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Found 47 clinical trials
Study of JS004 Combined With Toripalimab for Advanced Lung Cancer

This is an open-label phase I/II study to evaluate the safety, tolerability, pharmacokinetics and initial efficacy of JS004 injection combined with toripalimab in patients with advanced lung

  • 0 views
  • 17 Sep, 2021
  • 2 locations
Reqorsa (Quaratusugene Ozeplasmid) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib (Acclaim-1)

The purpose of this randomized study is to determine the safety and efficacy of Reqorsa (quaratusugene ozeplasmid, formerly known as GPX-001) added to osimertinib in NSCLC patients with activating EGFR mutations who have progressed while on treatment with osimertinib. Reqorsa consists of non-viral lipid nanoparticles that encapsulate a DNA plasmid …

cancer chemotherapy
advanced lung cancer
EGFR
tyrosine
lung carcinoma
  • 0 views
  • 01 May, 2022
  • 4 locations
  • 0 views
  • 29 Sep, 2021
  • 7 locations
Gefitinib in Combination With Anlotinib or Placebo in Previously Untreated EGFR-mutant NSCLC (FL-ALTER)

endothelial cells and reduce tumor microvascular density by targeting VEGFRs, FGFRs, PDGFRs. It has been proved to be safe and effective in advanced lung cancer after second-line standard chemotherapy failure

cancer chemotherapy
measurable disease
advanced lung cancer
targeted therapy
EGFR
  • 1 views
  • 17 Feb, 2022
Understanding and Overcoming the Early Adaptive Resistance to EGFR Tyrosine-kinase Inhibitors in Lung Cancer Patients (LUNG-RESIST)

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) are effective therapies for advanced lung cancer patients bearing EGFR-activating mutations, but are not curative due to

  • 0 views
  • 23 May, 2022
  • 1 location
Stepped Palliative Care Versus Early Integrated Palliative Care in Patients With Advanced Lung Cancer (STEP PC)

This research study is evaluating ways to provide palliative care to patients who have recently been diagnosed with lung cancer

cancer
lung cancer
advanced lung cancer
primary malignant neoplasm
lung carcinoma
  • 8 views
  • 03 Mar, 2022
  • 3 locations
An Investigational Immuno-therapy Trial of Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum-doublet Chemotherapy, Compared to Platinum Doublet Chemotherapy in Patients With Stage IV Non-Small Cell Lung Cancer (NSCLC) (CheckMate 227)

compared with chemotherapy in patients with advanced lung cancer.

stage iv non-small cell lung cancer
measurable disease
advanced lung cancer
cancer chemotherapy
nivolumab
  • 0 views
  • 25 Jan, 2022
  • 15 locations
Early Integrated Telehealth Versus In-Person Palliative Care for Patients With Lung Cancer (REACH PC)

This research study is evaluating ways to provide palliative care to patients who have recently been diagnosed with lung cancer and their families.

cancer
lung cancer
primary malignant neoplasm
lung carcinoma
  • 219 views
  • 07 Apr, 2022
  • 19 locations
Advanced Lung Tumor Treated by Osimertinib Plus Anlotinib

This is a prospective, single arm, phase Ib/IIa study. Up to 25 patients will be enrolled into the study (Part A: 2-18; Part B: 7-19). The study has been designed to allow an investigation of the optimal combination dose and schedule whilst of Osimertinib plus Anlotinib in patients with EGFRm+, …

  • 2 views
  • 07 Mar, 2021
  • 1 location
Microbiota Transplant in Advanced Lung Cancer Treated With Immunotherapy

The gut microbiota can modulate the effectiveness of cancer therapies, especially immunotherapy. Manipulating the microbial populations in patients with advanced lung cancer through fecal

cancer
total bilirubin
lung cancer
neutrophil count
absolute neutrophil count
  • 0 views
  • 03 Dec, 2021
  • 1 location