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Found 94 clinical trials
Biomarkers for the Activity of Immune Checkpoint Inhibitor Therapy in Patients With Advanced Melanoma

Screen and recruitment: patients will be screened based on their prior history and intention to initiate treatment with an immune checkpoint inhibitor. Study phase: Collection of baseline demographic data, prior disease history, nature of ICI therapy, outcome data of ICI therapy (treatment disposition, toxicity, tumor response and survival). Collection of …

advanced melanoma
metastasis
  • 24 views
  • 27 Jan, 2021
  • 2 locations
Peripheral T Cell Determinants of Response and Resistance to Pembrolizumab in Melanoma

This is a non-therapeutic study assessing peripheral T cell determinants of response and resistance to immunotherapy in patients with advanced melanoma.The hypothesis is that systemic T cells traffic into the tumor microenvironment (TME) can predict response and resistance to immunotherapy. These systemic tumor directed T cells can be defined by …

measurable disease
pembrolizumab
cancer
advanced melanoma
metastatic melanoma
  • 0 views
  • 24 Nov, 2021
  • 1 location
Predicting Response to Immunotherapy for Melanoma With Gut Microbiome and Metabolomics (PRIMM)

This study will investigate the effects of gut microbiome diversity (richness in terms of many bacterial species in the gut) on responses and side effects of immunotherapy in advanced melanoma

advanced melanoma
cancer
  • 7 views
  • 13 Feb, 2022
  • 5 locations
Serial Tumour Biopsies and Blood Biomarkers in Melanoma

with locally advanced and metastatic malignant melanoma. The study will be open to NHS patients aged 16 and over, who have been diagnosed with advanced melanoma, and who will be receiving

advanced melanoma
metastatic melanoma
cancer
cancer treatment
  • 0 views
  • 25 Jan, 2021
  • 1 location