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Found 319 clinical trials
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors (SPARTA)

The primary Phase 1 purpose of this study was to assess overall safety, tolerability and recommended Phase 2 dose (RP2D) of APL-101. The Phase 2 portion will assess efficacy of the dose determined in Phase 1 in individuals with Non-Small Cell Lung Cancer with c-Met EXON 14 Skip Mutations; individuals …

growth factor
lung carcinoma
epidermal growth factor receptor
cancer
epidermal growth factor
  • 326 views
  • 04 Oct, 2022
  • 85 locations
A Study to Examine the Clinical Value of Comprehensive Genomic Profiling Performed by Belgian NGS Laboratories: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Centre

highest quality standards. This 2-year study involves the consortium of 9 cooperating Belgian NGS laboratories and will enroll 936 metastatic or locally advanced cancer patients coming from 13

cancer
breast cancer
EGFR
  • 0 views
  • 05 Oct, 2021
  • 12 locations
A Study to Examine the Value of Broad Agnostic Next Generation Sequencing (NGS) Panel Testing Versus Reimbursed Organ-directed NGS: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Center

very limited current reimbursed conditions. The investigators estimate that up to 20% of advanced cancer patients could get access to genotype-based treatment that are not covered by the organ

cancer
breast cancer
EGFR
  • 0 views
  • 05 Jun, 2021
  • 12 locations
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).

vulvar carcinoma
cancer
mk-3475
small intestine
pembrolizumab
  • 15 views
  • 04 Oct, 2022
  • 24 locations
A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of KY1044 as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies

A Phase 1/2, open label, multi-center study to evaluate the safety, efficacy and tolerability of KY1044 as single agent and in combination with anti-PD-L1 (atezolizumab) in adult patients with selected advanced malignancies, who are ineligible for or there are no available therapies known to confer a clinical benefit for their …

pd-l1
lung carcinoma
carcinoma
cancer
squamous cell carcinoma of head and neck
  • 101 views
  • 18 Oct, 2022
  • 10 locations
Molecular Breast Imaging and Digital Breast Tomosynthesis in Screening Patients With Dense Breast Tissue

This study compares molecular breast imaging (MBI) and digital breast tomosynthesis (DBT) in screening patients with dense breast tissue. Breast imaging may help doctors find breast cancer sooner, when it may be easier to treat. Molecular breast imaging (MBI) uses an injection of a small amount of radioactive material that …

breast cancer
mammogram
Accepts healthy volunteers
cancer
breast imaging reporting and data system
  • 17 views
  • 17 Jun, 2022
  • 2 locations
Validation of a microRNA-based Fecal (miRFec) Test for Colorectal Cancer Screening (miRFec)

The present study aims to compare effectiveness and cost-effectiveness of the miRFec test with respect to fecal immunochemical test (FIT) for the detection of advanced colorectal neoplasm among individuals participating in colorectal cancer (CRC) screening.

  • 0 views
  • 15 May, 2022
  • 1 location
Integrated Cervical Cancer Screening in Mayuge District Uganda (ASPIRE Mayuge) (ASPIRE)

The purpose of this pragmatic cluster randomized control trial is to test the effectiveness of cervical cancer screening follow-up completion using two implementation approaches for self-collected HPV testing in a rural, low-resource setting: 1) community health workers recruiting women door-to-door and 2) community health workers recruiting women at community health …

cancer screening
cervical cancer screening
human papilloma virus vaccine
Accepts healthy volunteers
cancer
  • 0 views
  • 05 Mar, 2022
  • 1 location
PSMA PET/CT Guided Intensification of Therapy in Patients at Risk of Advanced Prostate Cancer

Through the conduct of a Phase III randomized controlled trial, investigators plan to: 1) determine if PSMA PET/CT guided intensification of radiotherapy or surgery improves cancer outcomes compared to conventional imaging-guided therapy in patients at risk of advanced disease, 2) evaluate its impact on toxicity and quality of life, and …

  • 0 views
  • 06 Dec, 2021
  • 11 locations
Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly (ACP-PEACE)

In this research study, the investigators are working to help oncologists better serve patients by delivering more patient-centered, goal-concordant care that may improve health care delivery. It is expected that about 30,000 people will take part in this research study, 29,550 of these patients, the vast majority, will be included …

  • 0 views
  • 04 Oct, 2022
  • 3 locations