Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 162 clinical trials
Palbociclib for HR Positive / HER2-negative Isolated Locoregional Recurrence of Breast Cancer

POLAR is a phase III clinical trial, which will test the safety and efficacy of an investigational combination of drugs to learn whether the combination of drugs works for a specific cancer. Palbociclib (Ibrance) is the name of the investigational agent, which is assessed together with standard anti-hormone therapy in …

endocrine therapy
exemestane
cancer
tamoxifen
hormone therapy
  • 0 views
  • 21 Feb, 2021
  • 66 locations
MEtronomic TrEatment Option in Advanced bReast cAncer

This is a multi-center, randomized phase II trial that will randomise women with ER-positive, HER2-negative (Human Epidermal Growth factor Receptor 2-negative) metastatic or locally relapsed breast cancer in a ratio of 1:1 to receive a metronomic regimen of vinorelbine plus cyclophosphamide and capecitabine, or the conventional paclitaxel monotherapy.

taxane
advanced breast cancer
vinorelbine
metastasis
stage iv breast cancer
  • 58 views
  • 24 Jan, 2021
  • 24 locations
HR+/HER2- Advanced Breast Cancer and Endocrine Resistance

This is a randomized, 2-arm, open-label, multicenter, international phase II trial. A total of 196 patients will be included. The study will include patients with metastatic Hormone Receptor positive / Human Epidermal Growth Factor Receptor (HER2) negative breast cancer with progressive disease after endocrine treatment. Patients will be randomized (1:1) …

kidney function tests
taxane
measurable disease
her2-negative breast cancer
metastasis
  • 49 views
  • 25 Jan, 2021
  • 13 locations
Gut Microbiome & Gastrointestinal Toxicities as Determinants of Response to Neoadjuvant Chemo for Advanced Breast Cancer

The purpose of this research is to test whether bacteria that normally live in the intestines play a role in fighting cancer. It is believed that the development and behavior of these immune cells may be influenced by bacteria and other microorganisms living in the gut. In turn, the activities …

KIT
cancer treatment
advanced breast cancer
invasive breast cancer
breast surgery
  • 0 views
  • 25 Jan, 2021
  • 1 location
Pyrotinib Combined With Capecitabine Metronomic Therapy in HER2-postitive Advanced Breast Cancer

breast cancer, For patients who have progressed or relapsed after trastuzumab treatment, There are still many issues to explore on the choice of program of retargeted therapy. In HER2-positive advanced

measurable disease
advanced breast cancer
trastuzumab
metastasis
HER2
  • 0 views
  • 23 Jan, 2021
  • 1 location
Phase II Clinical Study of Pyrotinib Combined With Etoposide to Treat HER2-positive Advanced Breast Cancer

The purpose of this study is to assess the efficacy and safety of Pyrotinib Combined With Etoposide to Treat HER2-positive Advanced Breast Cancer

measurable disease
advanced breast cancer
trastuzumab
lapatinib
metastasis
  • 6 views
  • 23 Jan, 2021
  • 1 location
FACILE: FeAsibility of First-line riboCIclib in oLdEr Patients With Advanced Breast Cancer

, with hormone receptor positive/HER2 negative advanced breast cancer

cish
progesterone receptor
advanced breast cancer
aromatase inhibitor
chromogenic in situ hybridization
  • 0 views
  • 27 Jan, 2021
  • 1 location
Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer

A Phase 1 Dose Escalation and Expansion Study of AZD9833 Alone or in Combination in Women with ER Positive, HER2 Negative Advanced Breast Cancer (SERENA-1)

  • 84 views
  • 26 Feb, 2021
  • 17 locations
TALAVE: Induction Talazoparib Followed by Combination of Talazoparib and Avelumab in Advanced Breast Cancer

This is a multi-institutional pilot trial for patients with advanced breast cancer. The trial is designed to assess the safety and tolerability of induction talazoparib followed by combination

measurable disease
advanced breast cancer
  • 32 views
  • 05 Feb, 2021
  • 3 locations
Neoadjuvant Toremifene With Melatonin or Metformin in Locally Advanced Breast Cancer

This study evaluates the addition melatonin and metformin to toremifene in the treatment of locally advanced breast cancer. Third of patients will receive toremifene, other third will receive

locally advanced breast cancer
advanced breast cancer
breast cancer staging
  • 1 views
  • 23 Jan, 2021
  • 1 location