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Found 93 clinical trials
A Study of IMO-2125 in Combination With Ipilimumab Versus Ipilimumab Alone in Subjects With Anti-PD-1 Refractory Melanoma (ILLUMINATE-301)

A Phase 3 comparison of ipilimumab with and without IMO-2125 in advanced melanoma

  • 185 views
  • 27 Feb, 2019
  • 12 locations
SentoClone Compared to Reference Treatment in Advanced Malignant Melanoma

The purpose of this study is to elucidate whether SentoClone® gives improved treatment responses in patients with advanced malignant melanoma in comparison to established reference

metastasis
dacarbazine
measurable disease
temozolomide
  • 14 views
  • 08 Nov, 2020
  • 5 locations
Nab-PCE vs PC for MM After Failure of Anti-PD-1

This is a randomized controlled clinical trial of nab-paclitaxel + carboplatin Endostatin for advanced melanoma after failure of PD-1 therapy. The aim was to evaluate the efficacy

brain metastases
metastasis
renal function
measurable disease
  • 0 views
  • 22 Jan, 2021
  • 1 location
Combination Therapy With GEN0101 and Pembrolizmub in Advanced Melanoma Patients PIb/PII

advanced melanoma.

  • 0 views
  • 22 Jan, 2021
  • 7 locations
Adoptive Tumor-infiltrating Lymphocyte Transfer With Nivolumab for Melanoma

This study is to investigate safety and feasibility of a combination therapy of a tumor infiltrating lymphocytes (TIL) transfer with anti-programmed cell death protein (PD)-1 therapy in patients with metastatic melanoma that failed immunotherapy.Tumor-infiltrating lymphocytes will be expanded from resected melanoma samples from the patient and expanded TILs will be …

metastasis
gilbert's syndrome
cyclophosphamide
liver metastasis
measurable disease
  • 0 views
  • 25 Jan, 2021
  • 1 location
A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

The purpose of this study is to evaluate the effectiveness and safety of the combination of Pembrolizumab (KEYTRUDA) and the investigational drug, Metformin.

international normalized ratio
metastasis
flow cytometry
brain metastases
nivolumab
  • 0 views
  • 03 Dec, 2020
  • 1 location
Phase 1B Study Evaluating Alternative Routes of Administration of CMP-001 in Combination With Pembrolizumab in Participants With Advanced Melanoma

CMP-001-002 is a Phase 1b study of CMP-001 administered to participants with advanced melanoma who are either receiving pembrolizumab, or who have previously received an anti-programmed cell

ocular melanoma
advanced melanoma
pembrolizumab
platelet count
neutrophil count
  • 52 views
  • 17 Nov, 2019
  • 4 locations
Cabozantinib and Pembrolizumab for Advanced Metastatic Melanoma

The study aims to evaluate the safety and preliminary efficacy of the combination of cabozantinib and pembrolizumab in advanced melanoma

  • 0 views
  • 25 Jan, 2021
  • 1 location
A Study of IBI310 in Treatment of Patients With Advanced Solid Tumors.

combination of sintilimab in patients with advanced solid tumors(Ia) and advanced melanoma(Ib).

  • 5 views
  • 22 Jan, 2021
Efficacy and Safety Study of Niraparib in Melanoma With Genetic Homologous Recombination (HR) Mutation

This open-label phase II trial studies how well niraparib works in treating patients with advanced, metastatic melanoma with the homologous recombination (HR) pathway gene mutation / alteration. Niraparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The trial is designed to …

  • 14 views
  • 24 Jan, 2021
  • 1 location