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Found 77 clinical trials
Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of QBW251 in Subjects With Bronchiectasis

clinical safety and efficacy related to improved mucociliary clearance with reduced bacterial colonization as potential drivers of airway obstruction, reduced airway inflammation, exacerbations and mucus

pulmonary function test
chest physiotherapy
cystic fibrosis
  • 22 Apr, 2022
  • 14 locations
Speeding the Weaning up: Aggressive Screening Criteria and Higher Minimal Ventilatory Settings.

Hypothesis In patients with less than 4 high risk factors for reintubation excluding body mass index >30 and hypercapnia during the spontaneous breathing trial (SBT) (low and intermediate risk for extubation failure), who receive preventive therapy with high flow nasal cannula (HFNC), the use of SBT with "HIGH minimal ventilator …

  • 03 May, 2021
  • 1 location
Prevention of Airway Obstruction Events

The standard for treatment for people suffering from obstructive sleep apnea (OSA) syndrome involves the use of Continuous, or Automatic Positive Airway Pressure (CPAP, APAP) machines, which work by delivering air via tubing and mask to a patient at pressures of up to 20cmH2O. This increased pressure is meant to …

  • 26 Apr, 2022
Flow Cytometry Analysis of Eosinophils in Severe Asthma Patients.

Asthma is a heterogeneous disease, characterized by reversible airflow obstruction, airway hyperresponsiveness, and airway inflammation, in which 40% of patients exhibit eosinophil-driven

  • 21 Aug, 2021
  • 1 location
Slow Expiratory Technique to Improve Alimentation in Children With Bronchiolitis (BRONCHIOL-EAT)

The purpose of this study is to determine wether a single chest physiotherapy session with slow expiratory technique (SET) improves infants with viral bronchiolitis quality of life (food intake and sleep) on the next 24 hours.

  • 13 Feb, 2022
  • 1 location
Hyperpolarized Xenon-129 MR Imaging of the Lung

Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine phenotypes similar to those of human COPD. Recently, "spiked" vape juice has been linked …

  • 26 Jan, 2021
  • 1 location
Transcranial Electrostimulation and Obstructive Sleep Apnea Surgery

Postoperative pain after major surgery for obstructive sleep apnea (OSA), such as palatopharyngoplasty (PPP) and maxillomandibular advancement (MMA) is moderate-to-severe, and may persist for weeks. Control of this pain may be difficult, because OSA patients are very sensitive to traditional opioid pain medications, and their side effects. Poorly controlled pain …

  • 27 May, 2021
  • 1 location
Incidence of Acute Laryngeal Injury Following Endotracheal Intubation

The purpose of this investigation is to delineate the incidence of acute and chronic laryngeal injury following intubation within our health system. In addition, this study seeks to identify risk factors for airway injury that may provide information to help reduce the incidence of injury or increase the speed of …

endotracheal intubation
  • 05 Nov, 2021
  • 1 location
Surgical Treatment of Tonsillar Abscess

The diagnosis and treatment of tonsillar abscess are very physician-dependent, as sufficient prospective medical literature is lacking to choose the most efficient regimen. The proposed study aims to assess the therapeutic efficacy of tonsillectomy compared to drainage under local anesthesia. This is a prospective, randomized clinical trial in adults in …

  • 15 May, 2021
  • 1 location
Effect of Coffee and Tea Consumption on Adolescent Weight Control

Introduction: The influence of tea or coffee supplementation on body weight in adolescents has never been tested. The aim of the present study was to investigate the effect of tea and coffee consumption on body weight and body fat in an obese adolescent population. Methods: Randomized clinical trial, parallel group …

  • 25 Mar, 2022