnesses

cancer
liver metastasis
cytokines
hepatitis
cirrhosis
  • 0 views
  • 27 Jan, 2021
  • 1 location