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Found 94 clinical trials
MoleGazer Development Feasibility Study

Melanoma (skin cancer) frequently develops from existing moles on the skin. Current practice relies on expert dermatologists being able to successfully identify new/changing moles in individuals with multiple moles. Total body photography (TBP-high-quality images of the entire skin) can track and monitor moles over time to detect melanoma. However, TBP …

cancer
skin cancer screening
  • 0 views
  • 30 Sep, 2021
  • 1 location
MGD019 DART® Protein in Unresectable/Metastatic Cancer

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics (PK) pharmacodynamics and preliminary antitumor activity of lorigerlimab. This Phase 1, open-label study will characterize safety, dose-limiting toxicities (DLTs), and maximum tolerated/administered dose (MTD/MAD) of MGD019. Dose escalation will occur in a 3+3+3 design in patients with …

solid tumour
ROS1
metastasis
BRAF
EGFR
  • 18 views
  • 13 May, 2022
  • 29 locations
Axitinib + Ipilimumab in Advanced Melanoma

The goal of this clinical research study is to find out if taking axitinib with ipilimumab is effective in treating advanced melanoma.

ipilimumab
hepatitis
advanced melanoma
mek inhibitor
human chorionic gonadotropin
  • 0 views
  • 02 Jul, 2022
  • 1 location
Tinostamustine and Nivolumab in Advanced Melanoma

This trial is a first-in-human drug combination with the first-in-class alkylating histone deacetylase inhibition (HDACi) fusion molecule Tinostamustine (EDO-S101) and the anti-PD-1 monoclonal antibody Nivolumab in patients with refractory, locally advanced or metastatic melanoma.

  • 0 views
  • 22 Jan, 2021
  • 2 locations
HL-085 in NRAS-mutated Advanced Melanoma

This was an open-label, single-arm, multi-center phase II clinical study, aimed at investigating the efficacy and safety of HL-085 capsule in the treatment of advanced melanoma patients with

NRAS
alopecia
advanced melanoma
  • 0 views
  • 23 Mar, 2022
  • 2 locations
Adoptive T Cell Immunotherapy for Advanced Melanoma Using Engineered Lymphocytes

initiated therapy for patients with advanced melanoma.

metastatic melanoma
interleukin-2
advanced melanoma
mek inhibitor
lymphocyte antigen
  • 19 views
  • 22 Jan, 2021
  • 1 location
Dendritic Cell Vaccination in Patients With Advanced Melanoma

The purpose of this study is to investigate a method of using dendritic cells (a kind of white blood cell) as a vaccine to stimulate your own immune system to react to your melanoma cells.

cyclophosphamide
vaccination
advanced melanoma
pembrolizumab
measurable disease
  • 15 views
  • 24 Mar, 2022
  • 1 location
Study on TIL for the Treatment of Advanced Melanoma

This study is to investigate the safety and efficacy of tumor infiltrating lymphocyte (TIL) therapy in patients with advanced melanoma. Autologous TILs are expanded from tumor resections or

  • 0 views
  • 06 Nov, 2021
  • 1 location
Nivolumab/Ipilimumab Plus Cabozantinib in Patients With Unresectable Advanced Melanoma

In this phase II advanced melanoma study, all patients will receive treatment with nivolumab/ipilimumab plus cabozantinib for a 12 week induction period followed by nivolumab plus cabozantinib

advanced melanoma
ipilimumab
nivolumab
measurable disease
  • 8 views
  • 11 May, 2022
  • 3 locations
MEK Inhibitor FCN-159 To Treat Advanced Melanoma With NRAS-aberrant (Ia) and NRAS-mutant (Ib)

Melanoma is one of the most common cutaneous cancers worldwide. Activating mutations in RAS oncogenes are found in a third of all human cancers and NRAS mutations are found in 15%-20% of melanomas. Acquisition of a functional mutation in NRAS results in activation of the Ras / Raf / MEK …

metastatic melanoma
NRAS
solid tumour
advanced melanoma
metastasis
  • 7 views
  • 05 Feb, 2022
  • 1 location