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Found 284 clinical trials
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A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor Malignancies Harboring Activating FGFR Mutations or Translocations (FIGHT-207)

The purpose of this study is to evaluate the efficacy and safety of pemigatinib in participants with previously treated locally advanced/metastatic or surgically unresectable solid tumor malignancies harboring activating FGFR mutations or translocations.  

cancer
FGFR3
measurable disease
solid tumor
malignancies
  • 46 views
  • 25 Aug, 2021
  • 57 locations
featured
A Phase 1/2 Trial of MRTX849 in Combination with TNO155 in Patients with Advanced Solid Tumors with KRAS G12C Mutation

Characterize the safety and tolerability, and evaluate Pharmacokinetics of MRTX849 in combination with TNO155 in patients with advanced solid tumor malignancies with KRAS G12C mutation.

solid tumors
advanced solid tumor
solid tumor
malignant solid tumor
  • 114 views
  • 19 Feb, 2021
  • 10 locations
  • 2 views
  • 26 Jan, 2021
  • 11 locations
A Phase I Study of AL8326 in Advanced Solid Tumor

Main purpose Objective to study the tolerance and safety of single and multiple administration of repeated 28-day cycles of AL8326 in patients with advanced solid tumor, observe the dose

  • 0 views
  • 24 May, 2021
  • 2 locations
A Study to Assess the Safety Tolerability and Pharmacokinetics of ABSK-011 in Patients With Advanced Solid Tumor

This is an open-label phase 1 study with an escalation part and an expansion part.

  • 0 views
  • 02 Jun, 2021
  • 1 location
A Study to Evaluate the Tolerance Efficacy and Pharmacokinetics of TQB3454 Tablets

This is a open-label, multicenter, phase I study to evaluate tolerance and pharmacokinetics of TQB3454 tablets in subjects with advanced solid tumor or hematologic tumor.

  • 0 views
  • 25 Jan, 2021
  • 1 location
A Phase I Study of TQB728 Tablets on Tolerance and Pharmacokinetics

This is a open-label, phase I study to evaluate tolerance and pharmacokinetics of TQB3728 tablets in subjects with advanced solid tumor or hematologic tumor.

  • 0 views
  • 27 Jan, 2021
  • 1 location
A Phase 1 Study With ABBV-CLS-484 in Subjects With Locally Advanced or Metastatic Tumors

The study will assess the safety, PK, PD, and preliminary efficacy of ABBV-CLS-484 as monotherapy and in combination with a PD-1 targeting agent. The trial aims to establish a safe, tolerable, and efficacious dose of ABBV-CLS-484 as monotherapy and in combination. The study will be conducted in three parts. Part …

  • 0 views
  • 19 Jun, 2021
  • 5 locations
Double/Triple Combinations of AN2025 AN0025 and Atezolizumab in Advanced Solid Tumors

This is an open-label, multicenter, Phase 1a study to evaluate the safety, tolerability, PK and preliminary efficacy of AN2025 and AN0025 in double or triple combination treatments with Atezolizumab in patients with locally advanced/metastatic tumors.

  • 0 views
  • 02 Sep, 2021
  • 4 locations
  • 0 views
  • 23 Jan, 2021
  • 1 location