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Found 101 clinical trials
Study of Quavonlimab (MK-1308) in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)

This study will assess the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of escalating doses of quavonlimab when used in combination with pembrolizumab in participants with advanced solid tumors.

  • 774 views
  • 22 Sep, 2021
  • 56 locations
SentoClone Compared to Reference Treatment in Advanced Malignant Melanoma

The purpose of this study is to elucidate whether SentoClone® gives improved treatment responses in patients with advanced malignant melanoma in comparison to established reference

measurable disease
temozolomide
dacarbazine
metastasis
  • 14 views
  • 08 Nov, 2020
  • 5 locations
FLX475 in Combination With Ipilimumab in Advanced Melanoma

This clinical trial is a Phase 2, open-label study to determine the anti-tumor activity of FLX475 in combination with ipilimumab in subjects with advanced melanoma previously treated with an

  • 0 views
  • 22 Sep, 2021
  • 4 locations
A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

The purpose of this study is to evaluate the effectiveness and safety of the combination of Pembrolizumab (KEYTRUDA) and the investigational drug, Metformin.

measurable disease
aptt
investigational drug
flow cytometry
international normalized ratio
  • 0 views
  • 27 Jan, 2021
  • 1 location
Nab-PCE vs PC for MM After Failure of Anti-PD-1

This is a randomized controlled clinical trial of nab-paclitaxel + carboplatin Endostatin for advanced melanoma after failure of PD-1 therapy. The aim was to evaluate the efficacy

measurable disease
renal function
metastasis
brain metastases
  • 0 views
  • 22 Jan, 2021
  • 1 location
Adoptive Tumor-infiltrating Lymphocyte Transfer With Nivolumab for Melanoma

This study is to investigate safety and feasibility of a combination therapy of a tumor infiltrating lymphocytes (TIL) transfer with anti-programmed cell death protein (PD)-1 therapy in patients with metastatic melanoma that failed immunotherapy.Tumor-infiltrating lymphocytes will be expanded from resected melanoma samples from the patient and expanded TILs will be …

hepatitis b antigen
measurable disease
interleukin
cyclophosphamide
metastatic melanoma
  • 0 views
  • 14 Aug, 2021
  • 1 location
  • 0 views
  • 22 Jan, 2021
  • 7 locations
A Study to Assess LBL-007 in Combination With Toripalimab in Subjects With Advanced Melanoma

This is a multi-center ,open-label, single-arm,dose-escalation,and extended phase I of LBL-007 in combination with Toripalimab. The study is designed to assess the safety, tolerability and efficacy of LBL-007 in combination with Toripalimab in the treatment of unresectable or metastatic melanoma(including Cutaneous melanoma, Acral melanoma, Mucosal melanoma, and melanoma of unknown …

  • 0 views
  • 07 Jun, 2021
  • 3 locations
Safety and Efficacy of Selinexor in Combination With Pembrolizumab in Recurrent Advanced Melanoma

Approximately 40 participants with locally advanced or metastatic melanoma will be enrolled in 20 sites in the United States into 1 of the following 2 arms: Primary resistance to initial checkpoint inhibitor (CPI) therapy in Arm A and Acquired resistance to initial CPI therapy in Arm B. Participants who have …

  • 0 views
  • 19 Sep, 2021
  • 8 locations
Cabozantinib and Pembrolizumab for Advanced Metastatic Melanoma

The study aims to evaluate the safety and preliminary efficacy of the combination of cabozantinib and pembrolizumab in advanced melanoma

  • 0 views
  • 22 Sep, 2021
  • 1 location