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Found 161 clinical trials
A Study Comparing a Dose-Titration Regimen of Fulvestrant With the Approved Dosing Regimen in Postmenopausal Patients With Hormone-Responsive Advanced Breast Cancer (ABC)

In post-menopausal metastatic hormone-responsive breast cancer women. This study is a two arm randomized trial to evaluate the effectiveness of dose-titration regimen of fulvestrant compared with the approved dosing regimen. Patients will be randomized to one of the following treatment arms: Arm A: Fulvestrant 500 mg days 0, 14, 28, …

estradiol
stage iv breast cancer
gonadotropin releasing hormone
measurable disease
advanced breast cancer
  • 0 views
  • 07 Nov, 2020
  • 1 location
[18F]Fluorothymidine (FLT) PET/CT Imaging In Rb+ Metastatic Breast Cancer Patients Undergoing LEE011 And Weekly Paclitaxel Therapy

Paclitaxel in Patients with Rb+ Advanced Breast Cancer" may be candidates for this imaging study. Patients may participate in this study if they are at least 18 years of age, most participants will be

HER2
advanced breast cancer
paclitaxel
erbb2
  • 5 views
  • 08 Nov, 2020
  • 1 location
Glucagon Receptor Inhibition to Enable Breast Cancer Patients to Benefit From PI3K Inhibitor Therapy (REMD-477)

hypotheses that REMD-477 is safe and tolerable in patients with severe hyperglycemia on apelisib and prevent hyperglycemia associated with alpelisib in patients with advanced breast cancer who discontinue

  • 0 views
  • 26 Jan, 2021
  • 1 location
Targeted Biopsy of Carbon Nanoparticles Labelled Axillary Node for cN+ Breast Cancer

To explore the feasibility of target biopsy of carbon nanoparticles labelled lymph node after neoadjuvant systemic therapy for cN+ breast cancer, and evaluate whether it can accurately predict axillary lymph node status after neoadjuvant systemic therapy.

  • 0 views
  • 30 Jan, 2021
  • 1 location
Xeloda Plus Paclitaxel in Gastric Cancer With Liver Metastasis

To investigate the efficacy of capecitabine combined with paclitaxel as neoadjuvant chemotherapy for gastric cancer with liver metastasis only

capecitabine
metastasis
xeloda
cancer chemotherapy
paclitaxel
  • 16 views
  • 08 Nov, 2020
  • 1 location
Ribociclib and Letrozole Treatment in Ovarian Cancer

The study evaluates the response to treatment with Ribociclib and Letrozole in patients with low grade serous cancer of the ovary, fallopian tube or peritoneum.

  • 26 views
  • 03 Feb, 2021
  • 26 locations
Functional Precision Oncology for Metastatic Breast Cancer

This is a pilot study to assess the feasibility of comprehensive genomic characterization and drug screening in metastatic breast cancer. The trial will seek to provide personalized genomic and drug sensitivity information to eligible patients with metastatic breast cancer prior to disease progression on standard treatment. The trial will also …

  • 0 views
  • 24 Feb, 2021
  • 1 location
Evaluation of Lasofoxifene Versus Fulvestrant in Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

This is an open label, randomized, multicenter study evaluating the activity of lasofoxifene relative to fulvestrant for the treatment of pre- and postmenopausal women with locally advanced or metastatic ER+/HER2- breast cancer with an acquired ESR1 mutation and who have disease progression on an aromatase inhibitor (AI) in combination with …

  • 38 views
  • 27 Jan, 2021
  • 52 locations
PALbociclib Rechallenge in horMone Receptor-posItive/HER2- Negative Advanced Breast Cancer (PALMIRA)

Hormone Receptor (HR)-positive/Human Epidermal Growth Factor Receptor 2 (HER2)-negative advanced breast cancer (ABC)

estradiol
letrozole
liquid biopsy
mammogram
aromatase inhibitor
  • 63 views
  • 27 Jan, 2021
  • 67 locations
Amcenestrant (SAR439859) Plus Palbociclib as First Line Therapy for Patients With ER (+) HER2(-) Advanced Breast Cancer

palbociclib in participants with ER+, HER2- advanced breast cancer who have not received any prior systemic anticancer therapies for advanced disease. Secondary Objective: To compare the

letrozole
her2/neu-negative breast cancer
measurable disease
advanced breast cancer
palbociclib
  • 0 views
  • 04 Mar, 2021
  • 79 locations