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Found 319 clinical trials
Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer (NORAD01)

This study is a non-inferiority phase III randomised trial comparing preoperative chemotherapy alone (modified FOLFIRINOX) to chemotherapy followed by chemoradiotherapy in patients with primary resectable locally advanced rectal cancer. The primary endpoint of the study is 3-year progression free survival. Expected 3 year PFS rate in the preoperative chemotherapy followed …

oxaliplatin
chemoradiotherapy
irinotecan
carcinoma
capecitabine
  • 0 views
  • 01 Jul, 2022
  • 3 locations
KAZ954 Alone and With PDR001, NZV930 and NIR178 in Advanced Solid Tumors

The purpose of this trial is to explore the clinical utility of several therapies in patients with advanced cancer. This is a multi-center, open-label Phase I/Ib study. The study consists

cancer
advanced cancer
  • 7 views
  • 13 Jun, 2022
  • 12 locations
A Phase Ia/Ib, Open Label, Multicenter, Dose-escalation Study of BI 907828 in Patients With Advanced or Metastatic Solid Tumors

This study is open to adults with different types of advanced cancer (solid tumors). The purpose of this study is to find out the most suitable dose of BI 907828 the participants can tolerate

measurable disease
advanced cancer
TP53
solid neoplasm
primary cancer
  • 57 views
  • 28 Oct, 2022
  • 19 locations
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer (TAPUR)

The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug

hodgkin's disease
advanced cancer
vasectomy
lymphoma
multiple myeloma
  • 200 views
  • 07 Oct, 2022
  • 126 locations
An Open Label, Phase I Dose Escalation Trial, With Dose Confirmation and Expansion, of BI 1810631 as Monotherapy in Patients With Advanced or Metastatic Solid Tumors With HER2 Aberrations

The study has 2 parts. The first part is open to adults with different types of advanced cancer (solid tumours with changes in the HER2 gene) for whom previous treatment was not successful. The

BRAF
lung carcinoma
growth factor
glomerular filtration rate
epidermal growth factor receptor
  • 0 views
  • 25 Oct, 2022
  • 7 locations
Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.

ki-ras
solid neoplasm
pembrolizumab
treatment regimen
KRAS
  • 7 views
  • 11 Mar, 2022
  • 78 locations
RNASARC - Molecular Screening Program of Soft Tissue Sarcomas With Complex Genomic Profile to Detect NTRK1/2/3, ROS1 or ALK Gene Fusions. (RNASARC)

This trial is a multicenter, prospective cohort study aiming to describe molecular profiles of soft tissue sarcoma (STS) with complex genomic profiles in particular to assess the incidence of NTRK1/2/3, ROS1 or ALK gene fusions to direct such patients through an ongoing clinical trial with entrectinib when appropriate. An exploratory …

eosin
angiosarcoma
liposarcoma
soft tissue sarcoma
undifferentiated pleomorphic sarcoma
  • 40 views
  • 27 Feb, 2022
  • 10 locations
A Phase Ia/Ib, Open Label, Dose-escalation Study of the Combination of BI 907828 With BI 754091 (Ezabenlimab) and BI 754111 and the Combination of BI 907828 With BI 754091(Ezabenlimab) Followed by Expansion Cohorts, in Patients With Advanced Solid Tumors

This study has 2 parts. The first part is open to adults with different types of advanced cancer (solid tumors). The second part is open to people with specific types of soft tissue sarcoma

BRAF
adenocarcinoma
liver metastasis
advanced cancer
EGFR
  • 6 views
  • 20 Oct, 2022
  • 12 locations
A Dutch National Study on Behalf of the CPCT to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to Determine the Potential Efficacy in Treatment of Advanced Cancers With a Known Molecular Profile (DRUP)

with advanced cancer with a potentially actionable variant as revealed by a genomic or protein expression test. The study also aims to simplify patient access to approved targeted therapies that are

ovarian cancer
advanced malignant solid tumor
advanced cancer
erlotinib
lymphoma
  • 266 views
  • 10 Oct, 2022
  • 35 locations
PREACT Study: Locally Advanced Gastric Cancer, Chemoradiotherapy vs. Chemotherapy Followed by D2 Surgery and Adjuvant Chemotherapy (PREACT)

Although the incidence of gastric cancer has been substantially declining for several decades, it is still the sixth most common cancer and the fourth most frequent cause of cancer death worldwide. Surgery is still the only curative option for gastric cancer. However, most patients are unable to undergo surgery because …

serum bilirubin
oxaliplatin
gastrectomy
gastric resection
pre-operative chemotherapy
  • 22 views
  • 24 Feb, 2022
  • 1 location