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Found 18 clinical trials
Study of a Pembrolizumab-based Organ Preservation Strategy for Locally Advanced Larynx Cancers (SMART KEY)

immunotherapy in patients with locally advanced squamous cell carcinoma of the larynx who are candidates for organ preservation.

  • 0 views
  • 07 Mar, 2022
Rigosertib in Patients With Recessive Dystrophic Epidermolysis Bullosa Associated SCC

This pilot trial studies how rigsertib sodium works in treating patients with Recessive Dystrophic Epidermolysis bullosa (RDEB) with locally advanced Squamous Cell Carcinoma (SCC). Rigosertib

  • 0 views
  • 08 Sep, 2021
  • 1 location
Perioperative Toripalimab (JS001) Combined With Neoadjuvant Chemotherapy in Patients With Resectable Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma

This is a randomized, placebo-controlled, multi-center, double-blinded, Phase III study to determine the efficacy and safety of patients with locally advanced squamous cell carcinoma of the

  • 0 views
  • 10 May, 2022
  • 42 locations
Dual Inhibition of EGFR With Afatinib and Cetuximab in the Treatment of Advanced Squamous Cell Cancers of the Head and Neck

This is a single arm Phase II study for patients with recurrent or metastatic squamous cell carcinoma of the head and neck, who are previously treated with a platinum based regimen or with an immune checkpoint inhibitor. The primary objective is to evaluate the efficacy of the combination of cetuximab …

  • 42 views
  • 24 Mar, 2022
  • 1 location
A Study of Debio 1143 (Xevinapant) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)

The primary objective of the study is to demonstrate superior efficacy of Debio 1143 vs placebo when added to chemoradiotherapy (CRT) in locally advanced squamous cell carcinoma of the head and

  • 4 views
  • 28 Apr, 2022
  • 134 locations
Chemoradiotherapy Followed by Planned Surgery or by Surveillance and Surgery Only When Needed for Oesophageal Cancer (NEEDS)

squamous cell carcinoma (SCC) of the esophagus, with the aim to provide generalisable guidance for future clinical practice.

chemoradiotherapy
paclitaxel
folfox regimen
cancer
carboplatin
  • 0 views
  • 23 Apr, 2022
  • 8 locations
Palbociclib With Cetuximab and IMRT for Locally Advanced Squamous Cell Carcinoma

Cyclin D kinase 4 (CDK4) is a key regulator of the G1-S transition in the cell cycle. Alterations in CDK4-cyclin D-retinoblastoma (Rb) pathway may lead to carcinogenesis in many cancers. Several mechanisms have been described: (i) Amplification or overexpression of cyclin D1, (ii) Amplification of CDK4, (iii) Activating mutation of …

intensity-modulated radiation therapy
head and neck carcinoma
dental caries
squamous cell carcinoma of head and neck
squamous cell carcinoma of the oral cavity
  • 82 views
  • 31 Jan, 2022
  • 1 location
Treatment of Locally Advanced VULvar CArcinoma in a Neoadjuvant Setting With Carboplatin and Paclitaxel Chemotherapy (VULCANize)

Vulvar cancer is a rare malignancy. Surgery is the treatment of choice, but frequently causes invalidating and chronic postoperative morbidity, especially in patients with high stage disease. Theoretically, downstaging with neoadjuvant chemotherapy could shrink the tumour, making surgical treatment less extensive thereby diminishing the chance for morbidity.

  • 0 views
  • 24 Jan, 2021
  • 1 location
A Prospective Randomized Trial of Capecitabine Treatment in Patients With HNSCC

This prospective randomized controlled clinical Trial will be performed in patients with locally advanced squamous cell carcinoma of the head and neck. The objectives of the trial are to compare

head and neck carcinoma
squamous cell carcinoma of head and neck
locally advanced squamous cell carcinoma
platelet count
immunomodulator
  • 7 views
  • 14 Feb, 2022
  • 1 location
First-in-human Study of DRP-104 (Sirpiglenastat) as Single Agent and in Combination With Atezolizumab in Patients With Advanced Solid Tumors.

advanced squamous cell carcinoma of the head and neck (SCCHN).

caries
advanced squamous cell carcinoma
atezolizumab
cancer treatment
chemotherapy regimen
  • 0 views
  • 28 Jun, 2021
  • 9 locations